Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
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Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
14281006 | 206891 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 440 | 8 | 2 | 7 | 3.3 | COC(=O)CN(C(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL90804 | 206891 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 440 | 8 | 2 | 7 | 3.3 | COC(=O)CN(C(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
14281026 | 167971 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 410 | 7 | 2 | 5 | 4.5 | CN(C(=O)CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCCC1 | 10.1021/jm00092a019 | |
CHEMBL431799 | 167971 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 410 | 7 | 2 | 5 | 4.5 | CN(C(=O)CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCCC1 | 10.1021/jm00092a019 | |
14281025 | 206785 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 396 | 7 | 2 | 5 | 4.1 | CN(C(=O)CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL90237 | 206785 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 396 | 7 | 2 | 5 | 4.1 | CN(C(=O)CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
1711 | 77 | 15 | None | 1 | 7 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | |
5310983 | 77 | 15 | None | 1 | 7 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | |
CHEMBL336208 | 77 | 15 | None | 1 | 7 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | |
3352 | 2371 | 28 | None | -4 | 4 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human P2Y12 receptorAgonist activity at human P2Y12 receptor |
ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/jm900945d | |
5280879 | 2371 | 28 | None | -4 | 4 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human P2Y12 receptorAgonist activity at human P2Y12 receptor |
ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/jm900945d | |
5863 | 2371 | 28 | None | -4 | 4 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human P2Y12 receptorAgonist activity at human P2Y12 receptor |
ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/jm900945d | |
CHEMBL509456 | 2371 | 28 | None | -4 | 4 | Human | 8.9 | pEC50 | = | 8.9 | Functional | Agonist activity at human P2Y12 receptorAgonist activity at human P2Y12 receptor |
ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/jm900945d | |
1756 | 463 | 10 | None | 38 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | |
5310954 | 463 | 10 | None | 38 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | |
CHEMBL336292 | 463 | 10 | None | 38 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | |
5492386 | 206486 | 4 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 397 | 7 | 2 | 6 | 3.4 | O=S(=O)(CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)c1ccccc1 | 10.1021/jm00092a019 | |
CHEMBL88245 | 206486 | 4 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 397 | 7 | 2 | 6 | 3.4 | O=S(=O)(CCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)c1ccccc1 | 10.1021/jm00092a019 | |
135434015 | 203924 | 11 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 384 | 6 | 1 | 5 | 2.6 | CN(C(=O)CCCOc1ccc2c(c1)CN1CC(=O)NC1=N2)C1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL69139 | 203924 | 11 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 384 | 6 | 1 | 5 | 2.6 | CN(C(=O)CCCOc1ccc2c(c1)CN1CC(=O)NC1=N2)C1CCCCC1 | 10.1021/jm00092a019 | |
14281041 | 206983 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 287 | 5 | 3 | 5 | 2.3 | CC(O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL91359 | 206983 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 287 | 5 | 3 | 5 | 2.3 | CC(O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
14280990 | 106131 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 287 | 5 | 3 | 5 | 2.0 | O=C(O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL313463 | 106131 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 287 | 5 | 3 | 5 | 2.0 | O=C(O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
135409400 | 204901 | 77 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 255 | 0 | 1 | 3 | 1.9 | O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1 | 10.1021/jm00092a019 | |
CHEMBL760 | 204901 | 77 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 255 | 0 | 1 | 3 | 1.9 | O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1 | 10.1021/jm00092a019 | |
15005606 | 206557 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 366 | 6 | 3 | 4 | 3.9 | O=C(CCCCc1ccc2[nH]c3nc(O)nc-3cc2c1)NC1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL88707 | 206557 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 366 | 6 | 3 | 4 | 3.9 | O=C(CCCCc1ccc2[nH]c3nc(O)nc-3cc2c1)NC1CCCCC1 | 10.1021/jm00092a019 | |
14281012 | 106009 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 368 | 5 | 1 | 6 | 3.0 | Cn1c(O)nc2nc3ccc(OCCCC(=O)N4CCCCC4)cc3cc21 | 10.1021/jm00092a019 | |
CHEMBL313282 | 106009 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 368 | 5 | 1 | 6 | 3.0 | Cn1c(O)nc2nc3ccc(OCCCC(=O)N4CCCCC4)cc3cc21 | 10.1021/jm00092a019 | |
14281011 | 206815 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 354 | 5 | 2 | 5 | 2.9 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)N1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL90414 | 206815 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 354 | 5 | 2 | 5 | 2.9 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)N1CCCCC1 | 10.1021/jm00092a019 | |
15005605 | 206558 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 380 | 6 | 2 | 4 | 4.3 | CN(C(=O)CCCCc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL88708 | 206558 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 380 | 6 | 2 | 4 | 4.3 | CN(C(=O)CCCCc1ccc2[nH]c3nc(O)nc-3cc2c1)C1CCCCC1 | 10.1021/jm00092a019 | |
15005586 | 106924 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 275 | 4 | 4 | 6 | 0.5 | OCC(O)COc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL314763 | 106924 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 275 | 4 | 4 | 6 | 0.5 | OCC(O)COc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
15005565 | 206904 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 329 | 6 | 2 | 6 | 2.9 | CC(C)OC(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL90881 | 206904 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 329 | 6 | 2 | 6 | 2.9 | CC(C)OC(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
14281001 | 207147 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 420 | 6 | 3 | 5 | 4.0 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00092a019 | |
CHEMBL92264 | 207147 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 420 | 6 | 3 | 5 | 4.0 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 | 10.1021/jm00092a019 | |
14281010 | 206999 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 410 | 6 | 1 | 6 | 4.2 | CN(C(=O)CCCOc1ccc2nc3nc(O)n(C)c3cc2c1)C1CCCCCC1 | 10.1021/jm00092a019 | |
CHEMBL91422 | 206999 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 410 | 6 | 1 | 6 | 4.2 | CN(C(=O)CCCOc1ccc2nc3nc(O)n(C)c3cc2c1)C1CCCCCC1 | 10.1021/jm00092a019 | |
14281011 | 206815 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 354 | 5 | 2 | 5 | 2.9 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)N1CCCCC1 | 10.1021/jm00092a019 | |
CHEMBL90414 | 206815 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) |
ChEMBL | 354 | 5 | 2 | 5 | 2.9 | O=C(CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1)N1CCCCC1 | 10.1021/jm00092a019 | |
440317 | 21748 | 17 | None | -2 | 4 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 523 | 8 | 7 | 14 | -1.5 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O | 10.1021/jm020046y | |
CHEMBL131890 | 21748 | 17 | None | -2 | 4 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) |
ChEMBL | 523 | 8 | 7 | 14 | -1.5 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O | 10.1021/jm020046y | |
15005591 | 206506 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 282 | 5 | 2 | 5 | 2.8 | N#CCCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL88377 | 206506 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 282 | 5 | 2 | 5 | 2.8 | N#CCCCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
15005580 | 206773 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 300 | 5 | 3 | 5 | 1.7 | CNC(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 | |
CHEMBL90168 | 206773 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) |
ChEMBL | 300 | 5 | 3 | 5 | 1.7 | CNC(=O)CCCOc1ccc2[nH]c3nc(O)nc-3cc2c1 | 10.1021/jm00092a019 |
Showing 1 to 50 of 1,175 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
44443919 | 94416 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 553 | 14 | 6 | 13 | 0.2 | CCCCNc1nc(SCCC)nc2c1nnn2[C@@H]1O[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 | ||
CHEMBL251024 | 94416 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 553 | 14 | 6 | 13 | 0.2 | CCCCNc1nc(SCCC)nc2c1nnn2[C@@H]1O[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 | ||
1776 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2016.04.030 | ||
5006 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2016.04.030 | ||
9854012 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2016.04.030 | ||
CHEMBL334966 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2016.04.030 | ||
DB06441 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2016.04.030 | ||
1776 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 (unknown origin)Antagonist activity at P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/acs.jmedchem.5b01972 | ||
5006 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 (unknown origin)Antagonist activity at P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/acs.jmedchem.5b01972 | ||
9854012 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 (unknown origin)Antagonist activity at P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/acs.jmedchem.5b01972 | ||
CHEMBL334966 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 (unknown origin)Antagonist activity at P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/acs.jmedchem.5b01972 | ||
DB06441 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Antagonist activity at P2Y12 (unknown origin)Antagonist activity at P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/acs.jmedchem.5b01972 | ||
1776 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2022.128837 | ||
5006 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2022.128837 | ||
9854012 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2022.128837 | ||
CHEMBL334966 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2022.128837 | ||
DB06441 | 787 | 38 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1016/j.bmcl.2022.128837 | ||
44443921 | 168754 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 551 | 14 | 6 | 12 | 0.8 | CCCCNc1nc(SCCC)nc2c1nnn2[C@@H]1C[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 | ||
CHEMBL437204 | 168754 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 551 | 14 | 6 | 12 | 0.8 | CCCCNc1nc(SCCC)nc2c1nnn2[C@@H]1C[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 | ||
10557443 | 10225 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 783 | 13 | 7 | 14 | 3.1 | O=P(O)(OC[C@H]1O[C@@H](n2cnc3c(NCC(F)(F)F)nc(SCCC(F)(F)F)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1016/j.bmcl.2016.04.030 | ||
CHEMBL1160364 | 10225 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodAntagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method |
ChEMBL | 783 | 13 | 7 | 14 | 3.1 | O=P(O)(OC[C@H]1O[C@@H](n2cnc3c(NCC(F)(F)F)nc(SCCC(F)(F)F)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1016/j.bmcl.2016.04.030 | ||
66575818 | 114069 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysisDisplacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis |
ChEMBL | 458 | 8 | 2 | 6 | 4.8 | CCCC(=O)c1cnn(-c2ccc(NC(=O)c3cn(CC(=O)O)c4ccc(C)cc34)cc2)c1C | 10.1021/jm500588w | ||
CHEMBL3326907 | 114069 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysisDisplacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis |
ChEMBL | 458 | 8 | 2 | 6 | 4.8 | CCCC(=O)c1cnn(-c2ccc(NC(=O)c3cn(CC(=O)O)c4ccc(C)cc34)cc2)c1C | 10.1021/jm500588w | ||
44554515 | 111931 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Antagonist activity P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation after 5 to 90 mins by spectrophotometric analysisAntagonist activity P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation after 5 to 90 mins by spectrophotometric analysis |
ChEMBL | 526 | 9 | 1 | 8 | 4.0 | CCCC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)C3(c4ccccc4)CC3)CC2)nc1SC | 10.1016/j.bmcl.2014.04.001 | ||
CHEMBL3288123 | 111931 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Antagonist activity P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation after 5 to 90 mins by spectrophotometric analysisAntagonist activity P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation after 5 to 90 mins by spectrophotometric analysis |
ChEMBL | 526 | 9 | 1 | 8 | 4.0 | CCCC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)C3(c4ccccc4)CC3)CC2)nc1SC | 10.1016/j.bmcl.2014.04.001 | ||
49764561 | 190136 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 601 | 12 | 2 | 9 | 3.1 | CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2nc(-c3ccccc3)sc2N2CC[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5173489 | 190136 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 601 | 12 | 2 | 9 | 3.1 | CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2nc(-c3ccccc3)sc2N2CC[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
49764180 | 190537 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 524 | 9 | 3 | 7 | 2.2 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5179719 | 190537 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 524 | 9 | 3 | 7 | 2.2 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
46931928 | 190835 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 600 | 10 | 3 | 7 | 3.0 | CCCCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(P(=O)(O)O)cc2)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5184268 | 190835 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 600 | 10 | 3 | 7 | 3.0 | CCCCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(P(=O)(O)O)cc2)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
49763085 | 191434 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 622 | 10 | 3 | 9 | 1.9 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2nc(-c3ccccc3)sc2N2CCN(C)CC2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5192953 | 191434 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 622 | 10 | 3 | 9 | 1.9 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2nc(-c3ccccc3)sc2N2CCN(C)CC2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
49764183 | 191591 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 572 | 8 | 3 | 7 | 2.3 | CCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(P(=O)(O)O)cc2)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5195237 | 191591 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 572 | 8 | 3 | 7 | 2.3 | CCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(P(=O)(O)O)cc2)NC(=O)c2csc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
49763087 | 192115 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 609 | 13 | 3 | 8 | 3.4 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2nc(-c3ccccc3)sc2N(C)CCCC)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5203416 | 192115 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting methodDisplacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method |
ChEMBL | 609 | 13 | 3 | 8 | 3.4 | CCCCOC(=O)N1CCN(C(=O)[C@H](CP(=O)(O)O)NC(=O)c2nc(-c3ccccc3)sc2N(C)CCCC)CC1 | 10.1016/j.ejmech.2021.113924 | ||
15983053 | 92090 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) expressed in CHO cell membrane after 1 hr by scintillation counting analysisDisplacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) expressed in CHO cell membrane after 1 hr by scintillation counting analysis |
ChEMBL | 476 | 7 | 1 | 8 | 2.2 | CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccc(Cl)cc3)C2)nc1C | 10.1021/jm400820m | ||
CHEMBL2419485 | 92090 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) expressed in CHO cell membrane after 1 hr by scintillation counting analysisDisplacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) expressed in CHO cell membrane after 1 hr by scintillation counting analysis |
ChEMBL | 476 | 7 | 1 | 8 | 2.2 | CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccc(Cl)cc3)C2)nc1C | 10.1021/jm400820m | ||
66854978 | 191282 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting methodDisplacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting method |
ChEMBL | 784 | 14 | 3 | 11 | 1.1 | CCOC(=O)N1CCN(C(=O)[C@H](CCNS(=O)(=O)C(F)(F)F)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5190693 | 191282 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting methodDisplacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting method |
ChEMBL | 784 | 14 | 3 | 11 | 1.1 | CCOC(=O)N1CCN(C(=O)[C@H](CCNS(=O)(=O)C(F)(F)F)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
87180479 | 192360 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting methodDisplacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting method |
ChEMBL | 719 | 16 | 3 | 10 | 1.7 | CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NCC(F)F)n(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
CHEMBL5207212 | 192360 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | Displacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting methodDisplacement of [33P]2MeSADP from human P2Y12 expressed in CHO cell membranes preincubated for 15 mins followed by [33P]2MeSADP addition and measured after 20 mins by microbeta scintillation counting method |
ChEMBL | 719 | 16 | 3 | 10 | 1.7 | CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NCC(F)F)n(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2021.113924 | ||
1765 | 3817 | 98 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1016/j.bmcl.2022.128837 | ||
4184 | 3817 | 98 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1016/j.bmcl.2022.128837 | ||
9871419 | 3817 | 98 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1016/j.bmcl.2022.128837 | ||
CHEMBL398435 | 3817 | 98 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1016/j.bmcl.2022.128837 | ||
DB08816 | 3817 | 98 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Inhibition of P2Y12 (unknown origin)Inhibition of P2Y12 (unknown origin) |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1016/j.bmcl.2022.128837 | ||
44443917 | 94382 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 552 | 14 | 6 | 12 | 0.8 | CCCCNc1nc(SCCC)nc2c1ncn2[C@@H]1O[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 | ||
CHEMBL250832 | 94382 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | Antagonist activity at human P2Y12 by aggregation assayAntagonist activity at human P2Y12 by aggregation assay |
ChEMBL | 552 | 14 | 6 | 12 | 0.8 | CCCCNc1nc(SCCC)nc2c1ncn2[C@@H]1O[C@H](/C=C/C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b01972 |
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