Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
4064 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
4064 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 22343749 | |
42607474 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
42607474 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 22343749 | |
CHEMBL582985 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
CHEMBL582985 | 2435 | 0 | None | -3 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 22343749 | |
4064 | 2435 | 0 | None | 1 | 3 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
42607474 | 2435 | 0 | None | 1 | 3 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
CHEMBL582985 | 2435 | 0 | None | 1 | 3 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 525 | 25 | 4 | 8 | 4.7 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O | 16460680 | |
12947 | 4114 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 582 | 9 | 2 | 4 | 6.0 | OC(=O)C1(CCN(CC1)C(=O)C2=CC=C(C=C2)C3=CC(Cl)=CC=C3)NC(=O)CC4=CC=C(OCC5=CC=CC=C5)C=C4 | 21193033 | |
169422747 | 4114 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | UnclassifiedUnclassified |
Guide to Pharmacology | 582 | 9 | 2 | 4 | 6.0 | OC(=O)C1(CCN(CC1)C(=O)C2=CC=C(C=C2)C3=CC(Cl)=CC=C3)NC(=O)CC4=CC=C(OCC5=CC=CC=C5)C=C4 | 21193033 |
Showing 1 to 11 of 11 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
78319665 | 180493 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4753103 | 180493 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
78319665 | 180493 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4753103 | 180493 | 0 | None | - | 0 | Human | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
78319665 | 180493 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4753103 | 180493 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
78319665 | 180493 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4753103 | 180493 | 0 | None | - | 0 | Mouse | 9.1 | pEC50 | = | 9.1 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
90322737 | 181491 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 537 | 25 | 3 | 8 | 5.1 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4764776 | 181491 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 537 | 25 | 3 | 8 | 5.1 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
137659825 | 159385 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 699 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4100630 | 159385 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 699 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
145948884 | 167500 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.7 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
CHEMBL4299658 | 167500 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.7 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H]1OCCC[C@H]1OP(=O)(O)OC[C@@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
137659825 | 159385 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 699 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4100630 | 159385 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 699 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(I)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137660195 | 159154 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 641 | 17 | 3 | 9 | 5.8 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4098171 | 159154 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 641 | 17 | 3 | 9 | 5.8 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
78319747 | 140655 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 601 | 22 | 3 | 9 | 5.2 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
CHEMBL3814763 | 140655 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 601 | 22 | 3 | 9 | 5.2 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
90322737 | 181491 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 537 | 25 | 3 | 8 | 5.1 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4764776 | 181491 | 0 | None | - | 0 | Mouse | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 537 | 25 | 3 | 8 | 5.1 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](COC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
162666591 | 182347 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 561 | 26 | 3 | 8 | 5.1 | C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4784581 | 182347 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 561 | 26 | 3 | 8 | 5.1 | C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
137660195 | 159154 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 641 | 17 | 3 | 9 | 5.8 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4098171 | 159154 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 641 | 17 | 3 | 9 | 5.8 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
78319747 | 140655 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 601 | 22 | 3 | 9 | 5.2 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
CHEMBL3814763 | 140655 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 601 | 22 | 3 | 9 | 5.2 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@H]1OCCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
137640237 | 156807 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4071116 | 156807 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137637812 | 156042 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 591 | 17 | 3 | 9 | 4.6 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4062480 | 156042 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 591 | 17 | 3 | 9 | 4.6 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
127051444 | 140682 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 663 | 16 | 3 | 10 | 5.3 | N[C@@H](COP(=O)(O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
CHEMBL3815141 | 140682 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 663 | 16 | 3 | 10 | 5.3 | N[C@@H](COP(=O)(O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
162666591 | 182347 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 561 | 26 | 3 | 8 | 5.1 | C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
CHEMBL4784581 | 182347 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 561 | 26 | 3 | 8 | 5.1 | C#CCOC[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
137637812 | 156042 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 591 | 17 | 3 | 9 | 4.6 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4062480 | 156042 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 591 | 17 | 3 | 9 | 4.6 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(F)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137640237 | 156807 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4071116 | 156807 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
127051444 | 140682 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 663 | 16 | 3 | 10 | 5.3 | N[C@@H](COP(=O)(O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
CHEMBL3815141 | 140682 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assayAgonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay |
ChEMBL | 663 | 16 | 3 | 10 | 5.3 | N[C@@H](COP(=O)(O)OC[C@H]1OCCC[C@H]1OC(=O)CCc1ccccc1OCc1cccc(Oc2ccc(Cl)cc2)c1)C(=O)O | 10.1021/acs.jmedchem.5b01925 | ||
137637516 | 155957 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 567 | 21 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCCCCCCOc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4061305 | 155957 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 567 | 21 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCCCCCCOc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137646672 | 157678 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2Cl)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4081667 | 157678 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2Cl)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137637516 | 155957 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 567 | 21 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCCCCCCOc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4061305 | 155957 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 567 | 21 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCCCCCCOc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
137646672 | 157678 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2Cl)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 | ||
CHEMBL4081667 | 157678 | 0 | None | - | 0 | Mouse | 5.9 | pEC50 | = | 5.9 | Binding | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hrAgonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr |
ChEMBL | 607 | 17 | 3 | 9 | 5.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2Cl)c1)C(=O)O | 10.1021/acs.jmedchem.7b00693 |
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