GproteinDb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1067	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	119	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	1262	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	5410	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	6992099	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	CHEMBL96	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	DB02530	1679	121	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	11701095	188121	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	CHEMBL504482	188121	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	24895101	171473	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	CHEMBL447171	171473	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	24895106	170325	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	CHEMBL445449	170325	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	16686147	2264	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	7705	2264	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	CHEMBL448343	2264	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	DB11920	2264	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	1067	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	119	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1262	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	5410	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	6992099	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	CHEMBL96	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	DB02530	1679	121	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1064	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	3428	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	44602	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	6918881	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	CHEMBL301742	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB00181	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB08891	562	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	1069	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	1069	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	107699	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	107699	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	CHEMBL40157	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	CHEMBL40157	879	40	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	1081	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	5381	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	6335948	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	1075	3499	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	5311429	3499	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	86294992	3499	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	CHEMBL1895916	3499	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	1072	884	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	3429	884	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	5310936	884	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	1078	3402	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	122150	3402	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	CHEMBL312403	3402	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	1068	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1564	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	CHEMBL1256573	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1067	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	119	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	1262	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	5410	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	6992099	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	CHEMBL96	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	DB02530	1679	121	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	10154248	881	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1066	881	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	CHEMBL113553	881	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1074	887	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	6324595	887	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909011	887	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1073	885	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	5311043	885	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909010	885	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1070	882	9	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1090	882	9	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	197584	882	9	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	CHEMBL1213187	882	9	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1071	883	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281
	9800175	883	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	5446	1838	50	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
	6604928	1838	50	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
	CHEMBL392394	1838	50	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
	9964332	9947	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL115162	9947	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
	9813169	9690	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	CHEMBL113613	9690	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	28560001	109916	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
	659968	109916	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
	CHEMBL324407	109916	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
	9883500	141797	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
	CHEMBL38856	141797	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
	10377028	108120	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
	CHEMBL320533	108120	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
	58227083	124090	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
	CHEMBL3640615	124090	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
	9920531	109832	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL323887	109832	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
	10352529	110178	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
	CHEMBL325932	110178	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
	28559746	9548	46	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
	5230	9548	46	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL112710	9548	46	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
	9920471	9372	2	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL111890	9372	2	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
	9964768	109886	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
	CHEMBL324244	109886	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
	58227084	124091	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
	CHEMBL3640616	124091	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
	9815542	9481	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL112408	9481	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
	9878233	110812	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL326622	110812	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
	10105390	9486	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
	CHEMBL112460	9486	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
	10466591	9530	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
	CHEMBL112639	9530	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
	44341174	9678	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
	CHEMBL113540	9678	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
	9898878	110176	15	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL325921	110176	15	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
	130023	9684	8	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL113571	9684	8	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
	9878836	10031	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL115664	10031	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
	9923821	9887	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	CHEMBL114812	9887	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	9877786	9554	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL112741	9554	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
	1069	879	40	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
	107699	879	40	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
	CHEMBL40157	879	40	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
	9856380	9746	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL114027	9746	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
	10219796	9363	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
	CHEMBL111817	9363	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
	15134818	9453	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL112291	9453	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
	58227082	124092	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
	CHEMBL3640617	124092	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
	10466077	9484	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
	CHEMBL112451	9484	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
	10082524	9796	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	CHEMBL114288	9796	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	9877609	109972	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
	CHEMBL324694	109972	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
	10219657	9536	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
	CHEMBL112658	9536	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
	9834206	96291	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
	CHEMBL264396	96291	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
	130021	9563	29	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL112797	9563	29	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
	10058852	9438	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
	CHEMBL112213	9438	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
	130022	9470	30	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	CHEMBL112362	9470	30	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	10465678	168766	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
	CHEMBL441821	168766	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
	121956	9436	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
	CHEMBL112203	9436	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
	10354046	9397	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	CHEMBL112019	9397	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	10376775	9653	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	CHEMBL113435	9653	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	10398919	9909	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	CHEMBL114918	9909	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	15134810	9444	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
	CHEMBL112248	9444	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
	10243064	9472	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	CHEMBL112376	9472	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	10331452	109702	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
	CHEMBL323713	109702	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
	1070	882	9	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	1090	882	9	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	197584	882	9	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	CHEMBL1213187	882	9	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	10059083	9529	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
	CHEMBL112638	9529	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
	10084142	9633	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	CHEMBL113305	9633	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	5310935	9634	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	CHEMBL113308	9634	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
	9882973	108725	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	CHEMBL321688	108725	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	9942295	109245	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
	CHEMBL322965	109245	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
	10105202	9978	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	CHEMBL115354	9978	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
	10059688	162859	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
	CHEMBL419582	162859	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
	58227081	124093	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
	CHEMBL3640618	124093	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
	9813635	9768	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	CHEMBL114128	9768	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
	1070	882	9	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	1090	882	9	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	197584	882	9	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
	CHEMBL1213187	882	9	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025

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Main reference

Ligand source activities (1 row/activity)