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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	218819	3H-LY341495	0	Human	Binding	pKi	=	125.60	6.90	-4	3	-	PDSP KiDatabase	185.1	2	3	3	-0.49	NC1(C(=O)O)CCC2C(C(=O)O)C21	-
(+)-MCPG	2475	None	35	Human	Binding	pKi	None	-	3.80	-6	8	Unclassified	Guide to Pharmacology	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/10530814
(1S,3R)-ACPD	33	None	30	Human	Binding	pKi	None	-	4.70	-12	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10530814
(1S,3R)-ACPD	33	None	30	Rat	Binding	pKi	None	-	4.80	-10	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10884552
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	8000.00	5.10	-10	15	Concentration for half maximal activation of metabotropic glutamate mGluR3 in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(2R,3R)-APDC	73	None	32	Human	Binding	pKi	None	-	5.30	1	5	Unclassified	Guide to Pharmacology	174.1	2	4	4	-1.78	N[C@@]1(C(=O)O)CN[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/10530814
1S, 3R-ACPD	218660	Functional	0	Human	Binding	pKi	=	8000.00	5.10	-1	7	-	PDSP KiDatabase	173.1	2	3	3	-0.35	NC1(C(=O)O)CCC(C(=O)O)C1	-
CHEMBL108735	7529	None	0	Rat	Binding	IC50	=	1300.00	5.89	-	2	Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 cells	ChEMBL	353.1	5	3	4	2.67	NC(C(=O)O)[C@@H]1[C@@H](C(=O)O)[C@@H]1CC1c2ccccc2Oc2ccccc21	https://dx.doi.org/10.1016/s0960-894x(01)00656-4
CHEMBL140197	31349	None	0	Human	Binding	Ki	=	3.00	8.52	7	7	Binding affinity towards metabotropic glutamate receptor 3 was determined	ChEMBL	175.0	3	4	4	-1.91	N[C@H](C(=O)O)[C@H]1[C@@H](O)[C@@H]1C(=O)O	https://dx.doi.org/10.1021/jm030967o
CHEMBL144151	35826	None	1	Rat	Binding	Ki	=	4.11	8.39	-1	4	Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligand	ChEMBL	353.1	5	3	4	2.82	N[C@@](CC1c2ccccc2Oc2ccccc21)(C(=O)O)[C@H]1C[C@@H]1C(=O)O	https://dx.doi.org/10.1021/jm000346k
CHEMBL183956	66135	None	0	Rat	Binding	Ki	=	88.10	7.05	-2	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	233.1	3	3	4	-0.77	CO[C@@H]1C[C@@H]2[C@H]([C@]1(N)C(=O)O)[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL185210	66478	None	0	Rat	Binding	Ki	=	5.43	8.27	-2	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	359.1	5	3	4	1.95	N[C@@]1(C(=O)O)[C@H](OCc2ccc3ccccc3c2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL185822	66774	None	0	Rat	Binding	Ki	=	67.10	7.17	-2	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	219.1	2	4	4	-1.43	N[C@@]1(C(=O)O)[C@H](O)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL186214	66873	None	0	Rat	Binding	Ki	=	15.90	7.80	-2	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	309.1	5	3	4	0.80	N[C@@]1(C(=O)O)[C@H](OCc2ccccc2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL186630	66958	None	0	Rat	Binding	Ki	=	3.00	8.52	-1	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	345.1	5	3	4	1.07	N[C@@]1(C(=O)O)[C@H](OCc2ccc(F)c(F)c2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL189814	67581	None	0	Rat	Binding	Ki	=	4.77	8.32	-1	2	Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008	ChEMBL	343.1	5	3	4	1.45	N[C@@]1(C(=O)O)[C@H](OCc2ccc(Cl)cc2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O	https://dx.doi.org/10.1021/jm0400294
CHEMBL192977	69397	None	1	Human	Binding	Ki	=	146.00	6.84	6	2	Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3	ChEMBL	199.1	2	3	3	-0.24	C[C@@H]1C[C@H]2[C@H](C(=O)O)[C@H]2[C@]1(N)C(=O)O	https://dx.doi.org/10.1021/jm040222y
CHEMBL218710	83279	None	1	Human	Binding	Ki	=	0.17	9.77	5	3	Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells	ChEMBL	219.0	2	3	4	-1.77	N[C@@]1(C(=O)O)C[S+]([O-])[C@H]2[C@H](C(=O)O)[C@H]21	https://dx.doi.org/10.1021/jm060917u
CHEMBL218710	83279	None	1	Human	Binding	Ki	=	447.00	6.35	5	3	Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells	ChEMBL	219.0	2	3	4	-1.77	N[C@@]1(C(=O)O)C[S+]([O-])[C@H]2[C@H](C(=O)O)[C@H]21	https://dx.doi.org/10.1021/jm060917u
CHEMBL2204437	83633	None	0	Human	Binding	IC50	=	3801.89	5.42	-	1	Negative allosteric modulation of mGlu3 assessed as thallium flux through GIRK channels by cell-based assay	ChEMBL	335.2	2	1	3	2.69	COc1ccc(C#Cc2ccc(C(=O)N3CCC(O)CC3)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.04.112

Showing 1 to 20 of 245 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)