GproteinDb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1499	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	536	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	CHEMBL434	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	DB01064	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	1499	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	536	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	CHEMBL434	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	DB01064	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	2367	950	83	None	-1148	5	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	20022913
	6167	950	83	None	-1148	5	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	20022913
	726	950	83	None	-1148	5	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	20022913
	CHEMBL107	950	83	None	-1148	5	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	20022913
	DB01394	950	83	None	-1148	5	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	20022913
	12423	3636	0	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	804	9	11	18	-2.9	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O	22616809
	442089	3636	0	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	804	9	11	18	-2.9	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O	22616809
	CHEMBL444122	3636	0	None	-	1	Human	3.5	pEC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	804	9	11	18	-2.9	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O	22616809
	138107041	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	276	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	447043	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	6510	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	CHEMBL529	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	DB00207	555	63	None	-562	3	Human	4.1	pEC50	=	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	749	7	5	14	1.9	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O	30011231
	12424	2340	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23214402
	44398561	2340	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23214402
	CHEMBL434535	2340	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23214402
	10362	225	65	None	-1096	2	Human	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	2	3	2.3	OC(=O)/C=C(\C=C\C1(O)C(=CC(=O)CC1(C)C)C)/C	25844797
	5375199	225	65	None	-1096	2	Human	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	2	3	2.3	OC(=O)/C=C(\C=C\C1(O)C(=CC(=O)CC1(C)C)C)/C	25844797
	CHEMBL379808	225	65	None	-1096	2	Human	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	264	3	2	3	2.3	OC(=O)/C=C(\C=C\C1(O)C(=CC(=O)CC1(C)C)C)/C	25844797

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)