GproteinDb

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Ligand source activities (1 row/activity)

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Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	6-Methylflavone	163	None	0	Human	Functional	pIC50	=	-	4.66	-	1	Unclassified	Guide to Pharmacology	236.1	1	0	2	3.77	Cc1ccc2oc(-c3ccccc3)cc(=O)c2c1	https://pubmed.ncbi.nlm.nih.gov/24722342
	datiscetin	1326	None	0	Human	Functional	pEC50	=	-	4.38	-4	2	Unclassified	Guide to Pharmacology	286.0	1	4	6	2.28	O=c1c(O)c(-c2ccccc2O)oc2cc(O)cc(O)c12	https://pubmed.ncbi.nlm.nih.gov/24117141
	(-)-Epicatechin	1572	None	60	Human	Functional	pEC50	=	-	3.38	-13	2	Unclassified	Guide to Pharmacology	290.1	1	5	6	1.55	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@H](O)C2	https://pubmed.ncbi.nlm.nih.gov/21272567
	epicatechin gallate	1573	None	57	Human	Functional	pEC50	=	-	4.67	-	3	Unclassified	Guide to Pharmacology	442.1	3	7	10	2.53	O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1	https://pubmed.ncbi.nlm.nih.gov/25273142
	epigallocatechin	1574	None	55	Human	Functional	pEC50	=	-	3.40	-	2	Unclassified	Guide to Pharmacology	306.1	1	6	7	1.25	Oc1cc(O)c2c(c1)O[C@H](c1cc(O)c(O)c(O)c1)[C@H](O)C2	https://pubmed.ncbi.nlm.nih.gov/21272567
	genistein	1784	None	76	Human	Functional	pEC50	=	-	4.31	-48	9	Unclassified	Guide to Pharmacology	270.1	1	3	5	2.58	O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12	https://pubmed.ncbi.nlm.nih.gov/21942422
	isoprenaline	2091	None	34	Human	Functional	pEC50	=	8.31	8.08	-63	49	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211.1	4	4	4	1.13	CC(C)NCC(O)c1ccc(O)c(O)c1	-
	isoprenaline	2091	None	34	Human	Functional	EC50	=	4.90	8.31	-63	49	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211.1	4	4	4	1.13	CC(C)NCC(O)c1ccc(O)c(O)c1	-
	luteolin	2386	None	74	Human	Functional	pEC50	=	-	5.14	-1	5	Unclassified	Guide to Pharmacology	286.0	1	4	6	2.28	O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	https://pubmed.ncbi.nlm.nih.gov/24117141
	naringenin	2736	None	0	Human	Functional	pEC50	=	-	4.48	-	1	Unclassified	Guide to Pharmacology	272.1	1	3	5	2.51	O=C1CC(c2ccc(O)cc2)Oc2cc(O)cc(O)c21	https://pubmed.ncbi.nlm.nih.gov/24117141
	phloretin	3110	None	68	Human	Functional	pEC50	=	-	4.38	-2	3	Unclassified	Guide to Pharmacology	274.1	4	4	5	2.32	O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O	https://pubmed.ncbi.nlm.nih.gov/24117141
	(±)-Equol	3140	None	0	Human	Functional	pEC50	=	-	4.25	-1	2	Unclassified	Guide to Pharmacology	242.1	1	2	3	2.82	Oc1ccc(C2COc3cc(O)ccc3C2)cc1	https://pubmed.ncbi.nlm.nih.gov/21942422
	scutellarein	3563	None	0	Human	Functional	pEC50	=	-	4.39	-	1	Unclassified	Guide to Pharmacology	286.0	1	4	6	2.28	O=c1cc(-c2ccc(O)cc2)oc2cc(O)c(O)c(O)c12	https://pubmed.ncbi.nlm.nih.gov/24117141
	theaflavin	3797	None	0	Human	Functional	pEC50	=	-	5.55	-	1	Unclassified	Guide to Pharmacology	564.1	2	9	12	2.21	O=c1c(O)cc([C@H]2Oc3cc(O)cc(O)c3C[C@H]2O)cc2c([C@H]3Oc4cc(O)cc(O)c4C[C@H]3O)cc(O)c(O)c12	https://pubmed.ncbi.nlm.nih.gov/25273142
	theaflavin-3′-O-gallate	3798	None	0	Human	Functional	pEC50	=	-	6.17	-	1	Unclassified	Guide to Pharmacology	716.1	4	11	16	3.19	O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(=O)c2c(O)c(O)cc([C@H]3Oc4cc(O)cc(O)c4C[C@H]3O)c2c1)c1cc(O)c(O)c(O)c1	https://pubmed.ncbi.nlm.nih.gov/25273142
	vanillin	3971	None	0	Human	Functional	pEC50	=	-	3.06	-1	3	Unclassified	Guide to Pharmacology	152.0	2	1	3	1.21	COc1cc(C=O)ccc1O	https://pubmed.ncbi.nlm.nih.gov/34307435

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