ADGRB3 (agrb3_human)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRB ADGRB3
GENE
ADGRB3 (BAI3, KIAA0550)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adhesion G protein-coupled receptor B3, Brain-specific angiogenesis inhibitor 3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
K
|
A
|
V
|
R
|
N
|
L
|
L
|
I
|
Y
|
10 |
I
|
F
|
S
|
T
|
Y
|
L
|
L
|
V
|
M
|
F
|
20 |
G
|
F
|
N
|
A
|
A
|
Q
|
D
|
F
|
W
|
C
|
30 |
S
|
T
|
L
|
V
|
K
|
G
|
V
|
I
|
Y
|
G
|
40 |
S
|
Y
|
S
|
V
|
S
|
E
|
M
|
F
|
P
|
K
|
50 |
N
|
F
|
T
|
N
|
C
|
T
|
W
|
T
|
L
|
E
|
60 |
N
|
P
|
D
|
P
|
T
|
K
|
Y
|
S
|
I
|
Y
|
70 |
L
|
K
|
F
|
S
|
K
|
K
|
D
|
L
|
S
|
C
|
80 |
S
|
N
|
F
|
S
|
L
|
L
|
A
|
Y
|
Q
|
F
|
90 |
D
|
H
|
F
|
S
|
H
|
E
|
K
|
I
|
K
|
D
|
100 |
L
|
L
|
R
|
K
|
N
|
H
|
S
|
I
|
M
|
Q
|
110 |
L
|
C
|
N
|
S
|
K
|
N
|
A
|
F
|
V
|
F
|
120 |
L
|
Q
|
Y
|
D
|
K
|
N
|
F
|
I
|
Q
|
I
|
130 |
R
|
R
|
V
|
F
|
P
|
T
|
N
|
F
|
P
|
G
|
140 |
L
|
Q
|
K
|
K
|
G
|
E
|
E
|
D
|
Q
|
K
|
150 |
S
|
F
|
F
|
E
|
F
|
L
|
V
|
L
|
N
|
K
|
160 |
V
|
S
|
P
|
S
|
Q
|
F
|
G
|
C
|
H
|
V
|
170 |
L
|
C
|
T
|
W
|
L
|
E
|
S
|
C
|
L
|
K
|
180 |
S
|
E
|
N
|
G
|
R
|
T
|
E
|
S
|
C
|
G
|
190 |
I
|
M
|
Y
|
T
|
K
|
C
|
T
|
C
|
P
|
Q
|
200 |
H
|
L
|
G
|
E
|
W
|
G
|
I
|
D
|
D
|
Q
|
210 |
S
|
L
|
I
|
L
|
L
|
N
|
N
|
V
|
V
|
L
|
220 |
P
|
L
|
N
|
E
|
Q
|
T
|
E
|
G
|
C
|
L
|
230 |
T
|
Q
|
E
|
L
|
Q
|
T
|
T
|
Q
|
V
|
C
|
240 |
N
|
L
|
T
|
R
|
E
|
A
|
K
|
R
|
P
|
P
|
250 |
K
|
E
|
E
|
F
|
G
|
M
|
M
|
G
|
D
|
H
|
260 |
T
|
I
|
K
|
S
|
Q
|
R
|
P
|
R
|
S
|
V
|
270 |
H
|
E
|
K
|
R
|
V
|
P
|
Q
|
E
|
Q
|
A
|
280 |
D
|
A
|
A
|
K
|
F
|
M
|
A
|
Q
|
T
|
G
|
290 |
E
|
S
|
G
|
V
|
E
|
E
|
W
|
S
|
Q
|
W
|
300 |
S
|
T
|
C
|
S
|
V
|
T
|
C
|
G
|
Q
|
G
|
310 |
S
|
Q
|
V
|
R
|
T
|
R
|
T
|
C
|
V
|
S
|
320 |
P
|
Y
|
G
|
T
|
H
|
C
|
S
|
G
|
P
|
L
|
330 |
R
|
E
|
S
|
R
|
V
|
C
|
N
|
N
|
T
|
A
|
340 |
L
|
C
|
P
|
V
|
H
|
G
|
V
|
W
|
E
|
E
|
350 |
W
|
S
|
P
|
W
|
S
|
L
|
C
|
S
|
F
|
T
|
360 |
C
|
G
|
R
|
G
|
Q
|
R
|
T
|
R
|
T
|
R
|
370 |
S
|
C
|
T
|
P
|
P
|
Q
|
Y
|
G
|
G
|
R
|
380 |
P
|
C
|
E
|
G
|
P
|
E
|
T
|
H
|
H
|
K
|
390 |
P
|
C
|
N
|
I
|
A
|
L
|
C
|
P
|
V
|
D
|
400 |
G
|
Q
|
W
|
Q
|
E
|
W
|
S
|
S
|
W
|
S
|
410 |
Q
|
C
|
S
|
V
|
T
|
C
|
S
|
N
|
G
|
T
|
420 |
Q
|
Q
|
R
|
S
|
R
|
Q
|
C
|
T
|
A
|
A
|
430 |
A
|
H
|
G
|
G
|
S
|
E
|
C
|
R
|
G
|
P
|
440 |
W
|
A
|
E
|
S
|
R
|
E
|
C
|
Y
|
N
|
P
|
450 |
E
|
C
|
T
|
A
|
N
|
G
|
Q
|
W
|
N
|
Q
|
460 |
W
|
G
|
H
|
W
|
S
|
G
|
C
|
S
|
K
|
S
|
470 |
C
|
D
|
G
|
G
|
W
|
E
|
R
|
R
|
I
|
R
|
480 |
T
|
C
|
Q
|
G
|
A
|
V
|
I
|
T
|
G
|
Q
|
490 |
Q
|
C
|
E
|
G
|
T
|
G
|
E
|
E
|
V
|
R
|
500 |
R
|
C
|
N
|
E
|
Q
|
R
|
C
|
P
|
A
|
P
|
510 |
Y
|
E
|
I
|
C
|
P
|
E
|
D
|
Y
|
L
|
M
|
520 |
S
|
M
|
V
|
W
|
K
|
R
|
T
|
P
|
A
|
G
|
530 |
D
|
L
|
A
|
F
|
N
|
Q
|
C
|
P
|
L
|
N
|
540 |
A
|
T
|
G
|
T
|
T
|
S
|
R
|
R
|
C
|
S
|
550 |
L
|
S
|
L
|
H
|
G
|
V
|
A
|
F
|
W
|
E
|
560 |
Q
|
P
|
S
|
F
|
A
|
R
|
C
|
I
|
S
|
N
|
570 |
E
|
Y
|
R
|
H
|
L
|
Q
|
H
|
S
|
I
|
K
|
580 |
E
|
H
|
L
|
A
|
K
|
G
|
Q
|
R
|
M
|
L
|
590 |
A
|
G
|
D
|
G
|
M
|
S
|
Q
|
V
|
T
|
K
|
600 |
T
|
L
|
L
|
D
|
L
|
T
|
Q
|
R
|
K
|
N
|
610 |
F
|
Y
|
A
|
G
|
D
|
L
|
L
|
M
|
S
|
V
|
620 |
E
|
I
|
L
|
R
|
N
|
V
|
T
|
D
|
T
|
F
|
630 |
K
|
R
|
A
|
S
|
Y
|
I
|
P
|
A
|
S
|
D
|
640 |
G
|
V
|
Q
|
N
|
F
|
F
|
Q
|
I
|
V
|
S
|
650 |
N
|
L
|
L
|
D
|
E
|
E
|
N
|
K
|
E
|
K
|
660 |
W
|
E
|
D
|
A
|
Q
|
Q
|
I
|
Y
|
P
|
G
|
670 |
S
|
I
|
E
|
L
|
M
|
Q
|
V
|
I
|
E
|
D
|
680 |
F
|
I
|
H
|
I
|
V
|
G
|
M
|
G
|
M
|
M
|
690 |
D
|
F
|
Q
|
N
|
S
|
Y
|
L
|
M
|
T
|
G
|
700 |
N
|
V
|
V
|
A
|
S
|
I
|
Q
|
K
|
L
|
P
|
710 |
A
|
A
|
S
|
V
|
L
|
T
|
D
|
I
|
N
|
F
|
720 |
P
|
M
|
K
|
G
|
R
|
K
|
G
|
M
|
V
|
D
|
730 |
W
|
A
|
R
|
N
|
S
|
E
|
D
|
R
|
V
|
V
|
740 |
I
|
P
|
K
|
S
|
I
|
F
|
T
|
P
|
V
|
S
|
750 |
S
|
K
|
E
|
L
|
D
|
E
|
S
|
S
|
V
|
F
|
760 |
V
|
L
|
G
|
A
|
V
|
L
|
Y
|
K
|
N
|
L
|
770 |
D
|
L
|
I
|
L
|
P
|
T
|
L
|
R
|
N
|
Y
|
780 |
T
|
V
|
I
|
N
|
S
|
K
|
I
|
I
|
V
|
V
|
790 |
T
|
I
|
R
|
P
|
E
|
P
|
K
|
T
|
T
|
D
|
800 |
S
|
F
|
L
|
E
|
I
|
E
|
L
|
A
|
H
|
L
|
810 |
A
|
N
|
G
|
T
|
L
|
N
|
P
|
Y
|
C
|
V
|
820 |
L
|
W
|
D
|
D
|
S
|
K
|
T
|
N
|
E
|
S
|
830 |
L
|
G
|
T
|
W
|
S
|
T
|
Q
|
G
|
C
|
K
|
840 |
T
|
V
|
L
|
T
|
D
|
A
|
S
|
H
|
T
|
K
|
850 |
C
|
L
|
C
|
D
|
R
|
L
|
S
|
T
|
F
|
A
|
860 |
I
|
L
|
A
|
Q
|
Q
|
P
|
R
|
E
|
I
|
I
|
870 |
TM1 | |||||||||
M
|
E
|
S
|
S
|
G
|
T
|
P
|
S
|
V
|
T
|
880 |
L
|
I
|
V
|
G
|
S
|
G
|
L
|
S
|
C
|
L
|
890 |
A
|
L
|
I
|
T
|
L
|
A
|
V
|
V
|
Y
|
A
|
900 |
ICL1 | TM2 | ||||||||
A
|
L
|
W
|
R
|
Y
|
I
|
R
|
S
|
E
|
R
|
910 |
S
|
I
|
I
|
L
|
I
|
N
|
F
|
C
|
L
|
S
|
920 |
I
|
I
|
S
|
S
|
N
|
I
|
L
|
I
|
L
|
V
|
930 |
ECL1 | |||||||||
G
|
Q
|
T
|
Q
|
T
|
H
|
N
|
K
|
S
|
I
|
940 |
TM3 | |||||||||
C
|
T
|
T
|
T
|
T
|
A
|
F
|
L
|
H
|
F
|
950 |
F
|
F
|
L
|
A
|
S
|
F
|
C
|
W
|
V
|
L
|
960 |
T
|
E
|
A
|
W
|
Q
|
S
|
Y
|
M
|
A
|
V
|
970 |
ICL2 | |||||||||
T
|
G
|
K
|
I
|
R
|
T
|
R
|
L
|
I
|
R
|
980 |
TM4 | |||||||||
K
|
R
|
F
|
L
|
C
|
L
|
G
|
W
|
G
|
L
|
990 |
P
|
A
|
L
|
V
|
V
|
A
|
T
|
S
|
V
|
G
|
1000 |
ECL2 | |||||||||
F
|
T
|
R
|
T
|
K
|
G
|
Y
|
G
|
T
|
D
|
1010 |
H
|
Y
|
C
|
W
|
L
|
S
|
L
|
E
|
G
|
G
|
1020 |
TM5 | |||||||||
L
|
L
|
Y
|
A
|
F
|
V
|
G
|
P
|
A
|
A
|
1030 |
A
|
V
|
V
|
L
|
V
|
N
|
M
|
V
|
I
|
G
|
1040 |
I
|
L
|
V
|
F
|
N
|
K
|
L
|
V
|
S
|
R
|
1050 |
ICL3 | |||||||||
D
|
G
|
I
|
L
|
D
|
K
|
K
|
L
|
K
|
H
|
1060 |
R
|
A
|
G
|
Q
|
M
|
S
|
E
|
P
|
H
|
S
|
1070 |
G
|
L
|
T
|
L
|
K
|
C
|
A
|
K
|
C
|
G
|
1080 |
V
|
V
|
S
|
T
|
T
|
A
|
L
|
S
|
A
|
T
|
1090 |
TM6 | |||||||||
T
|
A
|
S
|
N
|
A
|
M
|
A
|
S
|
L
|
W
|
1100 |
S
|
S
|
C
|
V
|
V
|
L
|
P
|
L
|
L
|
A
|
1110 |
L
|
T
|
W
|
M
|
S
|
A
|
V
|
L
|
A
|
M
|
1120 |
ECL3 | TM7 | ||||||||
T
|
D
|
K
|
R
|
S
|
I
|
L
|
F
|
Q
|
I
|
1130 |
L
|
F
|
A
|
V
|
F
|
D
|
S
|
L
|
Q
|
G
|
1140 |
F
|
V
|
I
|
V
|
M
|
V
|
H
|
C
|
I
|
L
|
1150 |
H8 | |||||||||
R
|
R
|
E
|
V
|
Q
|
D
|
A
|
F
|
R
|
C
|
1160 |
R
|
L
|
R
|
N
|
C
|
Q
|
D
|
P
|
I
|
N
|
1170 |
C-term | |||||||||
A
|
D
|
S
|
S
|
S
|
S
|
F
|
P
|
N
|
G
|
1180 |
H
|
A
|
Q
|
I
|
M
|
T
|
D
|
F
|
E
|
K
|
1190 |
D
|
V
|
D
|
I
|
A
|
C
|
R
|
S
|
V
|
L
|
1200 |
H
|
K
|
D
|
I
|
G
|
P
|
C
|
R
|
A
|
A
|
1210 |
T
|
I
|
T
|
G
|
T
|
L
|
S
|
R
|
I
|
S
|
1220 |
L
|
N
|
D
|
D
|
E
|
E
|
E
|
K
|
G
|
T
|
1230 |
N
|
P
|
E
|
G
|
L
|
S
|
Y
|
S
|
T
|
L
|
1240 |
P
|
G
|
N
|
V
|
I
|
S
|
K
|
V
|
I
|
I
|
1250 |
Q
|
Q
|
P
|
T
|
G
|
L
|
H
|
M
|
P
|
M
|
1260 |
S
|
M
|
N
|
E
|
L
|
S
|
N
|
P
|
C
|
L
|
1270 |
K
|
K
|
E
|
N
|
S
|
E
|
L
|
R
|
R
|
T
|
1280 |
V
|
Y
|
L
|
C
|
T
|
D
|
D
|
N
|
L
|
R
|
1290 |
G
|
A
|
D
|
M
|
D
|
I
|
V
|
H
|
P
|
Q
|
1300 |
E
|
R
|
M
|
M
|
E
|
S
|
D
|
Y
|
I
|
V
|
1310 |
M
|
P
|
R
|
S
|
S
|
V
|
N
|
N
|
Q
|
P
|
1320 |
S
|
M
|
K
|
E
|
E
|
S
|
K
|
M
|
N
|
I
|
1330 |
G
|
M
|
E
|
T
|
L
|
P
|
H
|
E
|
R
|
L
|
1340 |
L
|
H
|
Y
|
K
|
V
|
N
|
P
|
E
|
F
|
N
|
1350 |
M
|
N
|
P
|
P
|
V
|
M
|
D
|
Q
|
F
|
N
|
1360 |
M
|
N
|
L
|
E
|
Q
|
H
|
L
|
A
|
P
|
Q
|
1370 |
E
|
H
|
M
|
Q
|
N
|
L
|
P
|
F
|
E
|
P
|
1380 |
R
|
T
|
A
|
V
|
K
|
N
|
F
|
M
|
A
|
S
|
1390 |
E
|
L
|
D
|
D
|
N
|
A
|
G
|
L
|
S
|
R
|
1400 |
S
|
E
|
T
|
G
|
S
|
T
|
I
|
S
|
M
|
S
|
1410 |
S
|
L
|
E
|
R
|
R
|
K
|
S
|
R
|
Y
|
S
|
1420 |
D
|
L
|
D
|
F
|
E
|
K
|
V
|
M
|
H
|
T
|
1430 |
R
|
K
|
R
|
H
|
M
|
E
|
L
|
F
|
Q
|
E
|
1440 |
L
|
N
|
Q
|
K
|
F
|
Q
|
T
|
L
|
D
|
R
|
1450 |
F
|
R
|
D
|
I
|
P
|
N
|
T
|
S
|
S
|
M
|
1460 |
E
|
N
|
P
|
A
|
P
|
N
|
K
|
N
|
P
|
W
|
1470 |
D
|
T
|
F
|
K
|
N
|
P
|
S
|
E
|
Y
|
P
|
1480 |
H
|
Y
|
T
|
T
|
I
|
N
|
V
|
L
|
D
|
T
|
1490 |
E
|
A
|
K
|
D
|
A
|
L
|
E
|
L
|
R
|
P
|
1500 |
A
|
E
|
W
|
E
|
K
|
C
|
L
|
N
|
L
|
P
|
1510 |
L
|
D
|
V
|
Q
|
E
|
G
|
D
|
F
|
Q
|
T
|
1520 |
E
|
V
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available