ADGRD2 (agrd2_human)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRD ADGRD2
GENE
ADGRD2 (GPR144, PGR24)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adhesion G-protein coupled receptor D2, G-protein coupled receptor 144, G-protein coupled receptor PGR24
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
A
|
P
|
W
|
G
|
A
|
G
|
E
|
R
|
10 |
W
|
L
|
H
|
G
|
A
|
A
|
V
|
D
|
R
|
S
|
20 |
G
|
V
|
S
|
L
|
G
|
P
|
P
|
P
|
T
|
P
|
30 |
Q
|
V
|
N
|
Q
|
G
|
T
|
L
|
G
|
P
|
Q
|
40 |
V
|
A
|
P
|
V
|
A
|
A
|
G
|
E
|
V
|
V
|
50 |
K
|
T
|
A
|
G
|
G
|
V
|
C
|
K
|
F
|
S
|
60 |
G
|
Q
|
R
|
L
|
S
|
W
|
W
|
Q
|
A
|
Q
|
70 |
E
|
S
|
C
|
E
|
Q
|
Q
|
F
|
G
|
H
|
L
|
80 |
A
|
L
|
Q
|
P
|
P
|
D
|
G
|
V
|
L
|
A
|
90 |
S
|
R
|
L
|
R
|
D
|
P
|
V
|
W
|
V
|
G
|
100 |
Q
|
R
|
E
|
A
|
P
|
L
|
R
|
R
|
P
|
P
|
110 |
Q
|
R
|
R
|
A
|
R
|
T
|
T
|
A
|
V
|
L
|
120 |
V
|
F
|
D
|
E
|
R
|
T
|
A
|
D
|
R
|
A
|
130 |
A
|
R
|
L
|
R
|
S
|
P
|
L
|
P
|
E
|
L
|
140 |
A
|
A
|
L
|
T
|
A
|
C
|
T
|
H
|
V
|
Q
|
150 |
W
|
D
|
C
|
A
|
S
|
P
|
D
|
P
|
A
|
A
|
160 |
L
|
F
|
S
|
V
|
A
|
A
|
P
|
A
|
L
|
P
|
170 |
N
|
A
|
L
|
Q
|
L
|
R
|
A
|
F
|
A
|
E
|
180 |
P
|
G
|
G
|
V
|
V
|
R
|
A
|
A
|
L
|
V
|
190 |
V
|
R
|
G
|
Q
|
H
|
A
|
P
|
F
|
L
|
A
|
200 |
A
|
F
|
R
|
A
|
D
|
G
|
R
|
W
|
H
|
H
|
210 |
V
|
C
|
A
|
T
|
W
|
E
|
Q
|
R
|
G
|
G
|
220 |
R
|
W
|
A
|
L
|
F
|
S
|
D
|
G
|
R
|
R
|
230 |
R
|
A
|
G
|
A
|
R
|
G
|
L
|
G
|
A
|
G
|
240 |
H
|
P
|
V
|
P
|
S
|
G
|
G
|
I
|
L
|
V
|
250 |
L
|
G
|
Q
|
D
|
Q
|
D
|
S
|
L
|
G
|
G
|
260 |
G
|
F
|
S
|
V
|
R
|
H
|
A
|
L
|
S
|
G
|
270 |
N
|
L
|
T
|
D
|
F
|
H
|
L
|
W
|
A
|
R
|
280 |
A
|
L
|
S
|
P
|
A
|
Q
|
L
|
H
|
R
|
A
|
290 |
R
|
A
|
C
|
A
|
P
|
P
|
S
|
E
|
G
|
L
|
300 |
L
|
F
|
R
|
W
|
D
|
P
|
G
|
A
|
L
|
D
|
310 |
V
|
T
|
P
|
S
|
L
|
L
|
P
|
T
|
V
|
W
|
320 |
V
|
R
|
L
|
L
|
C
|
P
|
V
|
P
|
S
|
E
|
330 |
E
|
C
|
P
|
T
|
W
|
N
|
P
|
G
|
P
|
R
|
340 |
S
|
E
|
G
|
S
|
E
|
L
|
C
|
L
|
E
|
P
|
350 |
Q
|
P
|
F
|
L
|
C
|
C
|
Y
|
R
|
T
|
E
|
360 |
P
|
Y
|
R
|
R
|
L
|
Q
|
D
|
A
|
Q
|
S
|
370 |
W
|
P
|
G
|
Q
|
D
|
V
|
I
|
S
|
R
|
V
|
380 |
N
|
A
|
L
|
A
|
N
|
D
|
I
|
V
|
L
|
L
|
390 |
P
|
D
|
P
|
L
|
S
|
E
|
V
|
H
|
G
|
A
|
400 |
L
|
S
|
P
|
A
|
E
|
A
|
S
|
S
|
F
|
L
|
410 |
G
|
L
|
L
|
E
|
H
|
V
|
L
|
A
|
M
|
E
|
420 |
M
|
A
|
P
|
L
|
G
|
P
|
A
|
A
|
L
|
L
|
430 |
A
|
V
|
V
|
R
|
F
|
L
|
K
|
R
|
V
|
V
|
440 |
A
|
L
|
G
|
A
|
G
|
D
|
P
|
E
|
L
|
L
|
450 |
L
|
T
|
G
|
P
|
W
|
E
|
Q
|
L
|
S
|
Q
|
460 |
G
|
V
|
V
|
S
|
V
|
A
|
S
|
L
|
V
|
L
|
470 |
E
|
E
|
Q
|
V
|
A
|
D
|
T
|
W
|
L
|
S
|
480 |
L
|
R
|
E
|
V
|
I
|
G
|
G
|
P
|
M
|
A
|
490 |
L
|
V
|
A
|
S
|
V
|
Q
|
R
|
L
|
A
|
P
|
500 |
L
|
L
|
S
|
T
|
S
|
M
|
T
|
S
|
E
|
R
|
510 |
P
|
R
|
M
|
R
|
I
|
Q
|
H
|
R
|
H
|
A
|
520 |
G
|
L
|
S
|
G
|
V
|
T
|
V
|
I
|
H
|
S
|
530 |
W
|
F
|
T
|
S
|
R
|
V
|
F
|
Q
|
H
|
T
|
540 |
L
|
E
|
G
|
P
|
D
|
L
|
E
|
P
|
Q
|
A
|
550 |
P
|
A
|
S
|
S
|
E
|
E
|
A
|
N
|
R
|
V
|
560 |
Q
|
R
|
F
|
L
|
S
|
T
|
Q
|
V
|
G
|
S
|
570 |
A
|
I
|
I
|
S
|
S
|
E
|
V
|
W
|
D
|
V
|
580 |
T
|
G
|
E
|
V
|
N
|
V
|
A
|
M
|
T
|
F
|
590 |
H
|
L
|
Q
|
H
|
R
|
A
|
Q
|
S
|
P
|
L
|
600 |
F
|
P
|
P
|
H
|
P
|
P
|
S
|
P
|
Y
|
T
|
610 |
G
|
G
|
A
|
W
|
A
|
T
|
T
|
G
|
C
|
S
|
620 |
V
|
A
|
A
|
L
|
Y
|
L
|
D
|
S
|
T
|
A
|
630 |
C
|
F
|
C
|
N
|
H
|
S
|
T
|
S
|
F
|
A
|
640 |
I
|
L
|
L
|
Q
|
I
|
Y
|
E
|
V
|
Q
|
R
|
650 |
TM1 | |||||||||
G
|
P
|
E
|
E
|
E
|
S
|
L
|
L
|
R
|
T
|
660 |
L
|
S
|
F
|
V
|
G
|
C
|
G
|
V
|
S
|
F
|
670 |
C
|
A
|
L
|
T
|
T
|
T
|
F
|
L
|
L
|
F
|
680 |
ICL1 | TM2 | |||||||||||
L
|
V
|
A
|
G
|
V
|
P
|
K
|
S
|
E
|
R
|
|||
690 |
T
|
T
|
V
|
H
|
K
|
N
|
L
|
T
|
F
|
S
|
700 |
L
|
A
|
S
|
A
|
E
|
G
|
F
|
L
|
M
|
T
|
710 |
ECL1 | |||||||||
S
|
E
|
W
|
A
|
K
|
A
|
N
|
E
|
V
|
A
|
720 |
TM3 | |||||||||
C
|
V
|
A
|
V
|
T
|
V
|
A
|
M
|
H
|
F
|
730 |
L
|
F
|
L
|
V
|
A
|
F
|
S
|
W
|
M
|
L
|
740 |
V
|
E
|
G
|
L
|
L
|
L
|
W
|
R
|
K
|
V
|
750 |
ICL2 | |||||||||
V
|
A
|
V
|
S
|
M
|
H
|
P
|
G
|
P
|
G
|
760 |
TM4 | |||||||||
M
|
R
|
L
|
Y
|
H
|
A
|
T
|
G
|
W
|
G
|
770 |
V
|
P
|
V
|
G
|
I
|
V
|
A
|
V
|
T
|
L
|
780 |
ECL2 | |||||||||
A
|
M
|
L
|
P
|
H
|
D
|
Y
|
V
|
A
|
P
|
790 |
G
|
H
|
C
|
W
|
L
|
N
|
V
|
H
|
T
|
N
|
800 |
TM5 | |||||||||
A
|
I
|
W
|
A
|
F
|
V
|
G
|
P
|
V
|
L
|
810 |
F
|
V
|
L
|
T
|
A
|
N
|
T
|
C
|
I
|
L
|
820 |
A
|
R
|
V
|
V
|
M
|
I
|
T
|
V
|
S
|
S
|
830 |
ICL3 | |||||||||
A
|
R
|
R
|
R
|
A
|
R
|
M
|
L
|
S
|
P
|
840 |
Q
|
P
|
C
|
L
|
Q
|
Q
|
Q
|
I
|
W
|
T
|
850 |
TM6 | |||||||||
Q
|
I
|
W
|
A
|
T
|
V
|
K
|
P
|
V
|
L
|
860 |
V
|
L
|
L
|
P
|
V
|
L
|
G
|
L
|
T
|
W
|
870 |
L
|
A
|
G
|
I
|
L
|
V
|
H
|
L
|
S
|
P
|
880 |
TM7 | |||||||||
A
|
W
|
A
|
Y
|
A
|
A
|
V
|
G
|
L
|
N
|
890 |
S
|
I
|
Q
|
G
|
L
|
Y
|
I
|
F
|
L
|
V
|
900 |
H8 | |||||||||
Y
|
A
|
A
|
C
|
N
|
E
|
E
|
V
|
R
|
S
|
910 |
A
|
L
|
Q
|
R
|
M
|
A
|
E
|
K
|
K
|
V
|
920 |
C-term | |||||||||
A
|
E
|
V
|
L
|
R
|
A
|
L
|
G
|
V
|
W
|
930 |
G
|
G
|
A
|
A
|
K
|
E
|
H
|
S
|
L
|
P
|
940 |
F
|
S
|
V
|
L
|
P
|
L
|
F
|
L
|
P
|
P
|
950 |
K
|
P
|
S
|
T
|
P
|
R
|
H
|
P
|
L
|
K
|
960 |
A
|
P
|
A
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available