ADGRE4P (agre4_human)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRE ADGRE4P
GENE
ADGRE4P (EMR4, EMR4P, GPR127, PGR16)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Putative adhesion G protein-coupled receptor E4P, EGF-like module receptor 4, EGF-like module-containing mucin-like hormone receptor-like 4, G-protein coupled receptor 127, G-protein coupled receptor PGR16
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
S
|
R
|
F
|
L
|
L
|
V
|
L
|
L
|
10 |
S
|
G
|
A
|
S
|
C
|
P
|
P
|
C
|
P
|
K
|
20 |
Y
|
A
|
S
|
C
|
H
|
N
|
S
|
T
|
H
|
C
|
30 |
T
|
C
|
E
|
D
|
G
|
F
|
R
|
A
|
R
|
S
|
40 |
G
|
R
|
T
|
Y
|
F
|
H
|
D
|
S
|
S
|
E
|
50 |
K
|
C
|
E
|
D
|
I
|
N
|
E
|
C
|
E
|
T
|
60 |
G
|
L
|
A
|
K
|
C
|
K
|
Y
|
K
|
A
|
Y
|
70 |
C
|
R
|
N
|
K
|
V
|
G
|
G
|
Y
|
I
|
C
|
80 |
S
|
C
|
L
|
V
|
K
|
Y
|
T
|
L
|
F
|
N
|
90 |
F
|
L
|
A
|
G
|
I
|
I
|
D
|
Y
|
D
|
H
|
100 |
P
|
D
|
C
|
Y
|
E
|
N
|
N
|
S
|
Q
|
G
|
110 |
T
|
T
|
Q
|
S
|
N
|
V
|
D
|
I
|
W
|
V
|
120 |
S
|
G
|
V
|
K
|
P
|
G
|
F
|
G
|
K
|
Q
|
130 |
L
|
P
|
G
|
D
|
K
|
R
|
T
|
K
|
H
|
I
|
140 |
C
|
V
|
Y
|
W
|
E
|
G
|
S
|
E
|
G
|
G
|
150 |
W
|
S
|
T
|
E
|
G
|
C
|
S
|
H
|
V
|
H
|
160 |
S
|
N
|
G
|
S
|
Y
|
T
|
K
|
C
|
K
|
C
|
170 |
F
|
H
|
L
|
S
|
S
|
F
|
A
|
V
|
L
|
V
|
180 |
TM1 | |||||||||
A
|
L
|
A
|
P
|
K
|
E
|
D
|
P
|
V
|
L
|
190 |
T
|
V
|
I
|
T
|
Q
|
V
|
G
|
L
|
T
|
I
|
200 |
S
|
L
|
L
|
C
|
L
|
F
|
L
|
A
|
I
|
L
|
210 |
ICL1 | |||||||||
T
|
F
|
L
|
L
|
C
|
R
|
P
|
I
|
Q
|
N
|
220 |
TM2 | |||||||||
T
|
S
|
T
|
S
|
L
|
H
|
L
|
E
|
L
|
S
|
230 |
L
|
C
|
L
|
F
|
L
|
A
|
H
|
L
|
L
|
F
|
240 |
ECL1 | |||||||||
L
|
T
|
G
|
I
|
N
|
R
|
T
|
E
|
P
|
E
|
250 |
TM3 | |||||||||
V
|
L
|
C
|
S
|
I
|
I
|
A
|
G
|
L
|
L
|
260 |
H
|
F
|
L
|
Y
|
L
|
A
|
C
|
F
|
T
|
W
|
270 |
M
|
L
|
L
|
E
|
G
|
L
|
H
|
L
|
F
|
L
|
280 |
ICL2 | |||||||||
T
|
V
|
R
|
N
|
L
|
K
|
V
|
A
|
N
|
Y
|
290 |
TM4 | |||||||||
T
|
S
|
T
|
G
|
R
|
F
|
K
|
K
|
R
|
F
|
300 |
M
|
Y
|
P
|
V
|
G
|
Y
|
G
|
I
|
P
|
A
|
310 |
V
|
I
|
I
|
A
|
V
|
S
|
A
|
I
|
V
|
G
|
320 |
ECL2 | |||||||||
P
|
Q
|
N
|
Y
|
G
|
T
|
F
|
T
|
C
|
W
|
330 |
TM5 | |||||||||
L
|
K
|
L
|
D
|
K
|
G
|
F
|
I
|
W
|
S
|
340 |
F
|
M
|
G
|
P
|
V
|
A
|
V
|
I
|
I
|
L
|
350 |
I
|
N
|
L
|
V
|
F
|
Y
|
F
|
Q
|
V
|
L
|
360 |
W
|
I
|
L
|
R
|
S
|
K
|
L
|
S
|
S
|
L
|
370 |
ICL3 | |||||||||
N
|
K
|
E
|
V
|
S
|
T
|
I
|
Q
|
D
|
T
|
380 |
TM6 | |||||||||
R
|
V
|
M
|
T
|
F
|
K
|
A
|
I
|
S
|
Q
|
390 |
L
|
F
|
I
|
L
|
G
|
C
|
S
|
W
|
G
|
L
|
400 |
ECL3 | |||||||||
G
|
F
|
F
|
M
|
V
|
E
|
E
|
V
|
G
|
K
|
410 |
TM7 | |||||||||
T
|
I
|
G
|
S
|
I
|
I
|
A
|
Y
|
S
|
F
|
420 |
T
|
I
|
I
|
N
|
T
|
L
|
Q
|
G
|
V
|
L
|
430 |
H8 | |||||||||
L
|
F
|
V
|
V
|
H
|
C
|
L
|
L
|
N
|
R
|
440 |
Q
|
V
|
R
|
L
|
I
|
I
|
L
|
S
|
V
|
I
|
450 |
S
|
L
|
V
|
P
|
K
|
S
|
N
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
STRUCTURES
No structures available