ADGRV1 (agrv1_human)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRV ADGRV1
GENE
ADGRV1 (GPR98, KIAA0686, KIAA1943, MASS1, VLGR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adhesion G-protein coupled receptor V1, ADGRV1, 3.4.-.-, G-protein coupled receptor 98, Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1, ADGRV1 subunit alpha, ADGRV1 subunit beta
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
V
|
F
|
L
|
G
|
P
|
G
|
M
|
P
|
10 |
S
|
A
|
S
|
L
|
L
|
V
|
N
|
L
|
L
|
S
|
20 |
A
|
L
|
L
|
I
|
L
|
F
|
V
|
F
|
G
|
E
|
30 |
T
|
E
|
I
|
R
|
F
|
T
|
G
|
Q
|
T
|
E
|
40 |
F
|
V
|
V
|
N
|
E
|
T
|
S
|
T
|
T
|
V
|
50 |
I
|
R
|
L
|
I
|
I
|
E
|
R
|
I
|
G
|
E
|
60 |
P
|
A
|
N
|
V
|
T
|
A
|
I
|
V
|
S
|
L
|
70 |
Y
|
G
|
E
|
D
|
A
|
G
|
D
|
F
|
F
|
D
|
80 |
T
|
Y
|
A
|
A
|
A
|
F
|
I
|
P
|
A
|
G
|
90 |
E
|
T
|
N
|
R
|
T
|
V
|
Y
|
I
|
A
|
V
|
100 |
C
|
D
|
D
|
D
|
L
|
P
|
E
|
P
|
D
|
E
|
110 |
T
|
F
|
I
|
F
|
H
|
L
|
T
|
L
|
Q
|
K
|
120 |
P
|
S
|
A
|
N
|
V
|
K
|
L
|
G
|
W
|
P
|
130 |
R
|
T
|
V
|
T
|
V
|
T
|
I
|
L
|
S
|
N
|
140 |
D
|
N
|
A
|
F
|
G
|
I
|
I
|
S
|
F
|
N
|
150 |
M
|
L
|
P
|
S
|
I
|
A
|
V
|
S
|
E
|
P
|
160 |
K
|
G
|
R
|
N
|
E
|
S
|
M
|
P
|
L
|
T
|
170 |
L
|
I
|
R
|
E
|
K
|
G
|
T
|
Y
|
G
|
M
|
180 |
V
|
M
|
V
|
T
|
F
|
E
|
V
|
E
|
G
|
G
|
190 |
P
|
N
|
P
|
P
|
D
|
E
|
D
|
L
|
S
|
P
|
200 |
V
|
K
|
G
|
N
|
I
|
T
|
F
|
P
|
P
|
G
|
210 |
R
|
A
|
T
|
V
|
I
|
Y
|
N
|
L
|
T
|
V
|
220 |
L
|
D
|
D
|
E
|
V
|
P
|
E
|
N
|
D
|
E
|
230 |
I
|
F
|
L
|
I
|
Q
|
L
|
K
|
S
|
V
|
E
|
240 |
G
|
G
|
A
|
E
|
I
|
N
|
T
|
S
|
R
|
N
|
250 |
S
|
I
|
E
|
I
|
I
|
I
|
K
|
K
|
N
|
D
|
260 |
S
|
P
|
V
|
R
|
F
|
L
|
Q
|
S
|
I
|
Y
|
270 |
L
|
V
|
P
|
E
|
E
|
D
|
H
|
I
|
L
|
I
|
280 |
I
|
P
|
V
|
V
|
R
|
G
|
K
|
D
|
N
|
N
|
290 |
G
|
N
|
L
|
I
|
G
|
S
|
D
|
E
|
Y
|
E
|
300 |
V
|
S
|
I
|
S
|
Y
|
A
|
V
|
T
|
T
|
G
|
310 |
N
|
S
|
T
|
A
|
H
|
A
|
Q
|
Q
|
N
|
L
|
320 |
D
|
F
|
I
|
D
|
L
|
Q
|
P
|
N
|
T
|
T
|
330 |
V
|
V
|
F
|
P
|
P
|
F
|
I
|
H
|
E
|
S
|
340 |
H
|
L
|
K
|
F
|
Q
|
I
|
V
|
D
|
D
|
T
|
350 |
I
|
P
|
E
|
I
|
A
|
E
|
S
|
F
|
H
|
I
|
360 |
M
|
L
|
L
|
K
|
D
|
T
|
L
|
Q
|
G
|
D
|
370 |
A
|
V
|
L
|
I
|
S
|
P
|
S
|
V
|
V
|
Q
|
380 |
V
|
T
|
I
|
K
|
P
|
N
|
D
|
K
|
P
|
Y
|
390 |
G
|
V
|
L
|
S
|
F
|
N
|
S
|
V
|
L
|
F
|
400 |
E
|
R
|
T
|
V
|
I
|
I
|
D
|
E
|
D
|
R
|
410 |
I
|
S
|
R
|
Y
|
E
|
E
|
I
|
T
|
V
|
V
|
420 |
R
|
N
|
G
|
G
|
T
|
H
|
G
|
N
|
V
|
S
|
430 |
A
|
N
|
W
|
V
|
L
|
T
|
R
|
N
|
S
|
T
|
440 |
D
|
P
|
S
|
P
|
V
|
T
|
A
|
D
|
I
|
R
|
450 |
P
|
S
|
S
|
G
|
V
|
L
|
H
|
F
|
A
|
Q
|
460 |
G
|
Q
|
M
|
L
|
A
|
T
|
I
|
P
|
L
|
T
|
470 |
V
|
V
|
D
|
D
|
D
|
L
|
P
|
E
|
E
|
A
|
480 |
E
|
A
|
Y
|
L
|
L
|
Q
|
I
|
L
|
P
|
H
|
490 |
T
|
I
|
R
|
G
|
G
|
A
|
E
|
V
|
S
|
E
|
500 |
P
|
A
|
E
|
L
|
L
|
F
|
Y
|
I
|
Q
|
D
|
510 |
S
|
D
|
D
|
V
|
Y
|
G
|
L
|
I
|
T
|
F
|
520 |
F
|
P
|
M
|
E
|
N
|
Q
|
K
|
I
|
E
|
S
|
530 |
S
|
P
|
G
|
E
|
R
|
Y
|
L
|
S
|
L
|
S
|
540 |
F
|
T
|
R
|
L
|
G
|
G
|
T
|
K
|
G
|
D
|
550 |
V
|
R
|
L
|
L
|
Y
|
S
|
V
|
L
|
Y
|
I
|
560 |
P
|
A
|
G
|
A
|
V
|
D
|
P
|
L
|
Q
|
A
|
570 |
K
|
E
|
G
|
I
|
L
|
N
|
I
|
S
|
R
|
R
|
580 |
N
|
D
|
L
|
I
|
F
|
P
|
E
|
Q
|
K
|
T
|
590 |
Q
|
V
|
T
|
T
|
K
|
L
|
P
|
I
|
R
|
N
|
600 |
D
|
A
|
F
|
L
|
Q
|
N
|
G
|
A
|
H
|
F
|
610 |
L
|
V
|
Q
|
L
|
E
|
T
|
V
|
E
|
L
|
L
|
620 |
N
|
I
|
I
|
P
|
L
|
I
|
P
|
P
|
I
|
S
|
630 |
P
|
R
|
F
|
G
|
E
|
I
|
C
|
N
|
I
|
S
|
640 |
L
|
L
|
V
|
T
|
P
|
A
|
I
|
A
|
N
|
G
|
650 |
E
|
I
|
G
|
F
|
L
|
S
|
N
|
L
|
P
|
I
|
660 |
I
|
L
|
H
|
E
|
P
|
E
|
D
|
F
|
A
|
A
|
670 |
E
|
V
|
V
|
Y
|
I
|
P
|
L
|
H
|
R
|
D
|
680 |
G
|
T
|
D
|
G
|
Q
|
A
|
T
|
V
|
Y
|
W
|
690 |
S
|
L
|
K
|
P
|
S
|
G
|
F
|
N
|
S
|
K
|
700 |
A
|
V
|
T
|
P
|
D
|
D
|
I
|
G
|
P
|
F
|
710 |
N
|
G
|
S
|
V
|
L
|
F
|
L
|
S
|
G
|
Q
|
720 |
S
|
D
|
T
|
T
|
I
|
N
|
I
|
T
|
I
|
K
|
730 |
G
|
D
|
D
|
I
|
P
|
E
|
M
|
N
|
E
|
T
|
740 |
V
|
T
|
L
|
S
|
L
|
D
|
R
|
V
|
N
|
V
|
750 |
E
|
N
|
Q
|
V
|
L
|
K
|
S
|
G
|
Y
|
T
|
760 |
S
|
R
|
D
|
L
|
I
|
I
|
L
|
E
|
N
|
D
|
770 |
D
|
P
|
G
|
G
|
V
|
F
|
E
|
F
|
S
|
P
|
780 |
A
|
S
|
R
|
G
|
P
|
Y
|
V
|
I
|
K
|
E
|
790 |
G
|
E
|
S
|
V
|
E
|
L
|
H
|
I
|
I
|
R
|
800 |
S
|
R
|
G
|
S
|
L
|
V
|
K
|
Q
|
F
|
L
|
810 |
H
|
Y
|
R
|
V
|
E
|
P
|
R
|
D
|
S
|
N
|
820 |
E
|
F
|
Y
|
G
|
N
|
T
|
G
|
V
|
L
|
E
|
830 |
F
|
K
|
P
|
G
|
E
|
R
|
E
|
I
|
V
|
I
|
840 |
T
|
L
|
L
|
A
|
R
|
L
|
D
|
G
|
I
|
P
|
850 |
E
|
L
|
D
|
E
|
H
|
Y
|
W
|
V
|
V
|
L
|
860 |
S
|
S
|
H
|
G
|
E
|
R
|
E
|
S
|
K
|
L
|
870 |
G
|
S
|
A
|
T
|
I
|
V
|
N
|
I
|
T
|
I
|
880 |
L
|
K
|
N
|
D
|
D
|
P
|
H
|
G
|
I
|
I
|
890 |
E
|
F
|
V
|
S
|
D
|
G
|
L
|
I
|
V
|
M
|
900 |
I
|
N
|
E
|
S
|
K
|
G
|
D
|
A
|
I
|
Y
|
910 |
S
|
A
|
V
|
Y
|
D
|
V
|
V
|
R
|
N
|
R
|
920 |
G
|
N
|
F
|
G
|
D
|
V
|
S
|
V
|
S
|
W
|
930 |
V
|
V
|
S
|
P
|
D
|
F
|
T
|
Q
|
D
|
V
|
940 |
F
|
P
|
V
|
Q
|
G
|
T
|
V
|
V
|
F
|
G
|
950 |
D
|
Q
|
E
|
F
|
S
|
K
|
N
|
I
|
T
|
I
|
960 |
Y
|
S
|
L
|
P
|
D
|
E
|
I
|
P
|
E
|
E
|
970 |
M
|
E
|
E
|
F
|
T
|
V
|
I
|
L
|
L
|
N
|
980 |
G
|
T
|
G
|
G
|
A
|
K
|
V
|
G
|
N
|
R
|
990 |
T
|
T
|
A
|
T
|
L
|
R
|
I
|
R
|
R
|
N
|
1000 |
D
|
D
|
P
|
I
|
Y
|
F
|
A
|
E
|
P
|
R
|
1010 |
V
|
V
|
R
|
V
|
Q
|
E
|
G
|
E
|
T
|
A
|
1020 |
N
|
F
|
T
|
V
|
L
|
R
|
N
|
G
|
S
|
V
|
1030 |
D
|
V
|
T
|
C
|
M
|
V
|
Q
|
Y
|
A
|
T
|
1040 |
K
|
D
|
G
|
K
|
A
|
T
|
A
|
R
|
E
|
R
|
1050 |
D
|
F
|
I
|
P
|
V
|
E
|
K
|
G
|
E
|
T
|
1060 |
L
|
I
|
F
|
E
|
V
|
G
|
S
|
R
|
Q
|
Q
|
1070 |
S
|
I
|
S
|
I
|
F
|
V
|
N
|
E
|
D
|
G
|
1080 |
I
|
P
|
E
|
T
|
D
|
E
|
P
|
F
|
Y
|
I
|
1090 |
I
|
L
|
L
|
N
|
S
|
T
|
G
|
D
|
T
|
V
|
1100 |
V
|
Y
|
Q
|
Y
|
G
|
V
|
A
|
T
|
V
|
I
|
1110 |
I
|
E
|
A
|
N
|
D
|
D
|
P
|
N
|
G
|
I
|
1120 |
F
|
S
|
L
|
E
|
P
|
I
|
D
|
K
|
A
|
V
|
1130 |
E
|
E
|
G
|
K
|
T
|
N
|
A
|
F
|
W
|
I
|
1140 |
L
|
R
|
H
|
R
|
G
|
Y
|
F
|
G
|
S
|
V
|
1150 |
S
|
V
|
S
|
W
|
Q
|
L
|
F
|
Q
|
N
|
D
|
1160 |
S
|
A
|
L
|
Q
|
P
|
G
|
Q
|
E
|
F
|
Y
|
1170 |
E
|
T
|
S
|
G
|
T
|
V
|
N
|
F
|
M
|
D
|
1180 |
G
|
E
|
E
|
A
|
K
|
P
|
I
|
I
|
L
|
H
|
1190 |
A
|
F
|
P
|
D
|
K
|
I
|
P
|
E
|
F
|
N
|
1200 |
E
|
F
|
Y
|
F
|
L
|
K
|
L
|
V
|
N
|
I
|
1210 |
S
|
G
|
G
|
S
|
P
|
G
|
P
|
G
|
G
|
Q
|
1220 |
L
|
A
|
E
|
T
|
N
|
L
|
Q
|
V
|
T
|
V
|
1230 |
M
|
V
|
P
|
F
|
N
|
D
|
D
|
P
|
F
|
G
|
1240 |
V
|
F
|
I
|
L
|
D
|
P
|
E
|
C
|
L
|
E
|
1250 |
R
|
E
|
V
|
A
|
E
|
D
|
V
|
L
|
S
|
E
|
1260 |
D
|
D
|
M
|
S
|
Y
|
I
|
T
|
N
|
F
|
T
|
1270 |
I
|
L
|
R
|
Q
|
Q
|
G
|
V
|
F
|
G
|
D
|
1280 |
V
|
Q
|
L
|
G
|
W
|
E
|
I
|
L
|
S
|
S
|
1290 |
E
|
F
|
P
|
A
|
G
|
L
|
P
|
P
|
M
|
I
|
1300 |
D
|
F
|
L
|
L
|
V
|
G
|
I
|
F
|
P
|
T
|
1310 |
T
|
V
|
H
|
L
|
Q
|
Q
|
H
|
M
|
R
|
R
|
1320 |
H
|
H
|
S
|
G
|
T
|
D
|
A
|
L
|
Y
|
F
|
1330 |
T
|
G
|
L
|
E
|
G
|
A
|
F
|
G
|
T
|
V
|
1340 |
N
|
P
|
K
|
Y
|
H
|
P
|
S
|
R
|
N
|
N
|
1350 |
T
|
I
|
A
|
N
|
F
|
T
|
F
|
S
|
A
|
W
|
1360 |
V
|
M
|
P
|
N
|
A
|
N
|
T
|
N
|
G
|
F
|
1370 |
I
|
I
|
A
|
K
|
D
|
D
|
G
|
N
|
G
|
S
|
1380 |
I
|
Y
|
Y
|
G
|
V
|
K
|
I
|
Q
|
T
|
N
|
1390 |
E
|
S
|
H
|
V
|
T
|
L
|
S
|
L
|
H
|
Y
|
1400 |
K
|
T
|
L
|
G
|
S
|
N
|
A
|
T
|
Y
|
I
|
1410 |
A
|
K
|
T
|
T
|
V
|
M
|
K
|
Y
|
L
|
E
|
1420 |
E
|
S
|
V
|
W
|
L
|
H
|
L
|
L
|
I
|
I
|
1430 |
L
|
E
|
D
|
G
|
I
|
I
|
E
|
F
|
Y
|
L
|
1440 |
D
|
G
|
N
|
A
|
M
|
P
|
R
|
G
|
I
|
K
|
1450 |
S
|
L
|
K
|
G
|
E
|
A
|
I
|
T
|
D
|
G
|
1460 |
P
|
G
|
I
|
L
|
R
|
I
|
G
|
A
|
G
|
I
|
1470 |
N
|
G
|
N
|
D
|
R
|
F
|
T
|
G
|
L
|
M
|
1480 |
Q
|
D
|
V
|
R
|
S
|
Y
|
E
|
R
|
K
|
L
|
1490 |
T
|
L
|
E
|
E
|
I
|
Y
|
E
|
L
|
H
|
A
|
1500 |
M
|
P
|
A
|
K
|
S
|
D
|
L
|
H
|
P
|
I
|
1510 |
S
|
G
|
Y
|
L
|
E
|
F
|
R
|
Q
|
G
|
E
|
1520 |
T
|
N
|
K
|
S
|
F
|
I
|
I
|
S
|
A
|
R
|
1530 |
D
|
D
|
N
|
D
|
E
|
E
|
G
|
E
|
E
|
L
|
1540 |
F
|
I
|
L
|
K
|
L
|
V
|
S
|
V
|
Y
|
G
|
1550 |
G
|
A
|
R
|
I
|
S
|
E
|
E
|
N
|
T
|
T
|
1560 |
A
|
R
|
L
|
T
|
I
|
Q
|
K
|
S
|
D
|
N
|
1570 |
A
|
N
|
G
|
L
|
F
|
G
|
F
|
T
|
G
|
A
|
1580 |
C
|
I
|
P
|
E
|
I
|
A
|
E
|
E
|
G
|
S
|
1590 |
T
|
I
|
S
|
C
|
V
|
V
|
E
|
R
|
T
|
R
|
1600 |
G
|
A
|
L
|
D
|
Y
|
V
|
H
|
V
|
F
|
Y
|
1610 |
T
|
I
|
S
|
Q
|
I
|
E
|
T
|
D
|
G
|
I
|
1620 |
N
|
Y
|
L
|
V
|
D
|
D
|
F
|
A
|
N
|
A
|
1630 |
S
|
G
|
T
|
I
|
T
|
F
|
L
|
P
|
W
|
Q
|
1640 |
R
|
S
|
E
|
V
|
L
|
N
|
I
|
Y
|
V
|
L
|
1650 |
D
|
D
|
D
|
I
|
P
|
E
|
L
|
N
|
E
|
Y
|
1660 |
F
|
R
|
V
|
T
|
L
|
V
|
S
|
A
|
I
|
P
|
1670 |
G
|
D
|
G
|
K
|
L
|
G
|
S
|
T
|
P
|
T
|
1680 |
S
|
G
|
A
|
S
|
I
|
D
|
P
|
E
|
K
|
E
|
1690 |
T
|
T
|
D
|
I
|
T
|
I
|
K
|
A
|
S
|
D
|
1700 |
H
|
P
|
Y
|
G
|
L
|
L
|
Q
|
F
|
S
|
T
|
1710 |
G
|
L
|
P
|
P
|
Q
|
P
|
K
|
D
|
A
|
M
|
1720 |
T
|
L
|
P
|
A
|
S
|
S
|
V
|
P
|
H
|
I
|
1730 |
T
|
V
|
E
|
E
|
E
|
D
|
G
|
E
|
I
|
R
|
1740 |
L
|
L
|
V
|
I
|
R
|
A
|
Q
|
G
|
L
|
L
|
1750 |
G
|
R
|
V
|
T
|
A
|
E
|
F
|
R
|
T
|
V
|
1760 |
S
|
L
|
T
|
A
|
F
|
S
|
P
|
E
|
D
|
Y
|
1770 |
Q
|
N
|
V
|
A
|
G
|
T
|
L
|
E
|
F
|
Q
|
1780 |
P
|
G
|
E
|
R
|
Y
|
K
|
Y
|
I
|
F
|
I
|
1790 |
N
|
I
|
T
|
D
|
N
|
S
|
I
|
P
|
E
|
L
|
1800 |
E
|
K
|
S
|
F
|
K
|
V
|
E
|
L
|
L
|
N
|
1810 |
L
|
E
|
G
|
G
|
V
|
A
|
E
|
L
|
F
|
R
|
1820 |
V
|
D
|
G
|
S
|
G
|
S
|
G
|
D
|
G
|
D
|
1830 |
M
|
E
|
F
|
F
|
L
|
P
|
T
|
I
|
H
|
K
|
1840 |
R
|
A
|
S
|
L
|
G
|
V
|
A
|
S
|
Q
|
I
|
1850 |
L
|
V
|
T
|
I
|
A
|
A
|
S
|
D
|
H
|
A
|
1860 |
H
|
G
|
V
|
F
|
E
|
F
|
S
|
P
|
E
|
S
|
1870 |
L
|
F
|
V
|
S
|
G
|
T
|
E
|
P
|
E
|
D
|
1880 |
G
|
Y
|
S
|
T
|
V
|
T
|
L
|
N
|
V
|
I
|
1890 |
R
|
H
|
H
|
G
|
T
|
L
|
S
|
P
|
V
|
T
|
1900 |
L
|
H
|
W
|
N
|
I
|
D
|
S
|
D
|
P
|
D
|
1910 |
G
|
D
|
L
|
A
|
F
|
T
|
S
|
G
|
N
|
I
|
1920 |
T
|
F
|
E
|
I
|
G
|
Q
|
T
|
S
|
A
|
N
|
1930 |
I
|
T
|
V
|
E
|
I
|
L
|
P
|
D
|
E
|
D
|
1940 |
P
|
E
|
L
|
D
|
K
|
A
|
F
|
S
|
V
|
S
|
1950 |
V
|
L
|
S
|
V
|
S
|
S
|
G
|
S
|
L
|
G
|
1960 |
A
|
H
|
I
|
N
|
A
|
T
|
L
|
T
|
V
|
L
|
1970 |
A
|
S
|
D
|
D
|
P
|
Y
|
G
|
I
|
F
|
I
|
1980 |
F
|
S
|
E
|
K
|
N
|
R
|
P
|
V
|
K
|
V
|
1990 |
E
|
E
|
A
|
T
|
Q
|
N
|
I
|
T
|
L
|
S
|
2000 |
I
|
I
|
R
|
L
|
K
|
G
|
L
|
M
|
G
|
K
|
2010 |
V
|
L
|
V
|
S
|
Y
|
A
|
T
|
L
|
D
|
D
|
2020 |
M
|
E
|
K
|
P
|
P
|
Y
|
F
|
P
|
P
|
N
|
2030 |
L
|
A
|
R
|
A
|
T
|
Q
|
G
|
R
|
D
|
Y
|
2040 |
I
|
P
|
A
|
S
|
G
|
F
|
A
|
L
|
F
|
G
|
2050 |
A
|
N
|
Q
|
S
|
E
|
A
|
T
|
I
|
A
|
I
|
2060 |
S
|
I
|
L
|
D
|
D
|
D
|
E
|
P
|
E
|
R
|
2070 |
S
|
E
|
S
|
V
|
F
|
I
|
E
|
L
|
L
|
N
|
2080 |
S
|
T
|
L
|
V
|
A
|
K
|
V
|
Q
|
S
|
R
|
2090 |
S
|
I
|
P
|
N
|
S
|
P
|
R
|
L
|
G
|
P
|
2100 |
K
|
V
|
E
|
T
|
I
|
A
|
Q
|
L
|
I
|
I
|
2110 |
I
|
A
|
N
|
D
|
D
|
A
|
F
|
G
|
T
|
L
|
2120 |
Q
|
L
|
S
|
A
|
P
|
I
|
V
|
R
|
V
|
A
|
2130 |
E
|
N
|
H
|
V
|
G
|
P
|
I
|
I
|
N
|
V
|
2140 |
T
|
R
|
T
|
G
|
G
|
A
|
F
|
A
|
D
|
V
|
2150 |
S
|
V
|
K
|
F
|
K
|
A
|
V
|
P
|
I
|
T
|
2160 |
A
|
I
|
A
|
G
|
E
|
D
|
Y
|
S
|
I
|
A
|
2170 |
S
|
S
|
D
|
V
|
V
|
L
|
L
|
E
|
G
|
E
|
2180 |
T
|
S
|
K
|
A
|
V
|
P
|
I
|
Y
|
V
|
I
|
2190 |
N
|
D
|
I
|
Y
|
P
|
E
|
L
|
E
|
E
|
S
|
2200 |
F
|
L
|
V
|
Q
|
L
|
M
|
N
|
E
|
T
|
T
|
2210 |
G
|
G
|
A
|
R
|
L
|
G
|
A
|
L
|
T
|
E
|
2220 |
A
|
V
|
I
|
I
|
I
|
E
|
A
|
S
|
D
|
D
|
2230 |
P
|
Y
|
G
|
L
|
F
|
G
|
F
|
Q
|
I
|
T
|
2240 |
K
|
L
|
I
|
V
|
E
|
E
|
P
|
E
|
F
|
N
|
2250 |
S
|
V
|
K
|
V
|
N
|
L
|
P
|
I
|
I
|
R
|
2260 |
N
|
S
|
G
|
T
|
L
|
G
|
N
|
V
|
T
|
V
|
2270 |
Q
|
W
|
V
|
A
|
T
|
I
|
N
|
G
|
Q
|
L
|
2280 |
A
|
T
|
G
|
D
|
L
|
R
|
V
|
V
|
S
|
G
|
2290 |
N
|
V
|
T
|
F
|
A
|
P
|
G
|
E
|
T
|
I
|
2300 |
Q
|
T
|
L
|
L
|
L
|
E
|
V
|
L
|
A
|
D
|
2310 |
D
|
V
|
P
|
E
|
I
|
E
|
E
|
V
|
I
|
Q
|
2320 |
V
|
Q
|
L
|
T
|
D
|
A
|
S
|
G
|
G
|
G
|
2330 |
T
|
I
|
G
|
L
|
D
|
R
|
I
|
A
|
N
|
I
|
2340 |
I
|
I
|
P
|
A
|
N
|
D
|
D
|
P
|
Y
|
G
|
2350 |
T
|
V
|
A
|
F
|
A
|
Q
|
M
|
V
|
Y
|
R
|
2360 |
V
|
Q
|
E
|
P
|
L
|
E
|
R
|
S
|
S
|
C
|
2370 |
A
|
N
|
I
|
T
|
V
|
R
|
R
|
S
|
G
|
G
|
2380 |
H
|
F
|
G
|
R
|
L
|
L
|
L
|
F
|
Y
|
S
|
2390 |
T
|
S
|
D
|
I
|
D
|
V
|
V
|
A
|
L
|
A
|
2400 |
M
|
E
|
E
|
G
|
Q
|
D
|
L
|
L
|
S
|
Y
|
2410 |
Y
|
E
|
S
|
P
|
I
|
Q
|
G
|
V
|
P
|
D
|
2420 |
P
|
L
|
W
|
R
|
T
|
W
|
M
|
N
|
V
|
S
|
2430 |
A
|
V
|
G
|
E
|
P
|
L
|
Y
|
T
|
C
|
A
|
2440 |
T
|
L
|
C
|
L
|
K
|
E
|
Q
|
A
|
C
|
S
|
2450 |
A
|
F
|
S
|
F
|
F
|
S
|
A
|
S
|
E
|
G
|
2460 |
P
|
Q
|
C
|
F
|
W
|
M
|
T
|
S
|
W
|
I
|
2470 |
S
|
P
|
A
|
V
|
N
|
N
|
S
|
D
|
F
|
W
|
2480 |
T
|
Y
|
R
|
K
|
N
|
M
|
T
|
R
|
V
|
A
|
2490 |
S
|
L
|
F
|
S
|
G
|
Q
|
A
|
V
|
A
|
G
|
2500 |
S
|
D
|
Y
|
E
|
P
|
V
|
T
|
R
|
Q
|
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2510 |
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|
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|
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|
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2520 |
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|
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2530 |
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2540 |
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|
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2550 |
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|
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|
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2560 |
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|
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|
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2570 |
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|
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2580 |
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|
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|
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|
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2590 |
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|
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|
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2600 |
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|
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2610 |
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|
2620 |
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|
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2630 |
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2640 |
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2650 |
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|
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2660 |
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2670 |
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2680 |
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|
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D
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2690 |
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|
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|
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|
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|
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|
D
|
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|
2700 |
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2710 |
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2720 |
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2730 |
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|
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2740 |
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2750 |
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2760 |
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2770 |
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2780 |
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|
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|
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2790 |
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|
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|
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|
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|
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|
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|
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2800 |
G
|
I
|
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|
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|
L
|
D
|
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|
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|
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|
Y
|
2810 |
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|
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|
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|
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|
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|
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|
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|
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2820 |
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|
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|
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|
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|
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|
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|
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|
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|
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2830 |
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|
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|
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|
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|
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|
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|
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|
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2840 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
2850 |
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|
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|
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|
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|
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|
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|
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|
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|
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2860 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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2870 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
2880 |
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|
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|
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|
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|
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|
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|
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2890 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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2900 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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2910 |
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|
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|
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|
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|
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|
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2920 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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2930 |
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|
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|
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|
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2940 |
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2950 |
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2960 |
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|
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2970 |
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2980 |
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2990 |
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|
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|
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|
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|
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|
3000 |
L
|
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|
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|
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|
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|
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|
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|
D
|
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|
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3010 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
3020 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3030 |
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|
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3040 |
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|
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3050 |
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|
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|
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|
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|
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|
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3060 |
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|
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|
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|
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|
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|
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|
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3070 |
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|
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|
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|
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|
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|
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|
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|
3080 |
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|
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|
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|
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|
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|
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|
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3090 |
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|
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|
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|
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|
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|
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|
3100 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
3110 |
L
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3120 |
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|
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|
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|
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|
N
|
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|
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|
N
|
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|
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|
3130 |
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|
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|
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|
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|
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|
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|
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|
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|
Y
|
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|
3140 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3150 |
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|
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|
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|
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|
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|
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|
3160 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3170 |
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|
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|
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|
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|
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|
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|
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|
A
|
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|
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|
3180 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3190 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3200 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3210 |
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|
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|
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|
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|
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|
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|
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|
N
|
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|
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|
3220 |
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|
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|
L
|
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|
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|
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|
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|
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|
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|
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|
3230 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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3240 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3250 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3260 |
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|
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|
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|
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|
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|
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|
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|
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|
W
|
3270 |
C
|
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|
F
|
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|
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|
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|
N
|
L
|
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|
Y
|
3280 |
G
|
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|
M
|
L
|
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|
K
|
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|
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|
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|
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|
3290 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3300 |
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|
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|
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|
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|
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|
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|
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|
N
|
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|
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|
3310 |
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|
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|
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|
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|
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|
N
|
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|
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|
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|
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|
3320 |
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|
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|
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|
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|
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|
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|
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|
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|
E
|
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|
3330 |
N
|
E
|
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|
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|
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|
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|
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|
N
|
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|
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|
3340 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
3350 |
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|
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|
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|
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|
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|
I
|
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|
L
|
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|
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|
3360 |
S
|
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|
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|
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|
Y
|
F
|
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|
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|
D
|
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|
3370 |
Q
|
D
|
Y
|
L
|
I
|
I
|
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|
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|
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|
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|
3380 |
D
|
D
|
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|
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|
L
|
T
|
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|
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|
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|
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|
3390 |
W
|
N
|
G
|
G
|
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|
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|
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|
L
|
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|
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|
3400 |
K
|
L
|
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|
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|
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|
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|
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|
L
|
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|
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|
3410 |
A
|
L
|
F
|
N
|
K
|
G
|
G
|
S
|
V
|
F
|
3420 |
L
|
A
|
I
|
S
|
Q
|
A
|
N
|
A
|
R
|
L
|
3430 |
N
|
S
|
L
|
L
|
F
|
R
|
W
|
S
|
G
|
S
|
3440 |
G
|
F
|
I
|
N
|
F
|
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|
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|
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|
P
|
V
|
3450 |
S
|
G
|
T
|
T
|
E
|
V
|
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|
A
|
L
|
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|
3460 |
S
|
A
|
N
|
D
|
I
|
Y
|
L
|
I
|
F
|
A
|
3470 |
E
|
N
|
V
|
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|
L
|
G
|
D
|
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|
N
|
S
|
3480 |
I
|
D
|
I
|
F
|
I
|
W
|
E
|
M
|
G
|
Q
|
3490 |
S
|
S
|
F
|
R
|
Y
|
F
|
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|
S
|
V
|
D
|
3500 |
F
|
A
|
A
|
V
|
N
|
R
|
I
|
H
|
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|
F
|
3510 |
T
|
P
|
A
|
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|
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|
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|
A
|
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|
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|
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|
3520 |
L
|
I
|
G
|
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|
D
|
M
|
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|
A
|
L
|
Y
|
3530 |
C
|
W
|
N
|
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|
E
|
R
|
N
|
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|
F
|
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|
3540 |
F
|
V
|
L
|
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|
V
|
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|
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|
A
|
Y
|
D
|
3550 |
V
|
A
|
S
|
V
|
T
|
V
|
K
|
S
|
L
|
N
|
3560 |
S
|
S
|
K
|
N
|
L
|
I
|
A
|
L
|
V
|
G
|
3570 |
A
|
H
|
S
|
H
|
I
|
Y
|
E
|
L
|
A
|
Y
|
3580 |
I
|
S
|
S
|
H
|
S
|
D
|
F
|
I
|
P
|
S
|
3590 |
S
|
G
|
E
|
L
|
I
|
F
|
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|
P
|
G
|
E
|
3600 |
R
|
E
|
A
|
T
|
I
|
A
|
V
|
N
|
I
|
L
|
3610 |
D
|
D
|
T
|
V
|
P
|
E
|
K
|
E
|
E
|
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|
3620 |
F
|
K
|
V
|
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|
L
|
K
|
N
|
P
|
K
|
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|
3630 |
G
|
A
|
E
|
I
|
G
|
I
|
N
|
D
|
S
|
V
|
3640 |
T
|
I
|
T
|
I
|
L
|
S
|
N
|
D
|
D
|
A
|
3650 |
Y
|
G
|
I
|
V
|
A
|
F
|
A
|
Q
|
N
|
S
|
3660 |
L
|
Y
|
K
|
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|
V
|
E
|
E
|
M
|
E
|
Q
|
3670 |
D
|
S
|
L
|
V
|
T
|
L
|
N
|
V
|
E
|
R
|
3680 |
L
|
K
|
G
|
T
|
Y
|
G
|
R
|
I
|
T
|
I
|
3690 |
A
|
W
|
E
|
A
|
D
|
G
|
S
|
I
|
S
|
D
|
3700 |
I
|
F
|
P
|
T
|
S
|
G
|
V
|
I
|
L
|
F
|
3710 |
T
|
E
|
G
|
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|
V
|
L
|
S
|
T
|
I
|
T
|
3720 |
L
|
T
|
I
|
L
|
A
|
D
|
N
|
I
|
P
|
E
|
3730 |
L
|
S
|
E
|
V
|
V
|
I
|
V
|
T
|
L
|
T
|
3740 |
R
|
I
|
T
|
T
|
E
|
G
|
V
|
E
|
D
|
S
|
3750 |
Y
|
K
|
G
|
A
|
T
|
I
|
D
|
Q
|
D
|
R
|
3760 |
S
|
K
|
S
|
V
|
I
|
T
|
T
|
L
|
P
|
N
|
3770 |
D
|
S
|
P
|
F
|
G
|
L
|
V
|
G
|
W
|
R
|
3780 |
A
|
A
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S
|
V
|
F
|
I
|
R
|
V
|
A
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E
|
3790 |
P
|
K
|
E
|
N
|
T
|
T
|
T
|
L
|
Q
|
L
|
3800 |
Q
|
I
|
A
|
R
|
D
|
K
|
G
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L
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L
|
G
|
3810 |
D
|
I
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A
|
I
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H
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L
|
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A
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Q
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3820 |
N
|
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L
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|
D
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N
|
Q
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3830 |
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|
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|
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|
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|
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3840 |
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|
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3850 |
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|
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|
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|
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|
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|
I
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3860 |
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|
L
|
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E
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|
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|
3870 |
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|
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N
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L
|
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3880 |
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|
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3890 |
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3900 |
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N
|
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D
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3910 |
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3920 |
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Y
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3930 |
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3940 |
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3950 |
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|
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3960 |
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3970 |
H
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3980 |
V
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M
|
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|
T
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|
3990 |
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|
D
|
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|
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L
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|
4000 |
F
|
N
|
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|
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|
L
|
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|
V
|
A
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|
4010 |
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|
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4020 |
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|
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4030 |
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4040 |
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|
4050 |
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|
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|
4060 |
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|
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4070 |
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|
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|
4080 |
K
|
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|
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|
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|
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|
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|
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|
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|
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|
4090 |
L
|
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|
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|
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|
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|
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|
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|
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|
4100 |
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|
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|
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|
L
|
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|
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|
L
|
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|
D
|
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|
4110 |
V
|
L
|
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|
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|
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|
R
|
R
|
F
|
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|
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4120 |
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|
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|
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|
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|
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|
D
|
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|
V
|
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|
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|
4130 |
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|
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|
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|
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|
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|
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|
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|
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|
4140 |
I
|
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|
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|
D
|
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|
R
|
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|
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|
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|
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|
4150 |
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|
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|
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|
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|
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|
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|
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|
R
|
H
|
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|
4160 |
L
|
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|
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|
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|
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|
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|
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|
K
|
Y
|
N
|
4170 |
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|
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|
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|
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|
I
|
S
|
L
|
V
|
R
|
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|
4180 |
P
|
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|
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|
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|
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|
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|
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|
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|
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|
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4190 |
W
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4200 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4210 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4220 |
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|
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|
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|
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|
N
|
D
|
D
|
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|
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|
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|
4230 |
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|
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|
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|
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|
Y
|
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|
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|
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|
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|
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|
4240 |
A
|
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|
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|
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|
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|
G
|
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|
L
|
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|
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|
4250 |
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|
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|
S
|
T
|
A
|
N
|
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|
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|
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|
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|
4260 |
A
|
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|
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|
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|
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|
Y
|
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|
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|
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4270 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4280 |
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|
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|
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|
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|
N
|
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|
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|
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|
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|
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|
4290 |
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|
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|
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|
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|
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4300 |
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|
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|
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|
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|
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|
4310 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4320 |
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|
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|
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4330 |
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|
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|
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|
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|
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|
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4340 |
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|
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4350 |
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|
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4360 |
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|
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|
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|
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|
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|
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|
4370 |
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|
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|
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|
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|
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|
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|
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|
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4380 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4390 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4400 |
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4410 |
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4420 |
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|
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4430 |
Y
|
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|
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|
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4440 |
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|
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|
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4450 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4460 |
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|
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|
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|
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|
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|
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|
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|
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|
4470 |
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|
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|
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|
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|
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|
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|
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|
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|
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4480 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4490 |
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|
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|
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|
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|
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|
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|
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|
4500 |
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|
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|
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4510 |
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4520 |
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4530 |
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|
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|
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4540 |
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4550 |
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|
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|
4560 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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4570 |
D
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4580 |
Y
|
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|
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|
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|
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|
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|
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|
G
|
V
|
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|
4590 |
T
|
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|
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|
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|
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|
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|
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|
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|
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4600 |
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4610 |
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|
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A
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4620 |
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|
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4630 |
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4640 |
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4650 |
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|
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|
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|
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|
4660 |
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|
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|
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|
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|
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|
4670 |
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|
R
|
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|
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|
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|
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|
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|
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|
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|
4680 |
M
|
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|
Y
|
W
|
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|
L
|
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|
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|
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|
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|
4690 |
D
|
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|
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|
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|
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|
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|
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|
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|
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|
4700 |
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|
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|
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|
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|
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|
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4710 |
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|
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|
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4720 |
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|
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|
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|
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|
4730 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4740 |
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|
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|
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|
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|
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|
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|
4750 |
W
|
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|
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|
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|
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|
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|
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|
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|
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|
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4760 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
4770 |
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|
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|
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|
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|
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|
4780 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4790 |
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|
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|
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|
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|
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|
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|
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|
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|
4800 |
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|
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4810 |
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|
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|
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|
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|
4820 |
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|
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|
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|
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|
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|
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4830 |
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|
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|
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|
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|
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|
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|
4840 |
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|
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|
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|
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|
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|
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|
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|
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|
4850 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4860 |
R
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4870 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4880 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4890 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4900 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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4910 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4920 |
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|
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|
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|
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|
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|
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|
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|
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|
4930 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4940 |
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|
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|
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|
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|
4950 |
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|
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|
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|
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|
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|
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|
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|
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|
4960 |
L
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4970 |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
4980 |
Q
|
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|
S
|
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|
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|
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|
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|
A
|
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|
L
|
4990 |
R
|
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|
G
|
F
|
I
|
V
|
A
|
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|
I
|
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|
5000 |
P
|
M
|
G
|
V
|
F
|
Q
|
F
|
S
|
T
|
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|
5010 |
S
|
R
|
N
|
I
|
I
|
V
|
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|
E
|
D
|
T
|
5020 |
Q
|
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|
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|
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|
L
|
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|
V
|
Q
|
R
|
L
|
5030 |
F
|
G
|
F
|
H
|
S
|
D
|
L
|
I
|
K
|
V
|
5040 |
S
|
Y
|
Q
|
T
|
T
|
A
|
G
|
S
|
A
|
K
|
5050 |
P
|
L
|
E
|
D
|
F
|
E
|
P
|
V
|
Q
|
N
|
5060 |
G
|
E
|
L
|
F
|
F
|
Q
|
K
|
F
|
Q
|
T
|
5070 |
E
|
V
|
D
|
F
|
E
|
I
|
T
|
I
|
I
|
N
|
5080 |
D
|
Q
|
L
|
S
|
E
|
I
|
E
|
E
|
F
|
F
|
5090 |
Y
|
I
|
N
|
L
|
T
|
S
|
V
|
E
|
I
|
R
|
5100 |
G
|
L
|
Q
|
K
|
F
|
D
|
V
|
N
|
W
|
S
|
5110 |
P
|
R
|
L
|
N
|
L
|
D
|
F
|
S
|
V
|
A
|
5120 |
V
|
I
|
T
|
I
|
L
|
D
|
N
|
D
|
D
|
L
|
5130 |
A
|
G
|
M
|
D
|
I
|
S
|
F
|
P
|
E
|
T
|
5140 |
T
|
V
|
A
|
V
|
A
|
V
|
D
|
T
|
T
|
L
|
5150 |
I
|
P
|
V
|
E
|
T
|
E
|
S
|
T
|
T
|
Y
|
5160 |
L
|
S
|
T
|
S
|
K
|
T
|
T
|
T
|
I
|
L
|
5170 |
Q
|
P
|
T
|
N
|
V
|
V
|
A
|
I
|
V
|
T
|
5180 |
E
|
A
|
T
|
G
|
V
|
S
|
A
|
I
|
P
|
E
|
5190 |
K
|
L
|
V
|
T
|
L
|
H
|
G
|
T
|
P
|
A
|
5200 |
V
|
S
|
E
|
K
|
P
|
D
|
V
|
A
|
T
|
V
|
5210 |
T
|
A
|
N
|
V
|
S
|
I
|
H
|
G
|
T
|
F
|
5220 |
S
|
L
|
G
|
P
|
S
|
I
|
V
|
Y
|
I
|
E
|
5230 |
E
|
E
|
M
|
K
|
N
|
G
|
T
|
F
|
N
|
T
|
5240 |
A
|
E
|
V
|
L
|
I
|
R
|
R
|
T
|
G
|
G
|
5250 |
F
|
T
|
G
|
N
|
V
|
S
|
I
|
T
|
V
|
K
|
5260 |
T
|
F
|
G
|
E
|
R
|
C
|
A
|
Q
|
M
|
E
|
5270 |
P
|
N
|
A
|
L
|
P
|
F
|
R
|
G
|
I
|
Y
|
5280 |
G
|
I
|
S
|
N
|
L
|
T
|
W
|
A
|
V
|
E
|
5290 |
E
|
E
|
D
|
F
|
E
|
E
|
Q
|
T
|
L
|
T
|
5300 |
L
|
I
|
F
|
L
|
D
|
G
|
E
|
R
|
E
|
R
|
5310 |
K
|
V
|
S
|
V
|
Q
|
I
|
L
|
D
|
D
|
D
|
5320 |
E
|
P
|
E
|
G
|
Q
|
E
|
F
|
F
|
Y
|
V
|
5330 |
F
|
L
|
T
|
N
|
P
|
Q
|
G
|
G
|
A
|
Q
|
5340 |
I
|
V
|
E
|
E
|
K
|
D
|
D
|
T
|
G
|
F
|
5350 |
A
|
A
|
F
|
A
|
M
|
V
|
I
|
I
|
T
|
G
|
5360 |
S
|
D
|
L
|
H
|
N
|
G
|
I
|
I
|
G
|
F
|
5370 |
S
|
E
|
E
|
S
|
Q
|
S
|
G
|
L
|
E
|
L
|
5380 |
R
|
E
|
G
|
A
|
V
|
M
|
R
|
R
|
L
|
H
|
5390 |
L
|
I
|
V
|
T
|
R
|
Q
|
P
|
N
|
R
|
A
|
5400 |
F
|
E
|
D
|
V
|
K
|
V
|
F
|
W
|
R
|
V
|
5410 |
T
|
L
|
N
|
K
|
T
|
V
|
V
|
V
|
L
|
Q
|
5420 |
K
|
D
|
G
|
V
|
N
|
L
|
V
|
E
|
E
|
L
|
5430 |
Q
|
S
|
V
|
S
|
G
|
T
|
T
|
T
|
C
|
T
|
5440 |
M
|
G
|
Q
|
T
|
K
|
C
|
F
|
I
|
S
|
I
|
5450 |
E
|
L
|
K
|
P
|
E
|
K
|
V
|
P
|
Q
|
V
|
5460 |
E
|
V
|
Y
|
F
|
F
|
V
|
E
|
L
|
Y
|
E
|
5470 |
A
|
T
|
A
|
G
|
A
|
A
|
I
|
N
|
N
|
S
|
5480 |
A
|
R
|
F
|
A
|
Q
|
I
|
K
|
I
|
L
|
E
|
5490 |
S
|
D
|
E
|
S
|
Q
|
S
|
L
|
V
|
Y
|
F
|
5500 |
S
|
V
|
G
|
S
|
R
|
L
|
A
|
V
|
A
|
H
|
5510 |
K
|
K
|
A
|
T
|
L
|
I
|
S
|
L
|
Q
|
V
|
5520 |
A
|
R
|
D
|
S
|
G
|
T
|
G
|
L
|
M
|
M
|
5530 |
S
|
V
|
N
|
F
|
S
|
T
|
Q
|
E
|
L
|
R
|
5540 |
S
|
A
|
E
|
T
|
I
|
G
|
R
|
T
|
I
|
I
|
5550 |
S
|
P
|
A
|
I
|
S
|
G
|
K
|
D
|
F
|
V
|
5560 |
I
|
T
|
E
|
G
|
T
|
L
|
V
|
F
|
E
|
P
|
5570 |
G
|
Q
|
R
|
S
|
T
|
V
|
L
|
D
|
V
|
I
|
5580 |
L
|
T
|
P
|
E
|
T
|
G
|
S
|
L
|
N
|
S
|
5590 |
F
|
P
|
K
|
R
|
F
|
Q
|
I
|
V
|
L
|
F
|
5600 |
D
|
P
|
K
|
G
|
G
|
A
|
R
|
I
|
D
|
K
|
5610 |
V
|
Y
|
G
|
T
|
A
|
N
|
I
|
T
|
L
|
V
|
5620 |
S
|
D
|
A
|
D
|
S
|
Q
|
A
|
I
|
W
|
G
|
5630 |
L
|
A
|
D
|
Q
|
L
|
H
|
Q
|
P
|
V
|
N
|
5640 |
D
|
D
|
I
|
L
|
N
|
R
|
V
|
L
|
H
|
T
|
5650 |
I
|
S
|
M
|
K
|
V
|
A
|
T
|
E
|
N
|
T
|
5660 |
D
|
E
|
Q
|
L
|
S
|
A
|
M
|
M
|
H
|
L
|
5670 |
I
|
E
|
K
|
I
|
T
|
T
|
E
|
G
|
K
|
I
|
5680 |
Q
|
A
|
F
|
S
|
V
|
A
|
S
|
R
|
T
|
L
|
5690 |
F
|
Y
|
E
|
I
|
L
|
C
|
S
|
L
|
I
|
N
|
5700 |
P
|
K
|
R
|
K
|
D
|
T
|
R
|
G
|
F
|
S
|
5710 |
H
|
F
|
A
|
E
|
V
|
T
|
E
|
N
|
F
|
A
|
5720 |
F
|
S
|
L
|
L
|
T
|
N
|
V
|
T
|
C
|
G
|
5730 |
S
|
P
|
G
|
E
|
K
|
S
|
K
|
T
|
I
|
L
|
5740 |
D
|
S
|
C
|
P
|
Y
|
L
|
S
|
I
|
L
|
A
|
5750 |
L
|
H
|
W
|
Y
|
P
|
Q
|
Q
|
I
|
N
|
G
|
5760 |
H
|
K
|
F
|
E
|
G
|
K
|
E
|
G
|
D
|
Y
|
5770 |
I
|
R
|
I
|
P
|
E
|
R
|
L
|
L
|
D
|
V
|
5780 |
Q
|
D
|
A
|
E
|
I
|
M
|
A
|
G
|
K
|
S
|
5790 |
T
|
C
|
K
|
L
|
V
|
Q
|
F
|
T
|
E
|
Y
|
5800 |
S
|
S
|
Q
|
Q
|
W
|
F
|
I
|
S
|
G
|
N
|
5810 |
N
|
L
|
P
|
T
|
L
|
K
|
N
|
K
|
V
|
L
|
5820 |
S
|
L
|
S
|
V
|
K
|
G
|
Q
|
S
|
S
|
Q
|
5830 |
L
|
L
|
T
|
N
|
D
|
N
|
E
|
V
|
L
|
Y
|
5840 |
R
|
I
|
Y
|
A
|
A
|
E
|
P
|
R
|
I
|
I
|
5850 |
P
|
Q
|
T
|
S
|
L
|
C
|
L
|
L
|
W
|
N
|
5860 |
Q
|
A
|
A
|
A
|
S
|
W
|
L
|
S
|
D
|
S
|
5870 |
Q
|
F
|
C
|
K
|
V
|
V
|
E
|
E
|
T
|
A
|
5880 |
D
|
Y
|
V
|
E
|
C
|
A
|
C
|
S
|
H
|
M
|
5890 |
S
|
V
|
Y
|
A
|
V
|
Y
|
A
|
R
|
T
|
D
|
5900 |
TM1 | |||||||||
N
|
L
|
S
|
S
|
Y
|
N
|
E
|
A
|
F
|
F
|
5910 |
T
|
S
|
G
|
F
|
I
|
C
|
I
|
S
|
G
|
L
|
5920 |
C
|
L
|
A
|
V
|
L
|
S
|
H
|
I
|
F
|
C
|
5930 |
ICL1 | TM2 | ||||||||
A
|
R
|
Y
|
S
|
M
|
F
|
A
|
A
|
K
|
L
|
5940 |
L
|
T
|
H
|
M
|
M
|
A
|
A
|
S
|
L
|
G
|
5950 |
T
|
Q
|
I
|
L
|
F
|
L
|
A
|
S
|
A
|
Y
|
5960 |
ECL1 | TM3 | ||||||||
A
|
S
|
P
|
Q
|
L
|
A
|
E
|
E
|
S
|
C
|
5970 |
S
|
A
|
M
|
A
|
A
|
V
|
T
|
H
|
Y
|
L
|
5980 |
Y
|
L
|
C
|
Q
|
F
|
S
|
W
|
M
|
L
|
I
|
5990 |
Q
|
S
|
V
|
N
|
F
|
W
|
Y
|
V
|
L
|
V
|
6000 |
ICL2 | |||||||||
M
|
N
|
D
|
E
|
H
|
T
|
E
|
R
|
R
|
Y
|
6010 |
TM4 | |||||||||
L
|
L
|
F
|
F
|
L
|
L
|
S
|
W
|
G
|
L
|
6020 |
P
|
A
|
F
|
V
|
V
|
I
|
L
|
L
|
I
|
V
|
6030 |
ECL2 | |||||||||
I
|
L
|
K
|
G
|
I
|
Y
|
H
|
Q
|
S
|
M
|
6040 |
S
|
Q
|
I
|
Y
|
G
|
L
|
I
|
H
|
G
|
D
|
6050 |
L
|
C
|
F
|
I
|
P
|
N
|
V
|
Y
|
A
|
A
|
6060 |
TM5 | |||||||||
L
|
F
|
T
|
A
|
A
|
L
|
V
|
P
|
L
|
T
|
6070 |
C
|
L
|
V
|
V
|
V
|
F
|
V
|
V
|
F
|
I
|
6080 |
H
|
A
|
Y
|
Q
|
V
|
K
|
P
|
Q
|
W
|
K
|
6090 |
ICL3 | |||||||||
A
|
Y
|
D
|
D
|
V
|
F
|
R
|
G
|
R
|
T
|
6100 |
TM6 | |||||||||
N
|
A
|
A
|
E
|
I
|
P
|
L
|
I
|
L
|
Y
|
6110 |
L
|
F
|
A
|
L
|
I
|
S
|
V
|
T
|
W
|
L
|
6120 |
ECL3 | |||||||||
W
|
G
|
G
|
L
|
H
|
M
|
A
|
Y
|
R
|
H
|
6130 |
TM7 | |||||||||
F
|
W
|
M
|
L
|
V
|
L
|
F
|
V
|
I
|
F
|
6140 |
N
|
S
|
L
|
Q
|
G
|
L
|
Y
|
V
|
F
|
M
|
6150 |
H8 | |||||||||
V
|
Y
|
F
|
I
|
L
|
H
|
N
|
Q
|
M
|
C
|
6160 |
C
|
P
|
M
|
K
|
A
|
S
|
Y
|
T
|
V
|
E
|
6170 |
C-term | |||||||||
M
|
N
|
G
|
H
|
P
|
G
|
P
|
S
|
T
|
A
|
6180 |
F
|
F
|
T
|
P
|
G
|
S
|
G
|
M
|
P
|
P
|
6190 |
A
|
G
|
G
|
E
|
I
|
S
|
K
|
S
|
T
|
Q
|
6200 |
N
|
L
|
I
|
G
|
A
|
M
|
E
|
E
|
V
|
P
|
6210 |
P
|
D
|
W
|
E
|
R
|
A
|
S
|
F
|
Q
|
Q
|
6220 |
G
|
S
|
Q
|
A
|
S
|
P
|
D
|
L
|
K
|
P
|
6230 |
S
|
P
|
Q
|
N
|
G
|
A
|
T
|
F
|
P
|
S
|
6240 |
S
|
G
|
G
|
Y
|
G
|
Q
|
G
|
S
|
L
|
I
|
6250 |
A
|
D
|
E
|
E
|
S
|
Q
|
E
|
F
|
D
|
D
|
6260 |
L
|
I
|
F
|
A
|
L
|
K
|
T
|
G
|
A
|
G
|
6270 |
L
|
S
|
V
|
S
|
D
|
N
|
E
|
S
|
G
|
Q
|
6280 |
G
|
S
|
Q
|
E
|
G
|
G
|
T
|
L
|
T
|
D
|
6290 |
S
|
Q
|
I
|
V
|
E
|
L
|
R
|
R
|
I
|
P
|
6300 |
I
|
A
|
D
|
T
|
H
|
L
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available