CELSR2 (celr2_human)
FAMILY
Class B2 (Adhesion) Adhesion receptors ADGRC CELSR2
GENE
CELSR2 (CDHF10, EGFL2, KIAA0279, MEGF3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, Epidermal growth factor-like protein 2, EGF-like protein 2, Flamingo homolog 3, Multiple epidermal growth factor-like domains protein 3, Multiple EGF-like domains protein 3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
S
|
P
|
A
|
T
|
G
|
V
|
P
|
L
|
10 |
P
|
T
|
P
|
P
|
P
|
P
|
L
|
L
|
L
|
L
|
20 |
L
|
L
|
L
|
L
|
L
|
P
|
P
|
P
|
L
|
L
|
30 |
G
|
D
|
Q
|
V
|
G
|
P
|
C
|
R
|
S
|
L
|
40 |
G
|
S
|
R
|
G
|
R
|
G
|
S
|
S
|
G
|
A
|
50 |
C
|
A
|
P
|
M
|
G
|
W
|
L
|
C
|
P
|
S
|
60 |
S
|
A
|
S
|
N
|
L
|
W
|
L
|
Y
|
T
|
S
|
70 |
R
|
C
|
R
|
D
|
A
|
G
|
T
|
E
|
L
|
T
|
80 |
G
|
H
|
L
|
V
|
P
|
H
|
H
|
D
|
G
|
L
|
90 |
R
|
V
|
W
|
C
|
P
|
E
|
S
|
E
|
A
|
H
|
100 |
I
|
P
|
L
|
P
|
P
|
A
|
P
|
E
|
G
|
C
|
110 |
P
|
W
|
S
|
C
|
R
|
L
|
L
|
G
|
I
|
G
|
120 |
G
|
H
|
L
|
S
|
P
|
Q
|
G
|
K
|
L
|
T
|
130 |
L
|
P
|
E
|
E
|
H
|
P
|
C
|
L
|
K
|
A
|
140 |
P
|
R
|
L
|
R
|
C
|
Q
|
S
|
C
|
K
|
L
|
150 |
A
|
Q
|
A
|
P
|
G
|
L
|
R
|
A
|
G
|
E
|
160 |
R
|
S
|
P
|
E
|
E
|
S
|
L
|
G
|
G
|
R
|
170 |
R
|
K
|
R
|
N
|
V
|
N
|
T
|
A
|
P
|
Q
|
180 |
F
|
Q
|
P
|
P
|
S
|
Y
|
Q
|
A
|
T
|
V
|
190 |
P
|
E
|
N
|
Q
|
P
|
A
|
G
|
T
|
P
|
V
|
200 |
A
|
S
|
L
|
R
|
A
|
I
|
D
|
P
|
D
|
E
|
210 |
G
|
E
|
A
|
G
|
R
|
L
|
E
|
Y
|
T
|
M
|
220 |
D
|
A
|
L
|
F
|
D
|
S
|
R
|
S
|
N
|
Q
|
230 |
F
|
F
|
S
|
L
|
D
|
P
|
V
|
T
|
G
|
A
|
240 |
V
|
T
|
T
|
A
|
E
|
E
|
L
|
D
|
R
|
E
|
250 |
T
|
K
|
S
|
T
|
H
|
V
|
F
|
R
|
V
|
T
|
260 |
A
|
Q
|
D
|
H
|
G
|
M
|
P
|
R
|
R
|
S
|
270 |
A
|
L
|
A
|
T
|
L
|
T
|
I
|
L
|
V
|
T
|
280 |
D
|
T
|
N
|
D
|
H
|
D
|
P
|
V
|
F
|
E
|
290 |
Q
|
Q
|
E
|
Y
|
K
|
E
|
S
|
L
|
R
|
E
|
300 |
N
|
L
|
E
|
V
|
G
|
Y
|
E
|
V
|
L
|
T
|
310 |
V
|
R
|
A
|
T
|
D
|
G
|
D
|
A
|
P
|
P
|
320 |
N
|
A
|
N
|
I
|
L
|
Y
|
R
|
L
|
L
|
E
|
330 |
G
|
S
|
G
|
G
|
S
|
P
|
S
|
E
|
V
|
F
|
340 |
E
|
I
|
D
|
P
|
R
|
S
|
G
|
V
|
I
|
R
|
350 |
T
|
R
|
G
|
P
|
V
|
D
|
R
|
E
|
E
|
V
|
360 |
E
|
S
|
Y
|
Q
|
L
|
T
|
V
|
E
|
A
|
S
|
370 |
D
|
Q
|
G
|
R
|
D
|
P
|
G
|
P
|
R
|
S
|
380 |
T
|
T
|
A
|
A
|
V
|
F
|
L
|
S
|
V
|
E
|
390 |
D
|
D
|
N
|
D
|
N
|
A
|
P
|
Q
|
F
|
S
|
400 |
E
|
K
|
R
|
Y
|
V
|
V
|
Q
|
V
|
R
|
E
|
410 |
D
|
V
|
T
|
P
|
G
|
A
|
P
|
V
|
L
|
R
|
420 |
V
|
T
|
A
|
S
|
D
|
R
|
D
|
K
|
G
|
S
|
430 |
N
|
A
|
V
|
V
|
H
|
Y
|
S
|
I
|
M
|
S
|
440 |
G
|
N
|
A
|
R
|
G
|
Q
|
F
|
Y
|
L
|
D
|
450 |
A
|
Q
|
T
|
G
|
A
|
L
|
D
|
V
|
V
|
S
|
460 |
P
|
L
|
D
|
Y
|
E
|
T
|
T
|
K
|
E
|
Y
|
470 |
T
|
L
|
R
|
V
|
R
|
A
|
Q
|
D
|
G
|
G
|
480 |
R
|
P
|
P
|
L
|
S
|
N
|
V
|
S
|
G
|
L
|
490 |
V
|
T
|
V
|
Q
|
V
|
L
|
D
|
I
|
N
|
D
|
500 |
N
|
A
|
P
|
I
|
F
|
V
|
S
|
T
|
P
|
F
|
510 |
Q
|
A
|
T
|
V
|
L
|
E
|
S
|
V
|
P
|
L
|
520 |
G
|
Y
|
L
|
V
|
L
|
H
|
V
|
Q
|
A
|
I
|
530 |
D
|
A
|
D
|
A
|
G
|
D
|
N
|
A
|
R
|
L
|
540 |
E
|
Y
|
R
|
L
|
A
|
G
|
V
|
G
|
H
|
D
|
550 |
F
|
P
|
F
|
T
|
I
|
N
|
N
|
G
|
T
|
G
|
560 |
W
|
I
|
S
|
V
|
A
|
A
|
E
|
L
|
D
|
R
|
570 |
E
|
E
|
V
|
D
|
F
|
Y
|
S
|
F
|
G
|
V
|
580 |
E
|
A
|
R
|
D
|
H
|
G
|
T
|
P
|
A
|
L
|
590 |
T
|
A
|
S
|
A
|
S
|
V
|
S
|
V
|
T
|
V
|
600 |
L
|
D
|
V
|
N
|
D
|
N
|
N
|
P
|
T
|
F
|
610 |
T
|
Q
|
P
|
E
|
Y
|
T
|
V
|
R
|
L
|
N
|
620 |
E
|
D
|
A
|
A
|
V
|
G
|
T
|
S
|
V
|
V
|
630 |
T
|
V
|
S
|
A
|
V
|
D
|
R
|
D
|
A
|
H
|
640 |
S
|
V
|
I
|
T
|
Y
|
Q
|
I
|
T
|
S
|
G
|
650 |
N
|
T
|
R
|
N
|
R
|
F
|
S
|
I
|
T
|
S
|
660 |
Q
|
S
|
G
|
G
|
G
|
L
|
V
|
S
|
L
|
A
|
670 |
L
|
P
|
L
|
D
|
Y
|
K
|
L
|
E
|
R
|
Q
|
680 |
Y
|
V
|
L
|
A
|
V
|
T
|
A
|
S
|
D
|
G
|
690 |
T
|
R
|
Q
|
D
|
T
|
A
|
Q
|
I
|
V
|
V
|
700 |
N
|
V
|
T
|
D
|
A
|
N
|
T
|
H
|
R
|
P
|
710 |
V
|
F
|
Q
|
S
|
S
|
H
|
Y
|
T
|
V
|
N
|
720 |
V
|
N
|
E
|
D
|
R
|
P
|
A
|
G
|
T
|
T
|
730 |
V
|
V
|
L
|
I
|
S
|
A
|
T
|
D
|
E
|
D
|
740 |
T
|
G
|
E
|
N
|
A
|
R
|
I
|
T
|
Y
|
F
|
750 |
M
|
E
|
D
|
S
|
I
|
P
|
Q
|
F
|
R
|
I
|
760 |
D
|
A
|
D
|
T
|
G
|
A
|
V
|
T
|
T
|
Q
|
770 |
A
|
E
|
L
|
D
|
Y
|
E
|
D
|
Q
|
V
|
S
|
780 |
Y
|
T
|
L
|
A
|
I
|
T
|
A
|
R
|
D
|
N
|
790 |
G
|
I
|
P
|
Q
|
K
|
S
|
D
|
T
|
T
|
Y
|
800 |
L
|
E
|
I
|
L
|
V
|
N
|
D
|
V
|
N
|
D
|
810 |
N
|
A
|
P
|
Q
|
F
|
L
|
R
|
D
|
S
|
Y
|
820 |
Q
|
G
|
S
|
V
|
Y
|
E
|
D
|
V
|
P
|
P
|
830 |
F
|
T
|
S
|
V
|
L
|
Q
|
I
|
S
|
A
|
T
|
840 |
D
|
R
|
D
|
S
|
G
|
L
|
N
|
G
|
R
|
V
|
850 |
F
|
Y
|
T
|
F
|
Q
|
G
|
G
|
D
|
D
|
G
|
860 |
D
|
G
|
D
|
F
|
I
|
V
|
E
|
S
|
T
|
S
|
870 |
G
|
I
|
V
|
R
|
T
|
L
|
R
|
R
|
L
|
D
|
880 |
R
|
E
|
N
|
V
|
A
|
Q
|
Y
|
V
|
L
|
R
|
890 |
A
|
Y
|
A
|
V
|
D
|
K
|
G
|
M
|
P
|
P
|
900 |
A
|
R
|
T
|
P
|
M
|
E
|
V
|
T
|
V
|
T
|
910 |
V
|
L
|
D
|
V
|
N
|
D
|
N
|
P
|
P
|
V
|
920 |
F
|
E
|
Q
|
D
|
E
|
F
|
D
|
V
|
F
|
V
|
930 |
E
|
E
|
N
|
S
|
P
|
I
|
G
|
L
|
A
|
V
|
940 |
A
|
R
|
V
|
T
|
A
|
T
|
D
|
P
|
D
|
E
|
950 |
G
|
T
|
N
|
A
|
Q
|
I
|
M
|
Y
|
Q
|
I
|
960 |
V
|
E
|
G
|
N
|
I
|
P
|
E
|
V
|
F
|
Q
|
970 |
L
|
D
|
I
|
F
|
S
|
G
|
E
|
L
|
T
|
A
|
980 |
L
|
V
|
D
|
L
|
D
|
Y
|
E
|
D
|
R
|
P
|
990 |
E
|
Y
|
V
|
L
|
V
|
I
|
Q
|
A
|
T
|
S
|
1000 |
A
|
P
|
L
|
V
|
S
|
R
|
A
|
T
|
V
|
H
|
1010 |
V
|
R
|
L
|
L
|
D
|
R
|
N
|
D
|
N
|
P
|
1020 |
P
|
V
|
L
|
G
|
N
|
F
|
E
|
I
|
L
|
F
|
1030 |
N
|
N
|
Y
|
V
|
T
|
N
|
R
|
S
|
S
|
S
|
1040 |
F
|
P
|
G
|
G
|
A
|
I
|
G
|
R
|
V
|
P
|
1050 |
A
|
H
|
D
|
P
|
D
|
I
|
S
|
D
|
S
|
L
|
1060 |
T
|
Y
|
S
|
F
|
E
|
R
|
G
|
N
|
E
|
L
|
1070 |
S
|
L
|
V
|
L
|
L
|
N
|
A
|
S
|
T
|
G
|
1080 |
E
|
L
|
K
|
L
|
S
|
R
|
A
|
L
|
D
|
N
|
1090 |
N
|
R
|
P
|
L
|
E
|
A
|
I
|
M
|
S
|
V
|
1100 |
L
|
V
|
S
|
D
|
G
|
V
|
H
|
S
|
V
|
T
|
1110 |
A
|
Q
|
C
|
A
|
L
|
R
|
V
|
T
|
I
|
I
|
1120 |
T
|
D
|
E
|
M
|
L
|
T
|
H
|
S
|
I
|
T
|
1130 |
L
|
R
|
L
|
E
|
D
|
M
|
S
|
P
|
E
|
R
|
1140 |
F
|
L
|
S
|
P
|
L
|
L
|
G
|
L
|
F
|
I
|
1150 |
Q
|
A
|
V
|
A
|
A
|
T
|
L
|
A
|
T
|
P
|
1160 |
P
|
D
|
H
|
V
|
V
|
V
|
F
|
N
|
V
|
Q
|
1170 |
R
|
D
|
T
|
D
|
A
|
P
|
G
|
G
|
H
|
I
|
1180 |
L
|
N
|
V
|
S
|
L
|
S
|
V
|
G
|
Q
|
P
|
1190 |
P
|
G
|
P
|
G
|
G
|
G
|
P
|
P
|
F
|
L
|
1200 |
P
|
S
|
E
|
D
|
L
|
Q
|
E
|
R
|
L
|
Y
|
1210 |
L
|
N
|
R
|
S
|
L
|
L
|
T
|
A
|
I
|
S
|
1220 |
A
|
Q
|
R
|
V
|
L
|
P
|
F
|
D
|
D
|
N
|
1230 |
I
|
C
|
L
|
R
|
E
|
P
|
C
|
E
|
N
|
Y
|
1240 |
M
|
R
|
C
|
V
|
S
|
V
|
L
|
R
|
F
|
D
|
1250 |
S
|
S
|
A
|
P
|
F
|
I
|
A
|
S
|
S
|
S
|
1260 |
V
|
L
|
F
|
R
|
P
|
I
|
H
|
P
|
V
|
G
|
1270 |
G
|
L
|
R
|
C
|
R
|
C
|
P
|
P
|
G
|
F
|
1280 |
T
|
G
|
D
|
Y
|
C
|
E
|
T
|
E
|
V
|
D
|
1290 |
L
|
C
|
Y
|
S
|
R
|
P
|
C
|
G
|
P
|
H
|
1300 |
G
|
R
|
C
|
R
|
S
|
R
|
E
|
G
|
G
|
Y
|
1310 |
T
|
C
|
L
|
C
|
R
|
D
|
G
|
Y
|
T
|
G
|
1320 |
E
|
H
|
C
|
E
|
V
|
S
|
A
|
R
|
S
|
G
|
1330 |
R
|
C
|
T
|
P
|
G
|
V
|
C
|
K
|
N
|
G
|
1340 |
G
|
T
|
C
|
V
|
N
|
L
|
L
|
V
|
G
|
G
|
1350 |
F
|
K
|
C
|
D
|
C
|
P
|
S
|
G
|
D
|
F
|
1360 |
E
|
K
|
P
|
Y
|
C
|
Q
|
V
|
T
|
T
|
R
|
1370 |
S
|
F
|
P
|
A
|
H
|
S
|
F
|
I
|
T
|
F
|
1380 |
R
|
G
|
L
|
R
|
Q
|
R
|
F
|
H
|
F
|
T
|
1390 |
L
|
A
|
L
|
S
|
F
|
A
|
T
|
K
|
E
|
R
|
1400 |
D
|
G
|
L
|
L
|
L
|
Y
|
N
|
G
|
R
|
F
|
1410 |
N
|
E
|
K
|
H
|
D
|
F
|
V
|
A
|
L
|
E
|
1420 |
V
|
I
|
Q
|
E
|
Q
|
V
|
Q
|
L
|
T
|
F
|
1430 |
S
|
A
|
G
|
E
|
S
|
T
|
T
|
T
|
V
|
S
|
1440 |
P
|
F
|
V
|
P
|
G
|
G
|
V
|
S
|
D
|
G
|
1450 |
Q
|
W
|
H
|
T
|
V
|
Q
|
L
|
K
|
Y
|
Y
|
1460 |
N
|
K
|
P
|
L
|
L
|
G
|
Q
|
T
|
G
|
L
|
1470 |
P
|
Q
|
G
|
P
|
S
|
E
|
Q
|
K
|
V
|
A
|
1480 |
V
|
V
|
T
|
V
|
D
|
G
|
C
|
D
|
T
|
G
|
1490 |
V
|
A
|
L
|
R
|
F
|
G
|
S
|
V
|
L
|
G
|
1500 |
N
|
Y
|
S
|
C
|
A
|
A
|
Q
|
G
|
T
|
Q
|
1510 |
G
|
G
|
S
|
K
|
K
|
S
|
L
|
D
|
L
|
T
|
1520 |
G
|
P
|
L
|
L
|
L
|
G
|
G
|
V
|
P
|
D
|
1530 |
L
|
P
|
E
|
S
|
F
|
P
|
V
|
R
|
M
|
R
|
1540 |
Q
|
F
|
V
|
G
|
C
|
M
|
R
|
N
|
L
|
Q
|
1550 |
V
|
D
|
S
|
R
|
H
|
I
|
D
|
M
|
A
|
D
|
1560 |
F
|
I
|
A
|
N
|
N
|
G
|
T
|
V
|
P
|
G
|
1570 |
C
|
P
|
A
|
K
|
K
|
N
|
V
|
C
|
D
|
S
|
1580 |
N
|
T
|
C
|
H
|
N
|
G
|
G
|
T
|
C
|
V
|
1590 |
N
|
Q
|
W
|
D
|
A
|
F
|
S
|
C
|
E
|
C
|
1600 |
P
|
L
|
G
|
F
|
G
|
G
|
K
|
S
|
C
|
A
|
1610 |
Q
|
E
|
M
|
A
|
N
|
P
|
Q
|
H
|
F
|
L
|
1620 |
G
|
S
|
S
|
L
|
V
|
A
|
W
|
H
|
G
|
L
|
1630 |
S
|
L
|
P
|
I
|
S
|
Q
|
P
|
W
|
Y
|
L
|
1640 |
S
|
L
|
M
|
F
|
R
|
T
|
R
|
Q
|
A
|
D
|
1650 |
G
|
V
|
L
|
L
|
Q
|
A
|
I
|
T
|
R
|
G
|
1660 |
R
|
S
|
T
|
I
|
T
|
L
|
Q
|
L
|
R
|
E
|
1670 |
G
|
H
|
V
|
M
|
L
|
S
|
V
|
E
|
G
|
T
|
1680 |
G
|
L
|
Q
|
A
|
S
|
S
|
L
|
R
|
L
|
E
|
1690 |
P
|
G
|
R
|
A
|
N
|
D
|
G
|
D
|
W
|
H
|
1700 |
H
|
A
|
Q
|
L
|
A
|
L
|
G
|
A
|
S
|
G
|
1710 |
G
|
P
|
G
|
H
|
A
|
I
|
L
|
S
|
F
|
D
|
1720 |
Y
|
G
|
Q
|
Q
|
R
|
A
|
E
|
G
|
N
|
L
|
1730 |
G
|
P
|
R
|
L
|
H
|
G
|
L
|
H
|
L
|
S
|
1740 |
N
|
I
|
T
|
V
|
G
|
G
|
I
|
P
|
G
|
P
|
1750 |
A
|
G
|
G
|
V
|
A
|
R
|
G
|
F
|
R
|
G
|
1760 |
C
|
L
|
Q
|
G
|
V
|
R
|
V
|
S
|
D
|
T
|
1770 |
P
|
E
|
G
|
V
|
N
|
S
|
L
|
D
|
P
|
S
|
1780 |
H
|
G
|
E
|
S
|
I
|
N
|
V
|
E
|
Q
|
G
|
1790 |
C
|
S
|
L
|
P
|
D
|
P
|
C
|
D
|
S
|
N
|
1800 |
P
|
C
|
P
|
A
|
N
|
S
|
Y
|
C
|
S
|
N
|
1810 |
D
|
W
|
D
|
S
|
Y
|
S
|
C
|
S
|
C
|
D
|
1820 |
P
|
G
|
Y
|
Y
|
G
|
D
|
N
|
C
|
T
|
N
|
1830 |
V
|
C
|
D
|
L
|
N
|
P
|
C
|
E
|
H
|
Q
|
1840 |
S
|
V
|
C
|
T
|
R
|
K
|
P
|
S
|
A
|
P
|
1850 |
H
|
G
|
Y
|
T
|
C
|
E
|
C
|
P
|
P
|
N
|
1860 |
Y
|
L
|
G
|
P
|
Y
|
C
|
E
|
T
|
R
|
I
|
1870 |
D
|
Q
|
P
|
C
|
P
|
R
|
G
|
W
|
W
|
G
|
1880 |
H
|
P
|
T
|
C
|
G
|
P
|
C
|
N
|
C
|
D
|
1890 |
V
|
S
|
K
|
G
|
F
|
D
|
P
|
D
|
C
|
N
|
1900 |
K
|
T
|
S
|
G
|
E
|
C
|
H
|
C
|
K
|
E
|
1910 |
N
|
H
|
Y
|
R
|
P
|
P
|
G
|
S
|
P
|
T
|
1920 |
C
|
L
|
L
|
C
|
D
|
C
|
Y
|
P
|
T
|
G
|
1930 |
S
|
L
|
S
|
R
|
V
|
C
|
D
|
P
|
E
|
D
|
1940 |
G
|
Q
|
C
|
P
|
C
|
K
|
P
|
G
|
V
|
I
|
1950 |
G
|
R
|
Q
|
C
|
D
|
R
|
C
|
D
|
N
|
P
|
1960 |
F
|
A
|
E
|
V
|
T
|
T
|
N
|
G
|
C
|
E
|
1970 |
V
|
N
|
Y
|
D
|
S
|
C
|
P
|
R
|
A
|
I
|
1980 |
E
|
A
|
G
|
I
|
W
|
W
|
P
|
R
|
T
|
R
|
1990 |
F
|
G
|
L
|
P
|
A
|
A
|
A
|
P
|
C
|
P
|
2000 |
K
|
G
|
S
|
F
|
G
|
T
|
A
|
V
|
R
|
H
|
2010 |
C
|
D
|
E
|
H
|
R
|
G
|
W
|
L
|
P
|
P
|
2020 |
N
|
L
|
F
|
N
|
C
|
T
|
S
|
I
|
T
|
F
|
2030 |
S
|
E
|
L
|
K
|
G
|
F
|
A
|
E
|
R
|
L
|
2040 |
Q
|
R
|
N
|
E
|
S
|
G
|
L
|
D
|
S
|
G
|
2050 |
R
|
S
|
Q
|
Q
|
L
|
A
|
L
|
L
|
L
|
R
|
2060 |
N
|
A
|
T
|
Q
|
H
|
T
|
A
|
G
|
Y
|
F
|
2070 |
G
|
S
|
D
|
V
|
K
|
V
|
A
|
Y
|
Q
|
L
|
2080 |
A
|
T
|
R
|
L
|
L
|
A
|
H
|
E
|
S
|
T
|
2090 |
Q
|
R
|
G
|
F
|
G
|
L
|
S
|
A
|
T
|
Q
|
2100 |
D
|
V
|
H
|
F
|
T
|
E
|
N
|
L
|
L
|
R
|
2110 |
V
|
G
|
S
|
A
|
L
|
L
|
D
|
T
|
A
|
N
|
2120 |
K
|
R
|
H
|
W
|
E
|
L
|
I
|
Q
|
Q
|
T
|
2130 |
E
|
G
|
G
|
T
|
A
|
W
|
L
|
L
|
Q
|
H
|
2140 |
Y
|
E
|
A
|
Y
|
A
|
S
|
A
|
L
|
A
|
Q
|
2150 |
N
|
M
|
R
|
H
|
T
|
Y
|
L
|
S
|
P
|
F
|
2160 |
T
|
I
|
V
|
T
|
P
|
N
|
I
|
V
|
I
|
S
|
2170 |
V
|
V
|
R
|
L
|
D
|
K
|
G
|
N
|
F
|
A
|
2180 |
G
|
A
|
K
|
L
|
P
|
R
|
Y
|
E
|
A
|
L
|
2190 |
R
|
G
|
E
|
Q
|
P
|
P
|
D
|
L
|
E
|
T
|
2200 |
T
|
V
|
I
|
L
|
P
|
E
|
S
|
V
|
F
|
R
|
2210 |
E
|
T
|
P
|
P
|
V
|
V
|
R
|
P
|
A
|
G
|
2220 |
P
|
G
|
E
|
A
|
Q
|
E
|
P
|
E
|
E
|
L
|
2230 |
A
|
R
|
R
|
Q
|
R
|
R
|
H
|
P
|
E
|
L
|
2240 |
S
|
Q
|
G
|
E
|
A
|
V
|
A
|
S
|
V
|
I
|
2250 |
I
|
Y
|
R
|
T
|
L
|
A
|
G
|
L
|
L
|
P
|
2260 |
H
|
N
|
Y
|
D
|
P
|
D
|
K
|
R
|
S
|
L
|
2270 |
R
|
V
|
P
|
K
|
R
|
P
|
I
|
I
|
N
|
T
|
2280 |
P
|
V
|
V
|
S
|
I
|
S
|
V
|
H
|
D
|
D
|
2290 |
E
|
E
|
L
|
L
|
P
|
R
|
A
|
L
|
D
|
K
|
2300 |
P
|
V
|
T
|
V
|
Q
|
F
|
R
|
L
|
L
|
E
|
2310 |
T
|
E
|
E
|
R
|
T
|
K
|
P
|
I
|
C
|
V
|
2320 |
F
|
W
|
N
|
H
|
S
|
I
|
L
|
V
|
S
|
G
|
2330 |
T
|
G
|
G
|
W
|
S
|
A
|
R
|
G
|
C
|
E
|
2340 |
V
|
V
|
F
|
R
|
N
|
E
|
S
|
H
|
V
|
S
|
2350 |
C
|
Q
|
C
|
N
|
H
|
M
|
T
|
S
|
F
|
A
|
2360 |
V
|
L
|
M
|
D
|
V
|
S
|
R
|
R
|
E
|
N
|
2370 |
TM1 | |||||||||
G
|
E
|
I
|
L
|
P
|
L
|
K
|
T
|
L
|
T
|
2380 |
Y
|
V
|
A
|
L
|
G
|
V
|
T
|
L
|
A
|
A
|
2390 |
L
|
L
|
L
|
T
|
F
|
F
|
F
|
L
|
T
|
L
|
2400 |
ICL1 | TM2 | ||||||||
L
|
R
|
I
|
L
|
R
|
S
|
N
|
Q
|
H
|
G
|
2410 |
I
|
R
|
R
|
N
|
L
|
T
|
A
|
A
|
L
|
G
|
2420 |
L
|
A
|
Q
|
L
|
V
|
F
|
L
|
L
|
G
|
I
|
2430 |
ECL1 | TM3 | ||||||||
N
|
Q
|
A
|
D
|
L
|
P
|
F
|
A
|
C
|
T
|
2440 |
V
|
I
|
A
|
I
|
L
|
L
|
H
|
F
|
L
|
Y
|
2450 |
L
|
C
|
T
|
F
|
S
|
W
|
A
|
L
|
L
|
E
|
2460 |
A
|
L
|
H
|
L
|
Y
|
R
|
A
|
L
|
T
|
E
|
2470 |
ICL2 | TM4 | ||||||||
V
|
R
|
D
|
V
|
N
|
T
|
G
|
P
|
M
|
R
|
2480 |
F
|
Y
|
Y
|
M
|
L
|
G
|
W
|
G
|
V
|
P
|
2490 |
A
|
F
|
I
|
T
|
G
|
L
|
A
|
V
|
G
|
L
|
2500 |
ECL2 | |||||||||
D
|
P
|
E
|
G
|
Y
|
G
|
N
|
P
|
D
|
F
|
2510 |
TM5 | |||||||||
C
|
W
|
L
|
S
|
I
|
Y
|
D
|
T
|
L
|
I
|
2520 |
W
|
S
|
F
|
A
|
G
|
P
|
V
|
A
|
F
|
A
|
2530 |
V
|
S
|
M
|
S
|
V
|
F
|
L
|
Y
|
I
|
L
|
2540 |
A
|
A
|
R
|
A
|
S
|
C
|
A
|
A
|
Q
|
R
|
2550 |
ICL3 | TM6 | ||||||||
Q
|
G
|
F
|
E
|
K
|
K
|
G
|
P
|
V
|
S
|
2560 |
G
|
L
|
Q
|
P
|
S
|
F
|
A
|
V
|
L
|
L
|
2570 |
L
|
L
|
S
|
A
|
T
|
W
|
L
|
L
|
A
|
L
|
2580 |
ECL3 | TM7 | ||||||||
L
|
S
|
V
|
N
|
S
|
D
|
T
|
L
|
L
|
F
|
2590 |
H
|
Y
|
L
|
F
|
A
|
T
|
C
|
N
|
C
|
I
|
2600 |
Q
|
G
|
P
|
F
|
I
|
F
|
L
|
S
|
Y
|
V
|
2610 |
H8 | |||||||||
V
|
L
|
S
|
K
|
E
|
V
|
R
|
K
|
A
|
L
|
2620 |
K
|
L
|
A
|
C
|
S
|
R
|
K
|
P
|
S
|
P
|
2630 |
C-term | |||||||||
D
|
P
|
A
|
L
|
T
|
T
|
K
|
S
|
T
|
L
|
2640 |
T
|
S
|
S
|
Y
|
N
|
C
|
P
|
S
|
P
|
Y
|
2650 |
A
|
D
|
G
|
R
|
L
|
Y
|
Q
|
P
|
Y
|
G
|
2660 |
D
|
S
|
A
|
G
|
S
|
L
|
H
|
S
|
T
|
S
|
2670 |
R
|
S
|
G
|
K
|
S
|
Q
|
P
|
S
|
Y
|
I
|
2680 |
P
|
F
|
L
|
L
|
R
|
E
|
E
|
S
|
A
|
L
|
2690 |
N
|
P
|
G
|
Q
|
G
|
P
|
P
|
G
|
L
|
G
|
2700 |
D
|
P
|
G
|
S
|
L
|
F
|
L
|
E
|
G
|
Q
|
2710 |
D
|
Q
|
Q
|
H
|
D
|
P
|
D
|
T
|
D
|
S
|
2720 |
D
|
S
|
D
|
L
|
S
|
L
|
E
|
D
|
D
|
Q
|
2730 |
S
|
G
|
S
|
Y
|
A
|
S
|
T
|
H
|
S
|
S
|
2740 |
D
|
S
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
2750 |
E
|
E
|
A
|
A
|
F
|
P
|
G
|
E
|
Q
|
G
|
2760 |
W
|
D
|
S
|
L
|
L
|
G
|
P
|
G
|
A
|
E
|
2770 |
R
|
L
|
P
|
L
|
H
|
S
|
T
|
P
|
K
|
D
|
2780 |
G
|
G
|
P
|
G
|
P
|
G
|
K
|
A
|
P
|
W
|
2790 |
P
|
G
|
D
|
F
|
G
|
T
|
T
|
A
|
K
|
E
|
2800 |
S
|
S
|
G
|
N
|
G
|
A
|
P
|
E
|
E
|
R
|
2810 |
L
|
R
|
E
|
N
|
G
|
D
|
A
|
L
|
S
|
R
|
2820 |
E
|
G
|
S
|
L
|
G
|
P
|
L
|
P
|
G
|
S
|
2830 |
S
|
A
|
Q
|
P
|
H
|
K
|
G
|
I
|
L
|
K
|
2840 |
K
|
K
|
C
|
L
|
P
|
T
|
I
|
S
|
E
|
K
|
2850 |
S
|
S
|
L
|
L
|
R
|
L
|
P
|
L
|
E
|
Q
|
2860 |
C
|
T
|
G
|
S
|
S
|
R
|
G
|
S
|
S
|
A
|
2870 |
S
|
E
|
G
|
S
|
R
|
G
|
G
|
P
|
P
|
P
|
2880 |
R
|
P
|
P
|
P
|
R
|
Q
|
S
|
L
|
Q
|
E
|
2890 |
Q
|
L
|
N
|
G
|
V
|
M
|
P
|
I
|
A
|
M
|
2900 |
S
|
I
|
K
|
A
|
G
|
T
|
V
|
D
|
E
|
D
|
2910 |
S
|
S
|
G
|
S
|
E
|
F
|
L
|
F
|
F
|
N
|
2920 |
F
|
L
|
H
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available