CysLT2 receptor (cltr2_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Leukotriene receptors CysLT2 receptor
GENE
CYSLTR2 (CYSLT2, CYSLT2R, PSEC0146)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Cysteinyl leukotriene receptor 2, CysLTR2, G-protein coupled receptor GPCR21, hGPCR21, G-protein coupled receptor HG57, HPN321
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
R
|
K
|
F
|
M
|
S
|
L
|
Q
|
P
|
10 |
S
|
I
|
S
|
V
|
S
|
E
|
M
|
E
|
P
|
N
|
20 |
G
|
T
|
F
|
S
|
N
|
N
|
N
|
S
|
R
|
N
|
30 |
TM1 | |||||||||
C
|
T
|
I
|
E
|
N
|
F
|
K
|
R
|
E
|
F
|
40 |
F
|
P
|
I
|
V
|
Y
|
L
|
I
|
I
|
F
|
F
|
50 |
W
|
G
|
V
|
L
|
G
|
N
|
G
|
L
|
S
|
I
|
60 |
ICL1 | |||||||||
Y
|
V
|
F
|
L
|
Q
|
P
|
Y
|
K
|
K
|
S
|
70 |
TM2 | |||||||||
T
|
S
|
V
|
N
|
V
|
F
|
M
|
L
|
N
|
L
|
80 |
A
|
I
|
S
|
D
|
L
|
L
|
F
|
I
|
S
|
T
|
90 |
L
|
P
|
F
|
R
|
A
|
D
|
Y
|
Y
|
L
|
R
|
100 |
ECL1 | TM3 | ||||||||
G
|
S
|
N
|
W
|
I
|
F
|
G
|
D
|
L
|
A
|
110 |
C
|
R
|
I
|
M
|
S
|
Y
|
S
|
L
|
Y
|
V
|
120 |
N
|
M
|
Y
|
S
|
S
|
I
|
Y
|
F
|
L
|
T
|
130 |
V
|
L
|
S
|
V
|
V
|
R
|
F
|
L
|
A
|
M
|
140 |
ICL2 | |||||||||
V
|
H
|
P
|
F
|
R
|
L
|
L
|
H
|
V
|
T
|
150 |
TM4 | |||||||||
S
|
I
|
R
|
S
|
A
|
W
|
I
|
L
|
C
|
G
|
160 |
I
|
I
|
W
|
I
|
L
|
I
|
M
|
A
|
S
|
S
|
170 |
ECL2 | |||||||||
I
|
M
|
L
|
L
|
D
|
S
|
G
|
S
|
E
|
Q
|
180 |
N
|
G
|
S
|
V
|
T
|
S
|
C
|
L
|
E
|
L
|
190 |
TM5 | |||||||||
N
|
L
|
Y
|
K
|
I
|
A
|
K
|
L
|
Q
|
T
|
200 |
M
|
N
|
Y
|
I
|
A
|
L
|
V
|
V
|
G
|
C
|
210 |
L
|
L
|
P
|
F
|
F
|
T
|
L
|
S
|
I
|
C
|
220 |
Y
|
L
|
L
|
I
|
I
|
R
|
V
|
L
|
L
|
K
|
230 |
ICL3 | TM6 | ||||||||
V
|
E
|
V
|
P
|
E
|
S
|
G
|
L
|
R
|
V
|
240 |
S
|
H
|
R
|
K
|
A
|
L
|
T
|
T
|
I
|
I
|
250 |
I
|
T
|
L
|
I
|
I
|
F
|
F
|
L
|
C
|
F
|
260 |
L
|
P
|
Y
|
H
|
T
|
L
|
R
|
T
|
V
|
H
|
270 |
ECL3 | |||||||||
L
|
T
|
T
|
W
|
K
|
V
|
G
|
L
|
C
|
K
|
280 |
TM7 | |||||||||
D
|
R
|
L
|
H
|
K
|
A
|
L
|
V
|
I
|
T
|
290 |
L
|
A
|
L
|
A
|
A
|
A
|
N
|
A
|
C
|
F
|
300 |
H8 | |||||||||
N
|
P
|
L
|
L
|
Y
|
Y
|
F
|
A
|
G
|
E
|
310 |
N
|
F
|
K
|
D
|
R
|
L
|
K
|
S
|
A
|
L
|
320 |
C-term | |||||||||
R
|
K
|
G
|
H
|
P
|
Q
|
K
|
A
|
K
|
T
|
330 |
K
|
C
|
V
|
F
|
P
|
V
|
S
|
V
|
W
|
L
|
340 |
R
|
K
|
E
|
T
|
R
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
LTE4, LTD4, LTC4
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page