D5 receptor (drd5_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Dopamine receptors D5 receptor
GENE
DRD5 (DRD1B, DRD1L2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
D(1B) dopamine receptor, D(5) dopamine receptor, D1beta dopamine receptor, Dopamine D5 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
P
|
P
|
G
|
S
|
N
|
G
|
T
|
A
|
10 |
Y
|
P
|
G
|
Q
|
F
|
A
|
L
|
Y
|
Q
|
Q
|
20 |
L
|
A
|
Q
|
G
|
N
|
A
|
V
|
G
|
G
|
S
|
30 |
TM1 | |||||||||
A
|
G
|
A
|
P
|
P
|
L
|
G
|
P
|
S
|
Q
|
40 |
V
|
V
|
T
|
A
|
C
|
L
|
L
|
T
|
L
|
L
|
50 |
I
|
I
|
W
|
T
|
L
|
L
|
G
|
N
|
V
|
L
|
60 |
V
|
C
|
A
|
A
|
I
|
V
|
R
|
S
|
R
|
H
|
70 |
ICL1 | TM2 | ||||||||
L
|
R
|
A
|
N
|
M
|
T
|
N
|
V
|
F
|
I
|
80 |
V
|
S
|
L
|
A
|
V
|
S
|
D
|
L
|
F
|
V
|
90 |
A
|
L
|
L
|
V
|
M
|
P
|
W
|
K
|
A
|
V
|
100 |
ECL1 | |||||||||
A
|
E
|
V
|
A
|
G
|
Y
|
W
|
P
|
F
|
G
|
110 |
TM3 | |||||||||
A
|
F
|
C
|
D
|
V
|
W
|
V
|
A
|
F
|
D
|
120 |
I
|
M
|
C
|
S
|
T
|
A
|
S
|
I
|
L
|
N
|
130 |
L
|
C
|
V
|
I
|
S
|
V
|
D
|
R
|
Y
|
W
|
140 |
ICL2 | |||||||||
A
|
I
|
S
|
R
|
P
|
F
|
R
|
Y
|
K
|
R
|
150 |
TM4 | |||||||||
K
|
M
|
T
|
Q
|
R
|
M
|
A
|
L
|
V
|
M
|
160 |
V
|
G
|
L
|
A
|
W
|
T
|
L
|
S
|
I
|
L
|
170 |
I
|
S
|
F
|
I
|
P
|
V
|
Q
|
L
|
N
|
W
|
180 |
ECL2 | |||||||||
H
|
R
|
D
|
Q
|
A
|
A
|
S
|
W
|
G
|
G
|
190 |
L
|
D
|
L
|
P
|
N
|
N
|
L
|
A
|
N
|
W
|
200 |
T
|
P
|
W
|
E
|
E
|
D
|
F
|
W
|
E
|
P
|
210 |
D
|
V
|
N
|
A
|
E
|
N
|
C
|
D
|
S
|
S
|
220 |
TM5 | |||||||||
L
|
N
|
R
|
T
|
Y
|
A
|
I
|
S
|
S
|
S
|
230 |
L
|
I
|
S
|
F
|
Y
|
I
|
P
|
V
|
A
|
I
|
240 |
M
|
I
|
V
|
T
|
Y
|
T
|
R
|
I
|
Y
|
R
|
250 |
I
|
A
|
Q
|
V
|
Q
|
I
|
R
|
R
|
I
|
S
|
260 |
S
|
L
|
E
|
R
|
A
|
A
|
E
|
H
|
A
|
Q
|
270 |
ICL3 | |||||||||
S
|
C
|
R
|
S
|
S
|
A
|
A
|
C
|
A
|
P
|
280 |
TM6 | |||||||||
D
|
T
|
S
|
L
|
R
|
A
|
S
|
I
|
K
|
K
|
290 |
E
|
T
|
K
|
V
|
L
|
K
|
T
|
L
|
S
|
V
|
300 |
I
|
M
|
G
|
V
|
F
|
V
|
C
|
C
|
W
|
L
|
310 |
P
|
F
|
F
|
I
|
L
|
N
|
C
|
M
|
V
|
P
|
320 |
ECL3 | |||||||||
F
|
C
|
S
|
G
|
H
|
P
|
E
|
G
|
P
|
P
|
330 |
TM7 | |||||||||
A
|
G
|
F
|
P
|
C
|
V
|
S
|
E
|
T
|
T
|
340 |
F
|
D
|
V
|
F
|
V
|
W
|
F
|
G
|
W
|
A
|
350 |
N
|
S
|
S
|
L
|
N
|
P
|
V
|
I
|
Y
|
A
|
360 |
H8 | |||||||||
F
|
N
|
A
|
D
|
F
|
Q
|
K
|
V
|
F
|
A
|
370 |
C-term | |||||||||
Q
|
L
|
L
|
G
|
C
|
S
|
H
|
F
|
C
|
S
|
380 |
R
|
T
|
P
|
V
|
E
|
T
|
V
|
N
|
I
|
S
|
390 |
N
|
E
|
L
|
I
|
S
|
Y
|
N
|
Q
|
D
|
I
|
400 |
V
|
F
|
H
|
K
|
E
|
I
|
A
|
A
|
A
|
Y
|
410 |
I
|
H
|
M
|
M
|
P
|
N
|
A
|
V
|
T
|
P
|
420 |
G
|
N
|
R
|
E
|
V
|
D
|
N
|
D
|
E
|
E
|
430 |
E
|
G
|
P
|
F
|
D
|
R
|
M
|
F
|
Q
|
I
|
440 |
Y
|
Q
|
T
|
S
|
P
|
D
|
G
|
D
|
P
|
V
|
450 |
A
|
E
|
S
|
V
|
W
|
E
|
L
|
D
|
C
|
E
|
460 |
G
|
E
|
I
|
S
|
L
|
D
|
K
|
I
|
T
|
P
|
470 |
F
|
T
|
P
|
N
|
G
|
F
|
H
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
L-NOREPINEPHRINE, 5-hydroxytryptamine, noradrenaline, (-)-noradrenaline, dopamine
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8IRV