GPR4 (e7fel0_danre)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR4
GENE
gpr4 ()
ORGANISM
Zebrafish (Danio rerio)
ALT. NAMES
G-protein coupled receptor 4
SOURCE
TREMBL
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
L
|
R
|
G
|
S
|
E
|
T
|
M
|
10 |
C
|
N
|
I
|
T
|
T
|
S
|
C
|
N
|
V
|
D
|
20 |
TM1 | |||||||||
S
|
N
|
I
|
D
|
Q
|
F
|
F
|
Q
|
P
|
T
|
30 |
L
|
Y
|
I
|
I
|
V
|
I
|
V
|
L
|
G
|
F
|
40 |
P
|
T
|
N
|
C
|
M
|
A
|
L
|
W
|
A
|
A
|
50 |
ICL1 | |||||||||
Y
|
M
|
Q
|
V
|
K
|
Q
|
K
|
N
|
E
|
L
|
60 |
TM2 | |||||||||
G
|
I
|
Y
|
L
|
M
|
N
|
L
|
S
|
I
|
A
|
70 |
D
|
L
|
L
|
Y
|
I
|
T
|
T
|
L
|
P
|
L
|
80 |
W
|
I
|
D
|
Y
|
F
|
V
|
H
|
H
|
D
|
N
|
90 |
ECL1 | TM3 | ||||||||
W
|
I
|
H
|
G
|
Q
|
V
|
S
|
C
|
K
|
L
|
100 |
F
|
G
|
F
|
I
|
F
|
Y
|
T
|
N
|
I
|
Y
|
110 |
V
|
S
|
I
|
A
|
F
|
L
|
C
|
C
|
I
|
S
|
120 |
V
|
D
|
R
|
Y
|
L
|
A
|
V
|
A
|
H
|
P
|
130 |
ICL2 | TM4 | ||||||||
L
|
K
|
F
|
A
|
K
|
V
|
R
|
R
|
V
|
K
|
140 |
T
|
A
|
L
|
L
|
V
|
S
|
A
|
I
|
V
|
W
|
150 |
L
|
T
|
E
|
I
|
V
|
A
|
N
|
S
|
A
|
P
|
160 |
ECL2 | |||||||||
L
|
F
|
H
|
D
|
E
|
L
|
F
|
Q
|
D
|
R
|
170 |
F
|
N
|
H
|
T
|
F
|
C
|
F
|
E
|
K
|
Y
|
180 |
P
|
M
|
E
|
P
|
W
|
V
|
A
|
G
|
M
|
N
|
190 |
TM5 | |||||||||
L
|
Y
|
R
|
T
|
F
|
L
|
G
|
F
|
L
|
A
|
200 |
P
|
W
|
G
|
I
|
M
|
L
|
A
|
A
|
Y
|
R
|
210 |
G
|
I
|
L
|
R
|
A
|
V
|
R
|
G
|
N
|
V
|
220 |
ICL3 | TM6 | ||||||||
S
|
T
|
E
|
R
|
Q
|
E
|
K
|
A
|
K
|
I
|
230 |
K
|
R
|
L
|
A
|
L
|
S
|
L
|
I
|
L
|
I
|
240 |
V
|
L
|
L
|
C
|
F
|
A
|
P
|
Y
|
H
|
V
|
250 |
L
|
L
|
L
|
W
|
R
|
S
|
V
|
L
|
F
|
L
|
260 |
ECL3 | TM7 | ||||||||
I
|
N
|
P
|
C
|
D
|
C
|
G
|
G
|
E
|
E
|
270 |
N
|
L
|
F
|
G
|
A
|
Y
|
H
|
V
|
T
|
L
|
280 |
A
|
L
|
T
|
S
|
L
|
N
|
C
|
V
|
A
|
D
|
290 |
H8 | |||||||||
P
|
I
|
L
|
Y
|
C
|
F
|
V
|
N
|
E
|
G
|
300 |
A
|
R
|
H
|
D
|
V
|
G
|
R
|
A
|
L
|
A
|
310 |
T
|
L
|
L
|
G
|
L
|
F
|
Q
|
R
|
G
|
K
|
320 |
C-term | |||||||||
S
|
P
|
E
|
T
|
L
|
M
|
G
|
A
|
S
|
I
|
330 |
T
|
V
|
E
|
T
|
P
|
L
|
A
|
V
|
K
|
K
|
340 |
P
|
D
|
F
|
Y
|
S
|
E
|
V
|
K
|
T
|
N
|
350 |
A
|
Y
|
K
|
N
|
D
|
I
|
E
|
V
|
L
|
K
|
360 |
D
|
E
|
C
|
L
|
Q
|
M
|
T
|
I
|
L
|
S
|
370 |
V
|
K
|
K
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8ZFJ