GPR137 (g137a_human)
FAMILY
Other GPCRs Orphan receptors Other GPCR orphans GPR137
GENE
GPR137 (C11orf4, GPR137A, TM7SF1L1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Integral membrane protein GPR137, Transmembrane 7 superfamily member 1-like 1 protein
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
S
|
N
|
L
|
S
|
G
|
L
|
V
|
P
|
10 |
A
|
A
|
G
|
L
|
V
|
P
|
A
|
L
|
P
|
P
|
20 |
TM1 | |||||||||
A
|
V
|
T
|
L
|
G
|
L
|
T
|
A
|
A
|
Y
|
30 |
T
|
T
|
L
|
Y
|
A
|
L
|
L
|
F
|
F
|
S
|
40 |
V
|
Y
|
A
|
Q
|
L
|
W
|
L
|
V
|
L
|
L
|
50 |
ICL1 | TM2 | ||||||||
Y
|
G
|
H
|
K
|
R
|
L
|
S
|
Y
|
Q
|
T
|
60 |
V
|
F
|
L
|
A
|
L
|
C
|
L
|
L
|
W
|
A
|
70 |
A
|
L
|
R
|
T
|
T
|
L
|
F
|
S
|
F
|
Y
|
80 |
ECL1 | |||||||||
F
|
R
|
D
|
T
|
P
|
R
|
A
|
N
|
R
|
L
|
90 |
TM3 | |||||||||
G
|
P
|
L
|
P
|
F
|
W
|
L
|
L
|
Y
|
C
|
100 |
C
|
P
|
V
|
C
|
L
|
Q
|
F
|
F
|
T
|
L
|
110 |
T
|
L
|
M
|
N
|
L
|
Y
|
F
|
A
|
Q
|
V
|
120 |
V
|
F
|
K
|
A
|
K
|
V
|
K
|
R
|
R
|
P
|
130 |
TM4 | |||||||||
E
|
M
|
S
|
R
|
G
|
L
|
L
|
A
|
V
|
R
|
140 |
G
|
A
|
F
|
V
|
G
|
A
|
S
|
L
|
L
|
F
|
150 |
L
|
L
|
V
|
N
|
V
|
L
|
C
|
A
|
V
|
L
|
160 |
ECL2 | TM5 | |||||||||
S
|
H
|
R
|
R
|
R
|
A
|
Q
|
P
|
W
|
A
|
|
170 |
L
|
L
|
L
|
V
|
R
|
V
|
L
|
V
|
S
|
D
|
180 |
S
|
L
|
F
|
V
|
I
|
C
|
A
|
L
|
S
|
L
|
190 |
A
|
A
|
C
|
L
|
C
|
L
|
V
|
A
|
R
|
R
|
200 |
ICL3 | |||||||||
A
|
P
|
S
|
T
|
S
|
I
|
Y
|
L
|
E
|
A
|
210 |
TM6 | |||||||||
K
|
G
|
T
|
S
|
V
|
C
|
Q
|
A
|
A
|
A
|
220 |
M
|
G
|
G
|
A
|
M
|
V
|
L
|
L
|
Y
|
A
|
230 |
S
|
R
|
A
|
C
|
Y
|
N
|
L
|
T
|
A
|
L
|
240 |
ECL3 | |||||||||
A
|
L
|
A
|
P
|
Q
|
S
|
R
|
L
|
D
|
T
|
250 |
F
|
D
|
Y
|
D
|
W
|
Y
|
N
|
V
|
S
|
D
|
260 |
Q
|
A
|
D
|
L
|
V
|
N
|
D
|
L
|
G
|
N
|
270 |
TM7 | |||||||||
K
|
G
|
Y
|
L
|
V
|
F
|
G
|
L
|
I
|
L
|
280 |
F
|
V
|
W
|
E
|
L
|
L
|
P
|
T
|
T
|
L
|
290 |
L
|
V
|
G
|
F
|
F
|
R
|
V
|
H
|
R
|
P
|
300 |
C-term | |||||||||
P
|
Q
|
D
|
L
|
S
|
T
|
S
|
H
|
I
|
L
|
310 |
N
|
G
|
Q
|
V
|
F
|
A
|
S
|
R
|
S
|
Y
|
320 |
F
|
F
|
D
|
R
|
A
|
G
|
H
|
C
|
E
|
D
|
330 |
E
|
G
|
C
|
S
|
W
|
E
|
H
|
S
|
R
|
G
|
340 |
E
|
S
|
T
|
R
|
C
|
Q
|
D
|
Q
|
A
|
A
|
350 |
T
|
T
|
T
|
V
|
S
|
T
|
P
|
P
|
H
|
R
|
360 |
R
|
D
|
P
|
P
|
P
|
S
|
P
|
T
|
E
|
Y
|
370 |
P
|
G
|
P
|
S
|
P
|
P
|
H
|
P
|
R
|
P
|
380 |
L
|
C
|
Q
|
V
|
C
|
L
|
P
|
L
|
L
|
A
|
390 |
Q
|
D
|
P
|
G
|
G
|
R
|
G
|
Y
|
P
|
L
|
400 |
L
|
W
|
P
|
A
|
P
|
C
|
C
|
S
|
C
|
H
|
410 |
S
|
E
|
L
|
V
|
P
|
S
|
P
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available