GPR141 (gp141_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR141
GENE
GPR141 (PGR13)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 141, G-protein coupled receptor PGR13
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
P
|
G
|
H
|
N
|
T
|
S
|
R
|
N
|
S
|
10 |
TM1 | |||||||||
S
|
C
|
D
|
P
|
I
|
V
|
T
|
P
|
H
|
L
|
20 |
I
|
S
|
L
|
Y
|
F
|
I
|
V
|
L
|
I
|
G
|
30 |
G
|
L
|
V
|
G
|
V
|
I
|
S
|
I
|
L
|
F
|
40 |
ICL1 | |||||||||
L
|
L
|
V
|
K
|
M
|
N
|
T
|
R
|
S
|
V
|
50 |
TM2 | |||||||||
T
|
T
|
M
|
A
|
V
|
I
|
N
|
L
|
V
|
V
|
60 |
V
|
H
|
S
|
V
|
F
|
L
|
L
|
T
|
V
|
P
|
70 |
F
|
R
|
L
|
T
|
Y
|
L
|
I
|
K
|
K
|
T
|
80 |
ECL1 | TM3 | ||||||||
W
|
M
|
F
|
G
|
L
|
P
|
F
|
C
|
K
|
F
|
90 |
V
|
S
|
A
|
M
|
L
|
H
|
I
|
H
|
M
|
Y
|
100 |
L
|
T
|
F
|
L
|
F
|
Y
|
V
|
V
|
I
|
L
|
110 |
V
|
T
|
R
|
Y
|
L
|
I
|
F
|
F
|
K
|
C
|
120 |
ICL2 | TM4 | ||||||||
K
|
D
|
K
|
V
|
E
|
F
|
Y
|
R
|
K
|
L
|
130 |
H
|
A
|
V
|
A
|
A
|
S
|
A
|
G
|
M
|
W
|
140 |
T
|
L
|
V
|
I
|
V
|
I
|
V
|
V
|
P
|
L
|
150 |
ECL2 | |||||||||
V
|
V
|
S
|
R
|
Y
|
G
|
I
|
H
|
E
|
E
|
160 |
Y
|
N
|
E
|
E
|
H
|
C
|
F
|
K
|
F
|
H
|
170 |
TM5 | |||||||||
K
|
E
|
L
|
A
|
Y
|
T
|
Y
|
V
|
K
|
I
|
180 |
I
|
N
|
Y
|
M
|
I
|
V
|
I
|
F
|
V
|
I
|
190 |
A
|
V
|
A
|
V
|
I
|
L
|
L
|
V
|
F
|
Q
|
200 |
V
|
F
|
I
|
I
|
M
|
L
|
M
|
V
|
Q
|
K
|
210 |
ICL3 | |||||||||
L
|
R
|
H
|
S
|
L
|
L
|
S
|
H
|
Q
|
E
|
220 |
TM6 | |||||||||
F
|
W
|
A
|
Q
|
L
|
K
|
N
|
L
|
F
|
F
|
230 |
I
|
G
|
V
|
I
|
L
|
V
|
C
|
F
|
L
|
P
|
240 |
Y
|
Q
|
F
|
F
|
R
|
I
|
Y
|
Y
|
L
|
N
|
250 |
ECL3 | TM7 | ||||||||
V
|
V
|
T
|
H
|
S
|
N
|
A
|
C
|
N
|
S
|
260 |
K
|
V
|
A
|
F
|
Y
|
N
|
E
|
I
|
F
|
L
|
270 |
S
|
V
|
T
|
A
|
I
|
S
|
C
|
Y
|
D
|
L
|
280 |
ICL4 | H8 | ||||||||||
L
|
L
|
F
|
V
|
F
|
G
|
G
|
S
|
H
|
W
|
||
290 |
F
|
K
|
Q
|
K
|
I
|
I
|
G
|
L
|
W
|
N
|
300 |
C-term | |||||
C
|
V
|
L
|
C
|
R
|
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available