GPR27 (gpr27_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR27
GENE
GPR27 (SREB1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 27, Super conserved receptor expressed in brain 1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
N
|
A
|
S
|
E
|
P
|
G
|
G
|
S
|
10 |
TM1 | |||||||||
G
|
G
|
G
|
E
|
A
|
A
|
A
|
L
|
G
|
L
|
20 |
K
|
L
|
A
|
T
|
L
|
S
|
L
|
L
|
L
|
C
|
30 |
V
|
S
|
L
|
A
|
G
|
N
|
V
|
L
|
F
|
A
|
40 |
ICL1 | |||||||||
L
|
L
|
I
|
V
|
R
|
E
|
R
|
S
|
L
|
H
|
50 |
TM2 | |||||||||
R
|
A
|
P
|
Y
|
Y
|
L
|
L
|
L
|
D
|
L
|
60 |
C
|
L
|
A
|
D
|
G
|
L
|
R
|
A
|
L
|
A
|
70 |
C
|
L
|
P
|
A
|
V
|
M
|
L
|
A
|
A
|
R
|
80 |
ECL1 | TM3 | ||||||||
R
|
A
|
A
|
A
|
A
|
A
|
G
|
A
|
P
|
P
|
90 |
G
|
A
|
L
|
G
|
C
|
K
|
L
|
L
|
A
|
F
|
100 |
L
|
A
|
A
|
L
|
F
|
C
|
F
|
H
|
A
|
A
|
110 |
F
|
L
|
L
|
L
|
G
|
V
|
G
|
V
|
T
|
R
|
120 |
ICL2 | |||||||||
Y
|
L
|
A
|
I
|
A
|
H
|
H
|
R
|
F
|
Y
|
130 |
TM4 | |||||||||
A
|
E
|
R
|
L
|
A
|
G
|
W
|
P
|
C
|
A
|
140 |
A
|
M
|
L
|
V
|
C
|
A
|
A
|
W
|
A
|
L
|
150 |
A
|
L
|
A
|
A
|
A
|
F
|
P
|
P
|
V
|
L
|
160 |
ECL2 | |||||||||
D
|
G
|
G
|
G
|
D
|
D
|
E
|
D
|
A
|
P
|
170 |
TM5 | |||||||||
C
|
A
|
L
|
E
|
Q
|
R
|
P
|
D
|
G
|
A
|
180 |
P
|
G
|
A
|
L
|
G
|
F
|
L
|
L
|
L
|
L
|
190 |
A
|
V
|
V
|
V
|
G
|
A
|
T
|
H
|
L
|
V
|
200 |
Y
|
L
|
R
|
L
|
L
|
F
|
F
|
I
|
H
|
D
|
210 |
ICL3 | |||||||||
R
|
R
|
K
|
M
|
R
|
P
|
A
|
R
|
L
|
V
|
220 |
P
|
A
|
V
|
S
|
H
|
D
|
W
|
T
|
F
|
H
|
230 |
G
|
P
|
G
|
A
|
T
|
G
|
Q
|
A
|
A
|
A
|
240 |
N
|
W
|
T
|
A
|
G
|
F
|
G
|
R
|
G
|
P
|
250 |
T
|
P
|
P
|
A
|
L
|
V
|
G
|
I
|
R
|
P
|
260 |
A
|
G
|
P
|
G
|
R
|
G
|
A
|
R
|
R
|
L
|
270 |
TM6 | |||||||||
L
|
V
|
L
|
E
|
E
|
F
|
K
|
T
|
E
|
K
|
280 |
R
|
L
|
C
|
K
|
M
|
F
|
Y
|
A
|
V
|
T
|
290 |
L
|
L
|
F
|
L
|
L
|
L
|
W
|
G
|
P
|
Y
|
300 |
V
|
V
|
A
|
S
|
Y
|
L
|
R
|
V
|
L
|
V
|
310 |
ECL3 | TM7 | ||||||||
R
|
P
|
G
|
A
|
V
|
P
|
Q
|
A
|
Y
|
L
|
320 |
T
|
A
|
S
|
V
|
W
|
L
|
T
|
F
|
A
|
Q
|
330 |
A
|
G
|
I
|
N
|
P
|
V
|
V
|
C
|
F
|
L
|
340 |
H8 | |||||||||
F
|
N
|
R
|
E
|
L
|
R
|
D
|
C
|
F
|
R
|
350 |
A
|
Q
|
F
|
P
|
C
|
C
|
Q
|
S
|
P
|
R
|
360 |
C-term | |||||||||
T
|
T
|
Q
|
A
|
T
|
H
|
P
|
C
|
D
|
L
|
370 |
K
|
G
|
I
|
G
|
L
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available