MRGPRE (mrgre_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRE

GENE

MRGPRE (GPR167, MRGE)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Mas-related G-protein coupled receptor member E, G-protein coupled receptor 167

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
M
E
P
R
E
A
G
Q
H
10
                   
V
G
A
A
N
G
A
Q
E
D
20
      TM1        
V
A
F
N
L
I
I
L
S
L
30
                   
T
E
G
L
G
L
G
G
L
L
40
                   
G
N
G
A
V
L
W
L
L
S
50
      ICL1 TM2
S
N
V
Y
R
N
P
F
A
I
60
                   
Y
L
L
D
V
A
C
A
D
L
70
                   
I
F
L
G
C
H
M
V
A
I
80
          ECL1  
V
P
D
L
L
Q
G
R
L
D
90
  TM3            
F
P
G
F
V
Q
T
S
L
A
100
                   
T
L
R
F
F
C
Y
I
V
G
110
                   
L
S
L
L
A
A
V
S
V
E
120
                   
Q
C
L
A
A
L
F
P
A
W
130
ICL2   TM4    
Y
S
C
R
R
P
R
H
L
T
140
                   
T
C
V
C
A
L
T
W
A
L
150
                   
C
L
L
L
H
L
L
L
S
G
160
    ECL2        
A
C
T
Q
F
F
G
E
P
S
170
  TM5            
R
H
L
C
R
T
L
W
L
V
180
                   
A
A
V
L
L
A
L
L
C
C
190
                   
T
M
C
G
A
S
L
M
L
L
200
                   
L
R
V
E
R
G
P
Q
R
P
210
ICL3 TM6      
P
P
R
G
F
P
G
L
I
L
220
                   
L
T
V
L
L
F
L
F
C
G
230
                   
L
P
F
G
I
Y
W
L
S
R
240
      ECL3 TM7
N
L
L
W
Y
I
P
H
Y
F
250
                   
Y
H
F
S
F
L
M
A
A
V
260
                   
H
C
A
A
K
P
V
V
Y
F
270
    H8            
C
L
G
S
A
Q
G
R
R
L
280
                   
P
L
R
L
V
L
Q
R
A
L
290
C-term        
G
D
E
A
E
L
G
A
V
R
300
                   
E
T
S
R
R
G
L
V
D
I
310
   
A
A

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 Y R ICL1ECL1 Q G R L D F ECL1ICL2 P A W Y S C R R ICL2ECL2 T Q F F G E P S R ECL2ICL3 R P P ICL3ECL3 W Y I P ECL3N-term M M E P R E A G Q H V G A A N G A Q E D V A F N-termC-term R A L G D E A E L G A V R E T S R R G L V D I A A C-term N L I I L S L T E G L G L G G L L G N G A V L W L L S S N V N P F A I Y L L D V A C A D L I F L G C H M V A I V P D L L P G F V Q T S L A T L R F F C Y I V G L S L L A A V S V E Q C L A A L F P R H L T T C V C A L T W A L C L L L H L L L S G A C H L C R T L W L V A A V L L A L L C C T M C G A S L M L L L R V E R G P Q P R G F P G L I L L T V L L F L F C G L P F G I Y W L S R N L L H Y F Y H F S F L M A A V H C A A K P V V Y F C L G S A L P L Q Q G R R R L V L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L L G G L G L G E T L S L I I L N 1 L D V A C A D L I F L G C H M V A I V P 2 A A L L S L G V I Y C F F R L T A L S T 3 T T C V C A L T W A L C L L L H L L L S 4 M L S A G C M T C C L L A L L V A A V L 5 L L T V L L F L F C G L P F G I Y W L S 6 V P K A A C H V A A M L F S F H Y F Y 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

mrgre_human inactive,

mrgre_human active

STRUCTURES

No structures available