MRGPRF (mrgrf_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRF

GENE

MRGPRF (GPR140, GPR168, MRGF, PSEC0142)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Mas-related G-protein coupled receptor member F, Mas-related gene F protein, G-protein coupled receptor 140, G-protein coupled receptor 168

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
G
N
C
S
W
E
A
H
10
                   
P
G
N
R
N
K
M
C
P
G
20
                   
L
S
E
A
P
E
L
Y
S
R
30
                   
G
F
L
T
I
E
Q
I
A
M
40
      TM1        
L
P
P
P
A
V
M
N
Y
I
50
                   
F
L
L
L
C
L
C
G
L
V
60
                   
G
N
G
L
V
L
W
F
F
G
70
      ICL1 TM2
F
S
I
K
R
N
P
F
S
I
80
                   
Y
F
L
H
L
A
S
A
D
V
90
                   
G
Y
L
F
S
K
A
V
F
S
100
            ECL1
I
L
N
T
G
G
F
L
G
T
110
  TM3            
F
A
D
Y
I
R
S
V
C
R
120
                   
V
L
G
L
C
M
F
L
T
G
130
                   
V
S
L
L
P
A
V
S
A
E
140
                   
R
C
A
S
V
I
F
P
A
W
150
ICL2   TM4    
Y
W
R
R
R
P
K
R
L
S
160
                   
A
V
V
C
A
L
L
W
V
L
170
                   
S
L
L
V
T
C
L
H
N
Y
180
    ECL2        
F
C
V
F
L
G
R
G
A
P
190
    TM5          
G
A
A
C
R
H
M
D
I
F
200
                   
L
G
I
L
L
F
L
L
C
C
210
                   
P
L
M
V
L
P
C
L
A
L
220
                   
I
L
H
V
E
C
R
A
R
R
230
ICL3 TM6      
R
Q
R
S
A
K
L
N
H
V
240
                   
I
L
A
M
V
S
V
F
L
V
250
                   
S
S
I
Y
L
G
I
D
W
F
260
          ECL3  
L
F
W
V
F
Q
I
P
A
P
270
TM7              
F
P
E
Y
V
T
D
L
C
I
280
                   
C
I
N
S
S
A
K
P
I
V
290
        H8        
Y
F
L
A
G
R
D
K
S
Q
300
                   
R
L
W
E
P
L
R
V
V
F
310
C-term        
Q
R
A
L
R
D
G
A
E
L
320
                   
G
E
A
G
G
S
T
P
N
T
330
                   
V
T
M
E
M
Q
C
P
P
G
340
     
N
A
S

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K R ICL1ECL1 F L G T F ECL1ICL2 P A W Y W R R R ICL2ECL2 V F L G R G A P G A ECL2ICL3 R R Q R ICL3ECL3 Q I P A ECL3N-term M A G N C S W E A H P G N R N K M C P G L S E A P E L Y S R G F L T I E Q I A M L P P N-termC-term Q R A L R D G A E L G E A G G S T P N T V T M E M Q C P P G N A S C-term P A V M N Y I F L L L C L C G L V G N G L V L W F F G F S I N P F S I Y F L H L A S A D V G Y L F S K A V F S I L N T G G A D Y I R S V C R V L G L C M F L T G V S L L P A V S A E R C A S V I F P K R L S A V V C A L L W V L S L L V T C L H N Y F C A C R H M D I F L G I L L F L L C C P L M V L P C L A L I L H V E C R A R S A K L N H V I L A M V S V F L V S S I Y L G I D W F L F W V F P F P E Y V T D L C I C I N S S A K P I V Y F L A G R D L W E V F K S Q R P L R V
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V L G C L C L L L F I Y N M V A P 1 L H L A S A D V G Y L F S K A V F S I L 2 A P L L S V G T L F M C L G L V R C V S 3 S A V V C A L L W V L S L L V T C L H N 4 A L C P L V M L P C C L L F L L I G L F I 5 L A M V S V F L V S S I Y L G I D W F L 6 I P K A S S N I C I C L D T V Y E P F 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

2 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

mrgrf_human inactive,

mrgrf_human active

STRUCTURES

No structures available