MRGPRF (mrgrf_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRF
GENE
MRGPRF (GPR140, GPR168, MRGF, PSEC0142)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Mas-related G-protein coupled receptor member F, Mas-related gene F protein, G-protein coupled receptor 140, G-protein coupled receptor 168
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
G
|
N
|
C
|
S
|
W
|
E
|
A
|
H
|
10 |
P
|
G
|
N
|
R
|
N
|
K
|
M
|
C
|
P
|
G
|
20 |
L
|
S
|
E
|
A
|
P
|
E
|
L
|
Y
|
S
|
R
|
30 |
G
|
F
|
L
|
T
|
I
|
E
|
Q
|
I
|
A
|
M
|
40 |
TM1 | |||||||||
L
|
P
|
P
|
P
|
A
|
V
|
M
|
N
|
Y
|
I
|
50 |
F
|
L
|
L
|
L
|
C
|
L
|
C
|
G
|
L
|
V
|
60 |
G
|
N
|
G
|
L
|
V
|
L
|
W
|
F
|
F
|
G
|
70 |
ICL1 | TM2 | ||||||||
F
|
S
|
I
|
K
|
R
|
N
|
P
|
F
|
S
|
I
|
80 |
Y
|
F
|
L
|
H
|
L
|
A
|
S
|
A
|
D
|
V
|
90 |
G
|
Y
|
L
|
F
|
S
|
K
|
A
|
V
|
F
|
S
|
100 |
ECL1 | |||||||||
I
|
L
|
N
|
T
|
G
|
G
|
F
|
L
|
G
|
T
|
110 |
TM3 | |||||||||
F
|
A
|
D
|
Y
|
I
|
R
|
S
|
V
|
C
|
R
|
120 |
V
|
L
|
G
|
L
|
C
|
M
|
F
|
L
|
T
|
G
|
130 |
V
|
S
|
L
|
L
|
P
|
A
|
V
|
S
|
A
|
E
|
140 |
R
|
C
|
A
|
S
|
V
|
I
|
F
|
P
|
A
|
W
|
150 |
ICL2 | TM4 | ||||||||
Y
|
W
|
R
|
R
|
R
|
P
|
K
|
R
|
L
|
S
|
160 |
A
|
V
|
V
|
C
|
A
|
L
|
L
|
W
|
V
|
L
|
170 |
S
|
L
|
L
|
V
|
T
|
C
|
L
|
H
|
N
|
Y
|
180 |
ECL2 | |||||||||
F
|
C
|
V
|
F
|
L
|
G
|
R
|
G
|
A
|
P
|
190 |
TM5 | |||||||||
G
|
A
|
A
|
C
|
R
|
H
|
M
|
D
|
I
|
F
|
200 |
L
|
G
|
I
|
L
|
L
|
F
|
L
|
L
|
C
|
C
|
210 |
P
|
L
|
M
|
V
|
L
|
P
|
C
|
L
|
A
|
L
|
220 |
I
|
L
|
H
|
V
|
E
|
C
|
R
|
A
|
R
|
R
|
230 |
ICL3 | TM6 | ||||||||
R
|
Q
|
R
|
S
|
A
|
K
|
L
|
N
|
H
|
V
|
240 |
I
|
L
|
A
|
M
|
V
|
S
|
V
|
F
|
L
|
V
|
250 |
S
|
S
|
I
|
Y
|
L
|
G
|
I
|
D
|
W
|
F
|
260 |
ECL3 | |||||||||
L
|
F
|
W
|
V
|
F
|
Q
|
I
|
P
|
A
|
P
|
270 |
TM7 | |||||||||
F
|
P
|
E
|
Y
|
V
|
T
|
D
|
L
|
C
|
I
|
280 |
C
|
I
|
N
|
S
|
S
|
A
|
K
|
P
|
I
|
V
|
290 |
H8 | |||||||||
Y
|
F
|
L
|
A
|
G
|
R
|
D
|
K
|
S
|
Q
|
300 |
R
|
L
|
W
|
E
|
P
|
L
|
R
|
V
|
V
|
F
|
310 |
C-term | |||||||||
Q
|
R
|
A
|
L
|
R
|
D
|
G
|
A
|
E
|
L
|
320 |
G
|
E
|
A
|
G
|
G
|
S
|
T
|
P
|
N
|
T
|
330 |
V
|
T
|
M
|
E
|
M
|
Q
|
C
|
P
|
P
|
G
|
340 |
N
|
A
|
S
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available