MRGPRX3 (mrgx3_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX3

GENE

MRGPRX3 (MRGX3, SNSR1, SNSR2)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Mas-related G-protein coupled receptor member X3, Sensory neuron-specific G-protein coupled receptor 1/2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
S
T
I
P
V
L
G
T
10
                   
E
L
T
P
I
N
G
R
E
E
20
          TM1    
T
P
C
Y
K
Q
T
L
S
F
30
                   
T
G
L
T
C
I
V
S
L
V
40
                   
A
L
T
G
N
A
V
V
L
W
50
            ICL1
L
L
G
C
R
M
R
R
N
A
60
TM2              
V
S
I
Y
I
L
N
L
V
A
70
                   
A
D
F
L
F
L
S
G
H
I
80
                   
I
C
S
P
L
R
L
I
N
I
90
ECL1 TM3      
R
H
P
I
S
K
I
L
S
P
100
                   
V
M
T
F
P
Y
F
I
G
L
110
                   
S
M
L
S
A
I
S
T
E
R
120
            ICL2
C
L
S
I
L
W
P
I
W
Y
130
        TM4      
H
C
R
R
P
R
Y
L
S
S
140
                   
V
M
C
V
L
L
W
A
L
S
150
                   
L
L
R
S
I
L
E
W
M
F
160
  ECL2          
C
D
F
L
F
S
G
A
N
S
170
TM5              
V
W
C
E
T
S
D
F
I
T
180
                   
I
A
W
L
V
F
L
C
V
V
190
                   
L
C
G
S
S
L
V
L
L
V
200
          ICL3  
R
I
L
C
G
S
R
K
M
P
210
TM6              
L
T
R
L
Y
V
T
I
L
L
220
                   
T
V
L
V
F
L
L
C
G
L
230
                   
P
F
G
I
Q
W
A
L
F
S
240
      ECL3      
R
I
H
L
D
W
K
V
L
F
250
TM7              
C
H
V
H
L
V
S
I
F
L
260
                   
S
A
L
N
S
S
A
N
P
I
270
                   
I
Y
F
F
V
G
S
F
R
Q
280
C-term        
R
Q
N
R
Q
N
L
K
L
V
290
                   
L
Q
R
A
L
Q
D
T
P
E
300
                   
V
D
E
G
G
G
W
L
P
Q
310
                   
E
T
L
E
L
S
G
S
R
L
320
   
E
Q

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R R ICL1ECL1 N I R H P ECL1ICL2 P I W Y H C R R ICL2ECL2 D F L F S G A ECL2ICL3 S R K M ICL3ECL3 L D W K V ECL3N-term M D S T I P V L G T E L T P I N G R E E T P C Y K N-termC-term Q R Q N R Q N L K L V L Q R A L Q D T P E V D E G G G W L P Q E T L E L S G S R L E Q C-term Q T L S F T G L T C I V S L V A L T G N A V V L W L L G C R M N A V S I Y I L N L V A A D F L F L S G H I I C S P L R L I I S K I L S P V M T F P Y F I G L S M L S A I S T E R C L S I L W P R Y L S S V M C V L L W A L S L L R S I L E W M F C N S V W C E T S D F I T I A W L V F L C V V L C G S S L V L L V R I L C G P L T R L Y V T I L L T V L V F L L C G L P F G I Q W A L F S R I H L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G T L A V L S V I C T L G T F S L T 1 L N L V A A D F L F L S G H I I C S P L 2 A S L M S L G I F Y P F T M V P S L I K 3 S S V M C V L L W A L S L L R S I L E W 4 S S G C L V V C L F V L W A I T I F D S 5 L L T V L V F L L C G L P F G I Q W A L 6 I P N A S S N L A S L F I S V L H V H 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

mrgx3_human active,

mrgx3_human inactive

STRUCTURES

No structures available