NMU2 receptor (nmur2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuromedin U receptors NMU2 receptor
GENE
NMUR2 (NMU2R, TGR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuromedin-U receptor 2, NMU-R2, G-protein coupled receptor FM-4, G-protein coupled receptor TGR-1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
G
|
M
|
E
|
K
|
L
|
Q
|
N
|
A
|
10 |
S
|
W
|
I
|
Y
|
Q
|
Q
|
K
|
L
|
E
|
D
|
20 |
P
|
F
|
Q
|
K
|
H
|
L
|
N
|
S
|
T
|
E
|
30 |
E
|
Y
|
L
|
A
|
F
|
L
|
C
|
G
|
P
|
R
|
40 |
TM1 | |||||||||
R
|
S
|
H
|
F
|
F
|
L
|
P
|
V
|
S
|
V
|
50 |
V
|
Y
|
V
|
P
|
I
|
F
|
V
|
V
|
G
|
V
|
60 |
I
|
G
|
N
|
V
|
L
|
V
|
C
|
L
|
V
|
I
|
70 |
ICL1 | TM2 | ||||||||
L
|
Q
|
H
|
Q
|
A
|
M
|
K
|
T
|
P
|
T
|
80 |
N
|
Y
|
Y
|
L
|
F
|
S
|
L
|
A
|
V
|
S
|
90 |
D
|
L
|
L
|
V
|
L
|
L
|
L
|
G
|
M
|
P
|
100 |
L
|
E
|
V
|
Y
|
E
|
M
|
W
|
R
|
N
|
Y
|
110 |
ECL1 | TM3 | ||||||||
P
|
F
|
L
|
F
|
G
|
P
|
V
|
G
|
C
|
Y
|
120 |
F
|
K
|
T
|
A
|
L
|
F
|
E
|
T
|
V
|
C
|
130 |
F
|
A
|
S
|
I
|
L
|
S
|
I
|
T
|
T
|
V
|
140 |
S
|
V
|
E
|
R
|
Y
|
V
|
A
|
I
|
L
|
H
|
150 |
ICL2 | |||||||||
P
|
F
|
R
|
A
|
K
|
L
|
Q
|
S
|
T
|
R
|
160 |
TM4 | |||||||||
R
|
R
|
A
|
L
|
R
|
I
|
L
|
G
|
I
|
V
|
170 |
W
|
G
|
F
|
S
|
V
|
L
|
F
|
S
|
L
|
P
|
180 |
ECL2 | |||||||||
N
|
T
|
S
|
I
|
H
|
G
|
I
|
K
|
F
|
H
|
190 |
Y
|
F
|
P
|
N
|
G
|
S
|
L
|
V
|
P
|
G
|
200 |
S
|
A
|
T
|
C
|
T
|
V
|
I
|
K
|
P
|
M
|
210 |
TM5 | |||||||||
W
|
I
|
Y
|
N
|
F
|
I
|
I
|
Q
|
V
|
T
|
220 |
S
|
F
|
L
|
F
|
Y
|
L
|
L
|
P
|
M
|
T
|
230 |
V
|
I
|
S
|
V
|
L
|
Y
|
Y
|
L
|
M
|
A
|
240 |
L
|
R
|
L
|
K
|
K
|
D
|
K
|
S
|
L
|
E
|
250 |
ICL3 | TM6 | ||||||||
A
|
D
|
E
|
G
|
N
|
A
|
N
|
I
|
Q
|
R
|
260 |
P
|
C
|
R
|
K
|
S
|
V
|
N
|
K
|
M
|
L
|
270 |
F
|
V
|
L
|
V
|
L
|
V
|
F
|
A
|
I
|
C
|
280 |
W
|
A
|
P
|
F
|
H
|
I
|
D
|
R
|
L
|
F
|
290 |
ECL3 | |||||||||
F
|
S
|
F
|
V
|
E
|
E
|
W
|
S
|
E
|
S
|
300 |
TM7 | |||||||||
L
|
A
|
A
|
V
|
F
|
N
|
L
|
V
|
H
|
V
|
310 |
V
|
S
|
G
|
V
|
F
|
F
|
Y
|
L
|
S
|
S
|
320 |
A
|
V
|
N
|
P
|
I
|
I
|
Y
|
N
|
L
|
L
|
330 |
H8 | |||||||||
S
|
R
|
R
|
F
|
Q
|
A
|
A
|
F
|
Q
|
N
|
340 |
V
|
I
|
S
|
S
|
F
|
H
|
K
|
Q
|
W
|
H
|
350 |
C-term | |||||||||
S
|
Q
|
H
|
D
|
P
|
Q
|
L
|
P
|
P
|
A
|
360 |
Q
|
R
|
N
|
I
|
F
|
L
|
T
|
E
|
C
|
H
|
370 |
F
|
V
|
E
|
L
|
T
|
E
|
D
|
I
|
G
|
P
|
380 |
Q
|
F
|
P
|
C
|
Q
|
S
|
S
|
M
|
H
|
N
|
390 |
S
|
H
|
L
|
P
|
A
|
A
|
L
|
S
|
S
|
E
|
400 |
Q
|
M
|
S
|
R
|
T
|
N
|
Y
|
Q
|
S
|
F
|
410 |
H
|
F
|
N
|
K
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
neuromedin S-33, neuromedin S-36, neuromedin U-23, neuromedin U-25
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page