NPFF2 receptor (npff2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide FF/neuropeptide AF receptors NPFF2 receptor
GENE
NPFFR2 (GPR74, NPFF2, NPGPR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptide FF receptor 2, G-protein coupled receptor 74, G-protein coupled receptor HLWAR77, Neuropeptide G-protein coupled receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
F
|
F
|
G
|
T
|
P
|
A
|
A
|
10 |
S
|
W
|
C
|
L
|
L
|
E
|
S
|
D
|
V
|
S
|
20 |
S
|
A
|
P
|
D
|
K
|
E
|
A
|
G
|
R
|
E
|
30 |
R
|
R
|
A
|
L
|
S
|
V
|
Q
|
Q
|
R
|
G
|
40 |
G
|
P
|
A
|
W
|
S
|
G
|
S
|
L
|
E
|
W
|
50 |
S
|
R
|
Q
|
S
|
A
|
G
|
D
|
R
|
R
|
R
|
60 |
L
|
G
|
L
|
S
|
R
|
Q
|
T
|
A
|
K
|
S
|
70 |
S
|
W
|
S
|
R
|
S
|
R
|
D
|
R
|
T
|
C
|
80 |
C
|
C
|
R
|
R
|
A
|
W
|
W
|
I
|
L
|
V
|
90 |
P
|
A
|
A
|
D
|
R
|
A
|
R
|
R
|
E
|
R
|
100 |
F
|
I
|
M
|
N
|
E
|
K
|
W
|
D
|
T
|
N
|
110 |
S
|
S
|
E
|
N
|
W
|
H
|
P
|
I
|
W
|
N
|
120 |
V
|
N
|
D
|
T
|
K
|
H
|
H
|
L
|
Y
|
S
|
130 |
D
|
I
|
N
|
I
|
T
|
Y
|
V
|
N
|
Y
|
Y
|
140 |
TM1 | |||||||||
L
|
H
|
Q
|
P
|
Q
|
V
|
A
|
A
|
I
|
F
|
150 |
I
|
I
|
S
|
Y
|
F
|
L
|
I
|
F
|
F
|
L
|
160 |
C
|
M
|
M
|
G
|
N
|
T
|
V
|
V
|
C
|
F
|
170 |
ICL1 | |||||||||
I
|
V
|
M
|
R
|
N
|
K
|
H
|
M
|
H
|
T
|
180 |
TM2 | |||||||||
V
|
T
|
N
|
L
|
F
|
I
|
L
|
N
|
L
|
A
|
190 |
I
|
S
|
D
|
L
|
L
|
V
|
G
|
I
|
F
|
C
|
200 |
M
|
P
|
I
|
T
|
L
|
L
|
D
|
N
|
I
|
I
|
210 |
ECL1 | TM3 | ||||||||
A
|
G
|
W
|
P
|
F
|
G
|
N
|
T
|
M
|
C
|
220 |
K
|
I
|
S
|
G
|
L
|
V
|
Q
|
G
|
I
|
S
|
230 |
V
|
A
|
A
|
S
|
V
|
F
|
T
|
L
|
V
|
A
|
240 |
I
|
A
|
V
|
D
|
R
|
F
|
Q
|
C
|
V
|
V
|
250 |
ICL2 | TM4 | ||||||||
Y
|
P
|
F
|
K
|
P
|
K
|
L
|
T
|
I
|
K
|
260 |
T
|
A
|
F
|
V
|
I
|
I
|
M
|
I
|
I
|
W
|
270 |
V
|
L
|
A
|
I
|
T
|
I
|
M
|
S
|
P
|
S
|
280 |
ECL2 | |||||||||
A
|
V
|
M
|
L
|
H
|
V
|
Q
|
E
|
E
|
K
|
290 |
Y
|
Y
|
R
|
V
|
R
|
L
|
N
|
S
|
Q
|
N
|
300 |
K
|
T
|
S
|
P
|
V
|
Y
|
W
|
C
|
R
|
E
|
310 |
TM5 | |||||||||
D
|
W
|
P
|
N
|
Q
|
E
|
M
|
R
|
K
|
I
|
320 |
Y
|
T
|
T
|
V
|
L
|
F
|
A
|
N
|
I
|
Y
|
330 |
L
|
A
|
P
|
L
|
S
|
L
|
I
|
V
|
I
|
M
|
340 |
Y
|
G
|
R
|
I
|
G
|
I
|
S
|
L
|
F
|
R
|
350 |
ICL3 | |||||||||
A
|
A
|
V
|
P
|
H
|
T
|
G
|
R
|
K
|
N
|
360 |
TM6 | |||||||||
Q
|
E
|
Q
|
W
|
H
|
V
|
V
|
S
|
R
|
K
|
370 |
K
|
Q
|
K
|
I
|
I
|
K
|
M
|
L
|
L
|
I
|
380 |
V
|
A
|
L
|
L
|
F
|
I
|
L
|
S
|
W
|
L
|
390 |
P
|
L
|
W
|
T
|
L
|
M
|
M
|
L
|
S
|
D
|
400 |
ECL3 | |||||||||
Y
|
A
|
D
|
L
|
S
|
P
|
N
|
E
|
L
|
Q
|
410 |
TM7 | |||||||||
I
|
I
|
N
|
I
|
Y
|
I
|
Y
|
P
|
F
|
A
|
420 |
H
|
W
|
L
|
A
|
F
|
G
|
N
|
S
|
S
|
V
|
430 |
H8 | |||||||||
N
|
P
|
I
|
I
|
Y
|
G
|
F
|
F
|
N
|
E
|
440 |
N
|
F
|
R
|
R
|
G
|
F
|
Q
|
E
|
A
|
F
|
450 |
Q
|
L
|
Q
|
L
|
C
|
Q
|
K
|
R
|
A
|
K
|
460 |
C-term | |||||||||
P
|
M
|
E
|
A
|
Y
|
A
|
L
|
K
|
A
|
K
|
470 |
S
|
H
|
V
|
L
|
I
|
N
|
T
|
S
|
N
|
Q
|
480 |
L
|
V
|
Q
|
E
|
S
|
T
|
F
|
Q
|
N
|
P
|
490 |
H
|
G
|
E
|
T
|
L
|
L
|
Y
|
R
|
K
|
S
|
500 |
A
|
E
|
K
|
P
|
Q
|
Q
|
E
|
L
|
V
|
M
|
510 |
E
|
E
|
L
|
K
|
E
|
T
|
T
|
N
|
S
|
S
|
520 |
E
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
QRFP43 (43RFa), neuropeptide FF, neuropeptide AF, RFRP-3, PrRP-31, neuropeptide SF, RFRP-1
STRUCTURE MODELS
STRUCTURES
No structures available