OR2A1 (or2a1_human)

FAMILY

Class O2 (tetrapod specific odorant) Odorant receptors Odorant family 2 OR2A1

GENE

OR2A1 (OR2A42)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Olfactory receptor 2A1/2A42, Olfactory receptor OR7-16, Olfactory receptor OR7-19

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
E
N
Q
T
M
V
T
E
10
                   
F
L
L
L
G
F
L
L
G
P
20
TM1              
R
I
Q
M
L
L
F
G
L
F
30
                   
S
L
F
Y
I
F
T
L
L
G
40
                   
N
G
A
I
L
G
L
I
S
L
50
  ICL1 TM2    
D
S
R
L
H
T
P
M
Y
F
60
                   
F
L
S
H
L
A
V
V
D
I
70
                   
A
Y
T
R
N
T
V
P
Q
M
80
            ECL1
L
A
N
L
L
H
P
A
K
P
90
  TM3            
I
S
F
A
G
C
M
T
Q
T
100
                   
F
L
C
L
S
F
G
H
S
E
110
                   
C
L
L
L
V
L
M
S
Y
D
120
                   
R
Y
V
A
I
C
H
P
L
R
130
ICL2   TM4    
Y
S
V
I
M
T
W
R
V
C
140
                   
I
T
L
A
V
T
S
W
T
C
150
                   
G
S
L
L
A
L
A
H
V
V
160
      ECL2      
L
I
L
R
L
P
F
S
G
P
170
                   
H
E
I
N
H
F
F
C
E
I
180
                   
L
S
V
L
R
L
A
C
A
D
190
TM5              
T
W
L
N
Q
V
V
I
F
A
200
                   
A
C
V
F
F
L
V
G
P
P
210
                   
S
L
V
L
V
S
Y
S
H
I
220
            ICL3
L
A
A
I
L
R
I
Q
S
G
230
TM6              
E
G
R
R
K
A
F
S
T
C
240
                   
S
S
H
L
C
V
V
G
L
F
250
                   
F
G
S
A
I
I
M
Y
M
A
260
ECL3 TM7      
P
K
S
R
H
P
E
E
Q
Q
270
                   
K
V
F
F
L
F
Y
S
F
F
280
                   
N
P
T
L
N
P
L
I
Y
S
290
    H8            
L
R
N
G
E
V
K
G
A
L
300
        C-term
R
R
A
L
G
K
E
S
H
S
310

LINKS

UniProt

DIAGRAMS

7TM

ICL1 S R L H ICL1ECL1 P A K P I ECL1ICL2 P L R Y S V I M ICL2ECL2 R L P F S G P H E I N H F F C E I L S V L R L A C A D ECL2ICL3 I Q ICL3ECL3 P K S R ECL3N-term M G E N Q T M V T E F L L L G F L L N-termC-term G K E S H S C-term G P R I Q M L L F G L F S L F Y I F T L L G N G A I L G L I S L D T P M Y F F L S H L A V V D I A Y T R N T V P Q M L A N L L H S F A G C M T Q T F L C L S F G H S E C L L L V L M S Y D R Y V A I C H T W R V C I T L A V T S W T C G S L L A L A H V V L I L T W L N Q V V I F A A C V F F L V G P P S L V L V S Y S H I L A A I L R S G E G R R K A F S T C S S H L C V V G L F F G S A I I M Y M A H P E E Q Q K V F F L F Y S F F N P T L N P L I Y S L R N G E L R R V K G A A L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L L T F I Y F L S F L G F L L M Q 1 S H L A V V D I A Y T R N T V P Q M L A 2 L V L L L C E S H G F S L C L F T Q T M 3 C I T L A V T S W T C G S L L A L A H V 4 Y S V L V L S P P G V L F F V C A A F I 5 S S H L C V V G L F F G S A I I M Y M A 6 L P N L T P N F F S Y F L F F V K Q Q 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

or2a1_human active,

or2a1_human inactive

STRUCTURES

No structures available