RXFP2 (rxfp2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Relaxin family peptide receptors RXFP2
GENE
RXFP2 (GPR106, GREAT, LGR8)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
I
|
V
|
F
|
L
|
V
|
F
|
K
|
H
|
L
|
10 |
F
|
S
|
L
|
R
|
L
|
I
|
T
|
M
|
F
|
F
|
20 |
L
|
L
|
H
|
F
|
I
|
V
|
L
|
I
|
N
|
V
|
30 |
K
|
D
|
F
|
A
|
L
|
T
|
Q
|
G
|
S
|
M
|
40 |
I
|
T
|
P
|
S
|
C
|
Q
|
K
|
G
|
Y
|
F
|
50 |
P
|
C
|
G
|
N
|
L
|
T
|
K
|
C
|
L
|
P
|
60 |
R
|
A
|
F
|
H
|
C
|
D
|
G
|
K
|
D
|
D
|
70 |
C
|
G
|
N
|
G
|
A
|
D
|
E
|
E
|
N
|
C
|
80 |
G
|
D
|
T
|
S
|
G
|
W
|
A
|
T
|
I
|
F
|
90 |
G
|
T
|
V
|
H
|
G
|
N
|
A
|
N
|
S
|
V
|
100 |
A
|
L
|
T
|
Q
|
E
|
C
|
F
|
L
|
K
|
Q
|
110 |
Y
|
P
|
Q
|
C
|
C
|
D
|
C
|
K
|
E
|
T
|
120 |
E
|
L
|
E
|
C
|
V
|
N
|
G
|
D
|
L
|
K
|
130 |
S
|
V
|
P
|
M
|
I
|
S
|
N
|
N
|
V
|
T
|
140 |
L
|
L
|
S
|
L
|
K
|
K
|
N
|
K
|
I
|
H
|
150 |
S
|
L
|
P
|
D
|
K
|
V
|
F
|
I
|
K
|
Y
|
160 |
T
|
K
|
L
|
K
|
K
|
I
|
F
|
L
|
Q
|
H
|
170 |
N
|
C
|
I
|
R
|
H
|
I
|
S
|
R
|
K
|
A
|
180 |
F
|
F
|
G
|
L
|
C
|
N
|
L
|
Q
|
I
|
L
|
190 |
Y
|
L
|
N
|
H
|
N
|
C
|
I
|
T
|
T
|
L
|
200 |
R
|
P
|
G
|
I
|
F
|
K
|
D
|
L
|
H
|
Q
|
210 |
L
|
T
|
W
|
L
|
I
|
L
|
D
|
D
|
N
|
P
|
220 |
I
|
T
|
R
|
I
|
S
|
Q
|
R
|
L
|
F
|
T
|
230 |
G
|
L
|
N
|
S
|
L
|
F
|
F
|
L
|
S
|
M
|
240 |
V
|
N
|
N
|
Y
|
L
|
E
|
A
|
L
|
P
|
K
|
250 |
Q
|
M
|
C
|
A
|
Q
|
M
|
P
|
Q
|
L
|
N
|
260 |
W
|
V
|
D
|
L
|
E
|
G
|
N
|
R
|
I
|
K
|
270 |
Y
|
L
|
T
|
N
|
S
|
T
|
F
|
L
|
S
|
C
|
280 |
D
|
S
|
L
|
T
|
V
|
L
|
F
|
L
|
P
|
R
|
290 |
N
|
Q
|
I
|
G
|
F
|
V
|
P
|
E
|
K
|
T
|
300 |
F
|
S
|
S
|
L
|
K
|
N
|
L
|
G
|
E
|
L
|
310 |
D
|
L
|
S
|
S
|
N
|
T
|
I
|
T
|
E
|
L
|
320 |
S
|
P
|
H
|
L
|
F
|
K
|
D
|
L
|
K
|
L
|
330 |
L
|
Q
|
K
|
L
|
N
|
L
|
S
|
S
|
N
|
P
|
340 |
L
|
M
|
Y
|
L
|
H
|
K
|
N
|
Q
|
F
|
E
|
350 |
S
|
L
|
K
|
Q
|
L
|
Q
|
S
|
L
|
D
|
L
|
360 |
E
|
R
|
I
|
E
|
I
|
P
|
N
|
I
|
N
|
T
|
370 |
R
|
M
|
F
|
Q
|
P
|
M
|
K
|
N
|
L
|
S
|
380 |
H
|
I
|
Y
|
F
|
K
|
N
|
F
|
R
|
Y
|
C
|
390 |
S
|
Y
|
A
|
P
|
H
|
V
|
R
|
I
|
C
|
M
|
400 |
P
|
L
|
T
|
D
|
G
|
I
|
S
|
S
|
F
|
E
|
410 |
TM1 | |||||||||
D
|
L
|
L
|
A
|
N
|
N
|
I
|
L
|
R
|
I
|
420 |
F
|
V
|
W
|
V
|
I
|
A
|
F
|
I
|
T
|
C
|
430 |
F
|
G
|
N
|
L
|
F
|
V
|
I
|
G
|
M
|
R
|
440 |
ICL1 | TM2 | ||||||||
S
|
F
|
I
|
K
|
A
|
E
|
N
|
T
|
T
|
H
|
450 |
A
|
M
|
S
|
I
|
K
|
I
|
L
|
C
|
C
|
A
|
460 |
D
|
C
|
L
|
M
|
G
|
V
|
Y
|
L
|
F
|
F
|
470 |
V
|
G
|
I
|
F
|
D
|
I
|
K
|
Y
|
R
|
G
|
480 |
ECL1 | TM3 | ||||||||
Q
|
Y
|
Q
|
K
|
Y
|
A
|
L
|
L
|
W
|
M
|
490 |
E
|
S
|
V
|
Q
|
C
|
R
|
L
|
M
|
G
|
F
|
500 |
L
|
A
|
M
|
L
|
S
|
T
|
E
|
V
|
S
|
V
|
510 |
L
|
L
|
L
|
T
|
Y
|
L
|
T
|
L
|
E
|
K
|
520 |
ICL2 | |||||||||
F
|
L
|
V
|
I
|
V
|
F
|
P
|
F
|
S
|
N
|
530 |
TM4 | |||||||||
I
|
R
|
P
|
G
|
K
|
R
|
Q
|
T
|
S
|
V
|
540 |
I
|
L
|
I
|
C
|
I
|
W
|
M
|
A
|
G
|
F
|
550 |
L
|
I
|
A
|
V
|
I
|
P
|
F
|
W
|
N
|
K
|
560 |
ECL2 | |||||||||
D
|
Y
|
F
|
G
|
N
|
F
|
Y
|
G
|
K
|
N
|
570 |
G
|
V
|
C
|
F
|
P
|
L
|
Y
|
Y
|
D
|
Q
|
580 |
TM5 | |||||||||
T
|
E
|
D
|
I
|
G
|
S
|
K
|
G
|
Y
|
S
|
590 |
L
|
G
|
I
|
F
|
L
|
G
|
V
|
N
|
L
|
L
|
600 |
A
|
F
|
L
|
I
|
I
|
V
|
F
|
S
|
Y
|
I
|
610 |
T
|
M
|
F
|
C
|
S
|
I
|
Q
|
K
|
T
|
A
|
620 |
ICL3 | TM6 | ||||||||
L
|
Q
|
T
|
T
|
E
|
V
|
R
|
N
|
C
|
F
|
630 |
G
|
R
|
E
|
V
|
A
|
V
|
A
|
N
|
R
|
F
|
640 |
F
|
F
|
I
|
V
|
F
|
S
|
D
|
A
|
I
|
C
|
650 |
W
|
I
|
P
|
V
|
F
|
V
|
V
|
K
|
I
|
L
|
660 |
ECL3 | |||||||||
S
|
L
|
F
|
R
|
V
|
E
|
I
|
P
|
D
|
T
|
670 |
TM7 | |||||||||
M
|
T
|
S
|
W
|
I
|
V
|
I
|
F
|
F
|
L
|
680 |
P
|
V
|
N
|
S
|
A
|
L
|
N
|
P
|
I
|
L
|
690 |
H8 | |||||||||
Y
|
T
|
L
|
T
|
T
|
N
|
F
|
F
|
K
|
D
|
700 |
K
|
L
|
K
|
Q
|
L
|
L
|
H
|
K
|
H
|
Q
|
710 |
C-term | |||||||||
R
|
K
|
S
|
I
|
F
|
K
|
I
|
K
|
K
|
K
|
720 |
S
|
L
|
S
|
T
|
S
|
I
|
V
|
W
|
I
|
E
|
730 |
D
|
S
|
S
|
S
|
L
|
K
|
L
|
G
|
V
|
L
|
740 |
N
|
K
|
I
|
T
|
L
|
G
|
D
|
S
|
I
|
M
|
750 |
K
|
P
|
V
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
INSL3, relaxin, relaxin-1, relaxin-3
STRUCTURE MODELS
STRUCTURES
No structures available