TAS2R38 (t2r38_human)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R38

GENE

TAS2R38 (PTC)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
L
T
L
T
R
I
R
T
V
10
TM1              
S
Y
E
V
R
S
T
F
L
F
20
                   
I
S
V
L
E
F
A
V
G
F
30
                   
L
T
N
A
F
V
F
L
V
N
40
                   
F
W
D
V
V
K
R
Q
A
L
50
TM2              
S
N
S
D
C
V
L
L
C
L
60
                   
S
I
S
R
L
F
L
H
G
L
70
                   
L
F
L
S
A
I
Q
L
T
H
80
  ECL1 TM3    
F
Q
K
L
S
E
P
L
N
H
90
                   
S
Y
Q
A
I
I
M
L
W
M
100
                   
I
A
N
Q
A
N
L
W
L
A
110
                   
A
C
L
S
L
L
Y
C
S
K
120
    ICL2        
L
I
R
F
S
H
T
F
L
I
130
        TM4      
C
L
A
S
W
V
S
R
K
I
140
                   
S
Q
M
L
L
G
I
I
L
C
150
                   
S
C
I
C
T
V
L
C
V
W
160
      ECL2      
C
F
F
S
R
P
H
F
T
V
170
                   
T
T
V
L
F
M
N
N
N
T
180
                   
R
L
N
W
Q
I
K
D
L
N
190
      TM5        
L
F
Y
S
F
L
F
C
Y
L
200
                   
W
S
V
P
P
F
L
L
F
L
210
                   
V
S
S
G
M
L
T
V
S
L
220
                   
G
R
H
M
R
T
M
K
V
Y
230
  ICL3 TM6    
T
R
N
S
R
D
P
S
L
E
240
                   
A
H
I
K
A
L
K
S
L
V
250
                   
S
F
F
C
F
F
V
I
S
S
260
                   
C
A
A
F
I
S
V
P
L
L
270
    ECL3 TM7  
I
L
W
R
D
K
I
G
V
M
280
                   
V
C
V
G
I
M
A
A
C
P
290
                   
S
G
H
A
A
I
L
I
S
G
300
H8                
N
A
K
L
R
R
A
V
M
T
310
                   
I
L
L
W
A
Q
S
S
L
K
320
C-term        
V
R
A
D
H
K
A
D
S
R
330
     
T
L
C

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 A L ICL1ECL1 Q K L ECL1ICL2 R F S H T F L I C L A S ICL2ECL2 S R P H F T V T T V L F M N N N T R L N W Q I K D L N L F Y ECL2ICL3 R N S R ICL3ECL3 W R D ECL3N-term M L T L T R I R T V N-termC-term K V R A D H K A D S R T L C C-term S Y E V R S T F L F I S V L E F A V G F L T N A F V F L V N F W D V V K R Q S N S D C V L L C L S I S R L F L H G L L F L S A I Q L T H F S E P L N H S Y Q A I I M L W M I A N Q A N L W L A A C L S L L Y C S K L I W V S R K I S Q M L L G I I L C S C I C T V L C V W C F F S F L F C Y L W S V P P F L L F L V S S G M L T V S L G R H M R T M K V Y T D P S L E A H I K A L K S L V S F F C F F V I S S C A A F I S V P L L I L K I G V M V C V G I M A A C P S G H A A I L I S G N A K V M T A Q S L R R A I L L W S L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N T L F G V A F E L V S I F L F T S R 1 L C L S I S R L F L H G L L F L S A I Q 2 C A A L W L N A Q N A I M W L M I I A Q 3 I S Q M L L G I I L C S C I C T V L C V 4 S S V L F L L F P P V S W L Y C F L F S 5 L V S F F C F F V I S S C A A F I S V P 6 A A H G S P C A A M I G V C V M V G I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

t2r38_human inactive,

t2r38_human active

STRUCTURES

No structures available