TAS2R38 (t2r38_human)
FAMILY
Class T2 (Taste 2) Sensory receptors Taste 2 receptors TAS2R38
GENE
TAS2R38 (PTC)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
T
|
L
|
T
|
R
|
I
|
R
|
T
|
V
|
10 |
TM1 | |||||||||
S
|
Y
|
E
|
V
|
R
|
S
|
T
|
F
|
L
|
F
|
20 |
I
|
S
|
V
|
L
|
E
|
F
|
A
|
V
|
G
|
F
|
30 |
L
|
T
|
N
|
A
|
F
|
V
|
F
|
L
|
V
|
N
|
40 |
F
|
W
|
D
|
V
|
V
|
K
|
R
|
Q
|
A
|
L
|
50 |
TM2 | |||||||||
S
|
N
|
S
|
D
|
C
|
V
|
L
|
L
|
C
|
L
|
60 |
S
|
I
|
S
|
R
|
L
|
F
|
L
|
H
|
G
|
L
|
70 |
L
|
F
|
L
|
S
|
A
|
I
|
Q
|
L
|
T
|
H
|
80 |
ECL1 | TM3 | ||||||||
F
|
Q
|
K
|
L
|
S
|
E
|
P
|
L
|
N
|
H
|
90 |
S
|
Y
|
Q
|
A
|
I
|
I
|
M
|
L
|
W
|
M
|
100 |
I
|
A
|
N
|
Q
|
A
|
N
|
L
|
W
|
L
|
A
|
110 |
A
|
C
|
L
|
S
|
L
|
L
|
Y
|
C
|
S
|
K
|
120 |
ICL2 | |||||||||
L
|
I
|
R
|
F
|
S
|
H
|
T
|
F
|
L
|
I
|
130 |
TM4 | |||||||||
C
|
L
|
A
|
S
|
W
|
V
|
S
|
R
|
K
|
I
|
140 |
S
|
Q
|
M
|
L
|
L
|
G
|
I
|
I
|
L
|
C
|
150 |
S
|
C
|
I
|
C
|
T
|
V
|
L
|
C
|
V
|
W
|
160 |
ECL2 | |||||||||
C
|
F
|
F
|
S
|
R
|
P
|
H
|
F
|
T
|
V
|
170 |
T
|
T
|
V
|
L
|
F
|
M
|
N
|
N
|
N
|
T
|
180 |
R
|
L
|
N
|
W
|
Q
|
I
|
K
|
D
|
L
|
N
|
190 |
TM5 | |||||||||
L
|
F
|
Y
|
S
|
F
|
L
|
F
|
C
|
Y
|
L
|
200 |
W
|
S
|
V
|
P
|
P
|
F
|
L
|
L
|
F
|
L
|
210 |
V
|
S
|
S
|
G
|
M
|
L
|
T
|
V
|
S
|
L
|
220 |
G
|
R
|
H
|
M
|
R
|
T
|
M
|
K
|
V
|
Y
|
230 |
ICL3 | TM6 | ||||||||
T
|
R
|
N
|
S
|
R
|
D
|
P
|
S
|
L
|
E
|
240 |
A
|
H
|
I
|
K
|
A
|
L
|
K
|
S
|
L
|
V
|
250 |
S
|
F
|
F
|
C
|
F
|
F
|
V
|
I
|
S
|
S
|
260 |
C
|
A
|
A
|
F
|
I
|
S
|
V
|
P
|
L
|
L
|
270 |
ECL3 | TM7 | ||||||||
I
|
L
|
W
|
R
|
D
|
K
|
I
|
G
|
V
|
M
|
280 |
V
|
C
|
V
|
G
|
I
|
M
|
A
|
A
|
C
|
P
|
290 |
S
|
G
|
H
|
A
|
A
|
I
|
L
|
I
|
S
|
G
|
300 |
H8 | |||||||||
N
|
A
|
K
|
L
|
R
|
R
|
A
|
V
|
M
|
T
|
310 |
I
|
L
|
L
|
W
|
A
|
Q
|
S
|
S
|
L
|
K
|
320 |
C-term | |||||||||
V
|
R
|
A
|
D
|
H
|
K
|
A
|
D
|
S
|
R
|
330 |
T
|
L
|
C
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available