TAS2R60 (t2r60_human)

FAMILY

Class T2 (Taste 2) Sensory receptors Taste 2 receptors TAS2R60

GENE

TAS2R60

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 60, T2R60, Taste receptor type 2 member 56, T2R56

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
G
D
H
M
V
L
G
S
10
    TM1          
S
V
T
D
K
K
A
I
I
L
20
                   
V
T
I
L
L
L
L
R
L
V
30
                   
A
I
A
G
N
G
F
I
T
A
40
                   
A
L
G
V
E
W
V
L
R
R
50
ICL1 TM2      
M
L
L
P
C
D
K
L
L
V
60
                   
S
L
G
A
S
R
F
C
L
Q
70
                   
S
V
V
M
G
K
T
I
Y
V
80
      ECL1 TM3
F
L
H
P
M
A
F
P
Y
N
90
                   
P
V
L
Q
F
L
A
F
Q
W
100
                   
D
F
L
N
A
A
T
L
W
S
110
                   
S
T
W
L
S
V
F
Y
C
V
120
      ICL2      
K
I
A
T
F
T
H
P
V
F
130
          TM4    
F
W
L
K
H
K
L
S
G
W
140
                   
L
P
W
M
L
F
S
S
V
G
150
                   
L
S
S
F
T
T
I
L
F
F
160
        ECL2    
I
G
N
H
R
M
Y
Q
N
Y
170
                   
L
R
N
H
L
Q
P
W
N
V
180
                   
T
G
D
S
I
R
S
Y
C
E
190
      TM5        
K
F
Y
L
F
P
L
K
M
I
200
                   
T
W
T
M
P
T
A
V
F
F
210
                   
I
C
M
I
L
L
I
T
S
L
220
                   
G
R
H
R
K
K
A
L
L
T
230
  ICL3 TM6    
T
S
G
F
R
E
P
S
V
Q
240
                   
A
H
I
K
A
L
L
A
L
L
250
                   
S
F
A
M
L
F
I
S
Y
F
260
                   
L
S
L
V
F
S
A
A
G
I
270
    ECL3 TM7  
F
P
P
L
D
F
K
F
W
V
280
                   
W
E
S
V
I
Y
L
C
A
A
290
                   
V
H
P
I
I
L
L
F
S
N
300
H8                
C
R
L
R
A
V
L
K
S
R
310
               
R
S
S
R
C
G
T
P

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 M L ICL1ECL1 P M ECL1ICL2 T F T H P V F F W L K H ICL2ECL2 R M Y Q N Y L R N H L Q P W N V T G D S I R S Y C E K F Y ECL2ICL3 S G F R ICL3ECL3 P L ECL3N-term M N G D H M V L G S S V N-term T D K K A I I L V T I L L L L R L V A I A G N G F I T A A L G V E W V L R R L P C D K L L V S L G A S R F C L Q S V V M G K T I Y V F L H A F P Y N P V L Q F L A F Q W D F L N A A T L W S S T W L S V F Y C V K I A K L S G W L P W M L F S S V G L S S F T T I L F F I G N H L F P L K M I T W T M P T A V F F I C M I L L I T S L G R H R K K A L L T T E P S V Q A H I K A L L A L L S F A M L F I S Y F L S L V F S A A G I F P D F K F W V W E S V I Y L C A A V H P I I L L F S N C R L K S R C G L R A V R R S S T P
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G A I A V L R L L L L I T V L I I A 1 V S L G A S R F C L Q S V V M G K T I Y 2 W T S S W L T A A N L F D W Q F A L F Q 3 L P W M L F S S V G L S S F T T I L F F 4 M C I F F V A T P M T W T I M K L P F L 5 L L S F A M L F I S Y F L S L V F S A A 6 I P H V A A C L Y I V S E W V W F K F 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

t2r60_human inactive,

t2r60_human active

STRUCTURES

No structures available