TAS1R2 (ts1r2_human)
FAMILY
Class C (Glutamate) Sensory receptors Taste 1 receptors TAS1R2
GENE
TAS1R2 (GPR71, T1R2, TR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Taste receptor type 1 member 2, G-protein coupled receptor 71, Sweet taste receptor T1R2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
P
|
R
|
A
|
K
|
T
|
I
|
S
|
S
|
10 |
L
|
F
|
F
|
L
|
L
|
W
|
V
|
L
|
A
|
E
|
20 |
P
|
A
|
E
|
N
|
S
|
D
|
F
|
Y
|
L
|
P
|
30 |
G
|
D
|
Y
|
L
|
L
|
G
|
G
|
L
|
F
|
S
|
40 |
L
|
H
|
A
|
N
|
M
|
K
|
G
|
I
|
V
|
H
|
50 |
L
|
N
|
F
|
L
|
Q
|
V
|
P
|
M
|
C
|
K
|
60 |
E
|
Y
|
E
|
V
|
K
|
V
|
I
|
G
|
Y
|
N
|
70 |
L
|
M
|
Q
|
A
|
M
|
R
|
F
|
A
|
V
|
E
|
80 |
E
|
I
|
N
|
N
|
D
|
S
|
S
|
L
|
L
|
P
|
90 |
G
|
V
|
L
|
L
|
G
|
Y
|
E
|
I
|
V
|
D
|
100 |
V
|
C
|
Y
|
I
|
S
|
N
|
N
|
V
|
Q
|
P
|
110 |
V
|
L
|
Y
|
F
|
L
|
A
|
H
|
E
|
D
|
N
|
120 |
L
|
L
|
P
|
I
|
Q
|
E
|
D
|
Y
|
S
|
N
|
130 |
Y
|
I
|
S
|
R
|
V
|
V
|
A
|
V
|
I
|
G
|
140 |
P
|
D
|
N
|
S
|
E
|
S
|
V
|
M
|
T
|
V
|
150 |
A
|
N
|
F
|
L
|
S
|
L
|
F
|
L
|
L
|
P
|
160 |
Q
|
I
|
T
|
Y
|
S
|
A
|
I
|
S
|
D
|
E
|
170 |
L
|
R
|
D
|
K
|
V
|
R
|
F
|
P
|
A
|
L
|
180 |
L
|
R
|
T
|
T
|
P
|
S
|
A
|
D
|
H
|
H
|
190 |
I
|
E
|
A
|
M
|
V
|
Q
|
L
|
M
|
L
|
H
|
200 |
F
|
R
|
W
|
N
|
W
|
I
|
I
|
V
|
L
|
V
|
210 |
S
|
S
|
D
|
T
|
Y
|
G
|
R
|
D
|
N
|
G
|
220 |
Q
|
L
|
L
|
G
|
E
|
R
|
V
|
A
|
R
|
R
|
230 |
D
|
I
|
C
|
I
|
A
|
F
|
Q
|
E
|
T
|
L
|
240 |
P
|
T
|
L
|
Q
|
P
|
N
|
Q
|
N
|
M
|
T
|
250 |
S
|
E
|
E
|
R
|
Q
|
R
|
L
|
V
|
T
|
I
|
260 |
V
|
D
|
K
|
L
|
Q
|
Q
|
S
|
T
|
A
|
R
|
270 |
V
|
V
|
V
|
V
|
F
|
S
|
P
|
D
|
L
|
T
|
280 |
L
|
Y
|
H
|
F
|
F
|
N
|
E
|
V
|
L
|
R
|
290 |
Q
|
N
|
F
|
T
|
G
|
A
|
V
|
W
|
I
|
A
|
300 |
S
|
E
|
S
|
W
|
A
|
I
|
D
|
P
|
V
|
L
|
310 |
H
|
N
|
L
|
T
|
E
|
L
|
R
|
H
|
L
|
G
|
320 |
T
|
F
|
L
|
G
|
I
|
T
|
I
|
Q
|
S
|
V
|
330 |
P
|
I
|
P
|
G
|
F
|
S
|
E
|
F
|
R
|
E
|
340 |
W
|
G
|
P
|
Q
|
A
|
G
|
P
|
P
|
P
|
L
|
350 |
S
|
R
|
T
|
S
|
Q
|
S
|
Y
|
T
|
C
|
N
|
360 |
Q
|
E
|
C
|
D
|
N
|
C
|
L
|
N
|
A
|
T
|
370 |
L
|
S
|
F
|
N
|
T
|
I
|
L
|
R
|
L
|
S
|
380 |
G
|
E
|
R
|
V
|
V
|
Y
|
S
|
V
|
Y
|
S
|
390 |
A
|
V
|
Y
|
A
|
V
|
A
|
H
|
A
|
L
|
H
|
400 |
S
|
L
|
L
|
G
|
C
|
D
|
K
|
S
|
T
|
C
|
410 |
T
|
K
|
R
|
V
|
V
|
Y
|
P
|
W
|
Q
|
L
|
420 |
L
|
E
|
E
|
I
|
W
|
K
|
V
|
N
|
F
|
T
|
430 |
L
|
L
|
D
|
H
|
Q
|
I
|
F
|
F
|
D
|
P
|
440 |
Q
|
G
|
D
|
V
|
A
|
L
|
H
|
L
|
E
|
I
|
450 |
V
|
Q
|
W
|
Q
|
W
|
D
|
R
|
S
|
Q
|
N
|
460 |
P
|
F
|
Q
|
S
|
V
|
A
|
S
|
Y
|
Y
|
P
|
470 |
L
|
Q
|
R
|
Q
|
L
|
K
|
N
|
I
|
Q
|
D
|
480 |
I
|
S
|
W
|
H
|
T
|
I
|
N
|
N
|
T
|
I
|
490 |
P
|
M
|
S
|
M
|
C
|
S
|
K
|
R
|
C
|
Q
|
500 |
S
|
G
|
Q
|
K
|
K
|
K
|
P
|
V
|
G
|
I
|
510 |
H
|
V
|
C
|
C
|
F
|
E
|
C
|
I
|
D
|
C
|
520 |
L
|
P
|
G
|
T
|
F
|
L
|
N
|
H
|
T
|
E
|
530 |
D
|
E
|
Y
|
E
|
C
|
Q
|
A
|
C
|
P
|
N
|
540 |
N
|
E
|
W
|
S
|
Y
|
Q
|
S
|
E
|
T
|
S
|
550 |
C
|
F
|
K
|
R
|
Q
|
L
|
V
|
F
|
L
|
E
|
560 |
TM1 | |||||||||
W
|
H
|
E
|
A
|
P
|
T
|
I
|
A
|
V
|
A
|
570 |
L
|
L
|
A
|
A
|
L
|
G
|
F
|
L
|
S
|
T
|
580 |
L
|
A
|
I
|
L
|
V
|
I
|
F
|
W
|
R
|
H
|
590 |
ICL1 | |||||||||
F
|
Q
|
T
|
P
|
I
|
V
|
R
|
S
|
A
|
G
|
600 |
TM2 | |||||||||
G
|
P
|
M
|
C
|
F
|
L
|
M
|
L
|
T
|
L
|
610 |
L
|
L
|
V
|
A
|
Y
|
M
|
V
|
V
|
P
|
V
|
620 |
ECL1 | TM3 | ||||||||
Y
|
V
|
G
|
P
|
P
|
K
|
V
|
S
|
T
|
C
|
630 |
L
|
C
|
R
|
Q
|
A
|
L
|
F
|
P
|
L
|
C
|
640 |
F
|
T
|
I
|
C
|
I
|
S
|
C
|
I
|
A
|
V
|
650 |
R
|
S
|
F
|
Q
|
I
|
V
|
C
|
A
|
F
|
K
|
660 |
ICL2 | |||||||||
M
|
A
|
S
|
R
|
F
|
P
|
R
|
A
|
Y
|
S
|
670 |
TM4 | |||||||||
Y
|
W
|
V
|
R
|
Y
|
Q
|
G
|
P
|
Y
|
V
|
680 |
S
|
M
|
A
|
F
|
I
|
T
|
V
|
L
|
K
|
M
|
690 |
V
|
I
|
V
|
V
|
I
|
G
|
M
|
L
|
A
|
T
|
700 |
ECL2 | |||||||||
G
|
L
|
S
|
P
|
T
|
T
|
R
|
T
|
D
|
P
|
710 |
D
|
D
|
P
|
K
|
I
|
T
|
I
|
V
|
S
|
C
|
720 |
TM5 | |||||||||
N
|
P
|
N
|
Y
|
R
|
N
|
S
|
L
|
L
|
F
|
730 |
N
|
T
|
S
|
L
|
D
|
L
|
L
|
L
|
S
|
V
|
740 |
V
|
G
|
F
|
S
|
F
|
A
|
Y
|
M
|
G
|
K
|
750 |
ICL3 | TM6 | ||||||||
E
|
L
|
P
|
T
|
N
|
Y
|
N
|
E
|
A
|
K
|
760 |
F
|
I
|
T
|
L
|
S
|
M
|
T
|
F
|
Y
|
F
|
770 |
T
|
S
|
S
|
V
|
S
|
L
|
C
|
T
|
F
|
M
|
780 |
ECL3 | TM7 | ||||||||
S
|
A
|
Y
|
S
|
G
|
V
|
L
|
V
|
T
|
I
|
790 |
V
|
D
|
L
|
L
|
V
|
T
|
V
|
L
|
N
|
L
|
800 |
L
|
A
|
I
|
S
|
L
|
G
|
Y
|
F
|
G
|
P
|
810 |
H8 | |||||||||
K
|
C
|
Y
|
M
|
I
|
L
|
F
|
Y
|
P
|
E
|
820 |
R
|
N
|
T
|
P
|
A
|
Y
|
F
|
N
|
S
|
M
|
830 |
C-term | ||||||||
I
|
Q
|
G
|
Y
|
T
|
M
|
R
|
R
|
D
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available