glucagon receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6WPW

RESOLUTION

3.1 Å

REFERENCE

10.1126/SCIENCE.ABA3373

PUBLICATION DATE

Aug. 12, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

132 interactions (Click to see)

LIGANDS

Glucagon derivative ZP3780 - Agonist

ENDOGENOUS LIGANDS

glucagon



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 336 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 256 - G.H5 F 376 G.H5.08
Polar TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 332 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 332 5x64 G.H5 R 385 G.H5.17
Polar ICL3 R 336 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 R 336 - G.S6 C 359 G.S6.01
Hydrophobic TM5 L 329 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 329 5x61 G.H5 L 388 G.H5.20
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals ICL4 L 403 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 E 260 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 T 257 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 329 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 329 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 332 5x64 G.H5 L 394 G.H5.26
Polar TM6 S 350 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 350 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 350 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 325 5x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 T 257 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 T 257 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 E 260 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 E 260 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 258 - G.H5 I 383 G.H5.15
Polar TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 354 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 336 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 R 336 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL2 G 254 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 257 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 333 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 328 5x60 G.H5 Q 384 G.H5.16
Polar TM6 R 346 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 346 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 346 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 256 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 A 256 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 261 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 261 - G.HN Q 35 G.HN.52
Aromatic ICL3 R 336 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 R 336 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 R 336 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 L 258 - G.H5 M 386 G.H5.18
Hydrophobic TM5 L 328 5x60 G.H5 L 388 G.H5.20
Van-der-waals TM3 Y 248 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 329 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL2 T 257 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 257 - G.S3 V 217 G.S3.01
Hydrophobic H8 N 404 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Polar ICL3 H 339 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 H 339 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 H 339 - G.h4s6 T 350 G.h4s6.03
Polar TM3 L 252 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 252 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 252 3x57 G.H5 H 387 G.H5.19
Polar ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 258 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 T 353 6x44 G.H5 L 393 G.H5.25
Polar H8 K 405 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 405 8x48 G.H5 E 392 G.H5.24
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 A 256 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 256 - G.H5 R 380 G.H5.12
Polar ICL2 A 256 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 256 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 256 - G.S1 H 41 G.S1.02
Ionic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 253 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 253 3x58 G.H5 L 388 G.H5.20