GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CFM

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-020-2569-1

PUBLICATION DATE

Sept. 9, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

38 interactions (Click to see)

LIGANDS

CHEMBL2331646 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
T09G.hgh4R12D13Q16Q22E24L26G.H5GproteinL3x55R-V3x54Q5x68R-Q6x33GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hgh4G.H5GPCR segments:TM3ICL3TM5TM6C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x543x555x615x625x645x655x685x715x725x755x765x796x256x296x326x336x36G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.S6.03G.h4s6.20G.h4s6.11G.h4s6.10G.h4s6.03G.H4.17G.H4.16G.hgh4.09G.S3.01G.S1.02Res. Pos.GPBA (7CFM)- (7CFM)----------------------AERAVLVLTAQDILEVLLRQAAERAVLVLTAQDILEVLLRQALYHQLRLDRLYLPTRDGEFIQHVT

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.