D1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CKX

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

March 3, 2021

3D VIEW

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LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

A77636 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline, 5-hydroxytryptamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 227 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 227 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 231 5x75 G.H4 L 346 G.H4.16
Van-der-waals TM5 L 231 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 125 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 R 227 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 227 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 235 5x79 G.H4 R 347 G.H4.17
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 S 127 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM5 Q 224 5x68 G.H5 L 388 G.H5.20
Aromatic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 A 221 5x65 G.H5 L 388 G.H5.20
Polar TM6 T 273 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 273 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 273 6x36 G.H5 E 392 G.H5.24
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 L 231 5x75 G.S6 P 361 G.S6.03
Hydrophobic ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 E 232 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 235 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 A 235 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM5 I 217 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 217 5x61 G.H5 L 393 G.H5.25
Polar H8 N 334 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 N 334 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 334 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 Q 224 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 231 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 L 231 5x75 G.S6 C 359 G.S6.01
Hydrophobic ICL2 R 133 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals TM5 L 231 5x75 G.H4 R 342 G.H4.12
Polar TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM6 V 270 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Polar TM3 S 126 3x55 G.H5 Q 384 G.H5.16
Van-der-waals TM3 S 126 3x55 G.H5 Q 384 G.H5.16
Van-der-waals TM4 P 137 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 T 273 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 273 6x36 G.H5 L 393 G.H5.25
Polar ICL1 S 56 12x52 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 S 56 12x52 G.hns1 R 38 G.hns1.02
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 274 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals TM2 K 57 2x37 G.hns1 R 38 G.hns1.02
Aromatic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Polar TM3 S 126 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 S 126 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 S 126 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 129 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 A 234 5x78 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 234 5x78 G.H4 D 343 G.H4.13
Polar TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Polar TM5 A 235 5x79 G.H4 D 343 G.H4.13
Polar TM6 R 266 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 266 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 I 225 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 225 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 228 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 228 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 E 132 34x54 G.hns1 A 39 G.hns1.03
Polar TM5 Q 224 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 224 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 224 5x68 G.H5 D 381 G.H5.13
Polar TM6 R 266 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 266 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 266 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 237 5x81 G.hgh4 P 321 G.hgh4.11
Ionic TM6 K 269 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 269 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 269 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 269 6x32 G.H5 E 392 G.H5.24
Ionic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 388 G.H5.20
Polar TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 131 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 131 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM4 P 137 4x39 G.HN K 34 G.HN.51