EP2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CX2

RESOLUTION

2.8 Å

REFERENCE

10.1126/SCIADV.ABF1268

PUBLICATION DATE

May 5, 2021

3D VIEW

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LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

PGE2 - Agonist pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem

PHYSIOLOGICAL LIGANDS

PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1H02G.S1Y20G.h4s6F08R12Q16R17H19Q22Y23E24G.H5GproteinE3x49G3x55Y34x53E6x29R8x47E6x30F2x39M5x66S4x38S5x70Y34x51R34x55Q34x54I3x54GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S1G.h4s6G.H5GPCR segments:TM2ICL2TM3TM4TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
2x372x393x493x503x533x543x5534x5034x5134x5334x5434x5534x574x385x635x665x695x706x296x306x338x478x488x49G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.h4s6.20G.S3.01G.S1.02G.hns1.02Res. Pos.EP2 (7CX2)- (7CX2)------------------------SFERSIGPYYQRVSLMRSEEHRPPSFPYYQRVERSIGSLMRSEEHRPPQYRIQHFCHVRLRDRYEL

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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