GHRH receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CZ5

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41467-020-18945-0

PUBLICATION DATE

Nov. 18, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

72 interactions (Click to see)

LIGANDS

Somatoliberin - Agonist pubchem

ENDOGENOUS LIGANDS

GHRH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Polar TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Polar H8 N 380 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 380 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 380 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 307 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 311 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 311 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 S 237 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 307 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Polar TM3 S 233 3x60 G.H5 R 380 G.H5.12
Van-der-waals TM3 S 233 3x60 G.H5 R 380 G.H5.12
Hydrophobic TM5 K 310 5x64 G.H5 L 394 G.H5.26
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 227 3x54 G.H5 L 393 G.H5.25
Polar TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 R 385 G.H5.17
Polar TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Polar TM6 R 326 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 326 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 326 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 334 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 T 234 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 T 234 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 307 5x61 G.H5 L 388 G.H5.20
Polar TM6 R 326 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 326 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Polar TM3 L 231 3x58 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 236 - G.S1 H 41 G.S1.02
Hydrophobic TM6 R 326 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 T 234 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 234 - G.H5 R 380 G.H5.12
Polar H8 Q 381 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 381 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Polar TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 235 - G.S3 V 217 G.S3.01
Hydrophobic TM5 K 310 5x64 G.H5 L 388 G.H5.20
Ionic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 310 5x64 G.H5 D 381 G.H5.13