GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7E14

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-021-24058-Z

PUBLICATION DATE

July 7, 2021

3D VIEW

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LIGAND INTERACTIONS

57 interactions (Click to see)

LIGANDS

N-Tert-butyl-6,7-dichloroquinoxalin-2-amine - Ago-PAM pubchem ,

orforglipron - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 1-(7-37), glucagon, glucagon-like peptide 1-(7-36) amide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
K51G.HNQ22E24L25L26G.H5GproteinR6x37E4x39N8x47R2x46N8x48GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.H5GPCR segments:TM2TM4TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x463x493x503x533x544x394x405x615x645x655x685x696x326x356x366x406x437x538x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.13G.S3.01G.hns1.03G.hns1.02G.HN.52G.HN.51G.HN.48Res. Pos.GLP-1 (7E14)- (7E14)----------------------REYLLLEQVIVKLRKSLLYNNREYLLLEQVIVKLRKSLLYNNSQYLHQLKRQQLDREVA

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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