CCR5 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F1S

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-021-24438-5

PUBLICATION DATE

July 14, 2021

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

CCL11, CCL14, CCL2, CCL8, CCL5, CCL16, CCL4, CCL13, CCL7, CCL3



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 130 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 I 344 G.H5.16
Ionic TM5 R 223 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 223 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 223 5x67 G.H5 D 341 G.H5.13
Polar TM6 R 232 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 E 302 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 A 133 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 133 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 133 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 A 133 34x50 G.H5 T 340 G.H5.12
Polar TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 347 G.H5.19
Polar TM5 C 224 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 C 224 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 C 224 5x68 G.H5 K 345 G.H5.17
Polar TM6 R 232 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 232 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 233 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 233 6x33 G.H5 F 354 G.H5.26
Polar ICL2 R 140 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 221 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 137 34x54 G.H5 I 343 G.H5.15
Polar ICL3 R 225 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 R 225 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 225 - G.S6 I 319 G.S6.01
Hydrophobic TM4 T 141 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 141 4x38 G.hns1 R 32 G.hns1.03
Aromatic ICL3 R 225 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 225 - G.S6 Y 320 G.S6.02
Polar H8 E 302 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 302 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 302 8x48 G.H5 F 354 G.H5.26
Polar ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 V 300 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 300 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 134 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 134 34x51 G.H5 F 336 G.H5.08
Hydrophobic H8 G 301 8x47 G.H5 F 354 G.H5.26
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 351 G.H5.23
Aromatic TM6 K 229 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 229 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 229 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM7 V 300 7x56 G.H5 F 354 G.H5.26
Polar H8 G 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 130 3x54 G.H5 L 348 G.H5.20
Polar ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 133 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 223 5x67 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 223 5x67 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 I 237 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 129 3x53 G.H5 C 351 G.H5.23
Polar TM6 N 226 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 226 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 353 G.H5.25