B2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F2O

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41594-021-00645-Y

PUBLICATION DATE

Oct. 13, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

61 interactions (Click to see)

LIGANDS

bradykinin - Agonist pubchem gtoplig chembl_ligand drugbank gtoplig

PHYSIOLOGICAL LIGANDS

T-kinin, kallidin, Lys-[Hyp3]-bradykinin, bradykinin, [des-Arg10]kallidin, [Hyp3]bradykinin, [des-Arg9]bradykinin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R03G.hns1R21Y23N24G.H5GproteinR8x49G-V3x46G8x47Y7x53GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL2TM3TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
Res. Pos.

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.