LH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

7FIH

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41586-021-03924-2

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

45 interactions (Click to see)

LIGANDS

5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide - Allosteric agonist pubchem ,

Choriogonadotropin beta - Agonist gtoplig ,

Glycoprotein alpha - Agonist gtoplig

ENDOGENOUS LIGANDS

hCG, LH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 563 6x29 G.h4s6 Y 348 G.h4s6.20
Polar TM3 E 463 3x49 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 H 473 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 474 - G.S1 H 41 G.S1.02
Hydrophobic TM6 K 570 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 K 570 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM2 P 394 2x39 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 A 471 - G.H5 H 377 G.H5.19
Hydrophobic TM3 I 468 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 I 468 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL2 I 472 - G.S3 F 219 G.S3.03
Polar TM6 K 570 6x36 G.H5 Y 381 G.H5.23
Van-der-waals TM6 K 570 6x36 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 474 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 474 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 I 472 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 I 472 - G.H5 F 366 G.H5.08
Hydrophobic TM5 V 553 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 V 553 5x65 G.H5 L 378 G.H5.20
Polar TM3 T 467 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM3 T 467 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 T 467 3x53 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 I 472 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 468 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL3 L 558 - G.S6 Y 350 G.S6.02
Polar TM3 I 468 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 468 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 468 3x54 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 K 477 - G.H5 H 377 G.H5.19
Hydrophobic TM6 M 571 6x37 G.H5 L 383 G.H5.25
Hydrophobic ICL2 I 472 - G.H5 R 370 G.H5.12
Polar ICL2 I 472 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 I 472 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 472 - G.S1 H 41 G.S1.02
Hydrophobic TM3 I 468 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 I 468 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM6 K 563 6x29 G.H5 L 384 G.H5.26
Hydrophobic TM6 I 567 6x33 G.H5 L 378 G.H5.20
Van-der-waals TM6 I 567 6x33 G.H5 L 378 G.H5.20
Hydrophobic TM6 I 567 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 I 567 6x33 G.H5 L 383 G.H5.25
Polar TM3 T 469 3x55 G.H5 Q 374 G.H5.16
Polar H8 K 628 8x48 G.H5 E 382 G.H5.24
Hydrophobic H8 K 628 8x48 G.H5 E 382 G.H5.24
Van-der-waals H8 K 628 8x48 G.H5 E 382 G.H5.24
Hydrophobic TM5 I 549 5x61 G.H5 L 383 G.H5.25
Polar H8 T 627 8x47 G.H5 E 382 G.H5.24
Hydrophobic H8 T 627 8x47 G.H5 E 382 G.H5.24
Van-der-waals H8 T 627 8x47 G.H5 E 382 G.H5.24
Polar TM6 K 570 6x36 G.H5 E 382 G.H5.24
Hydrophobic TM6 K 570 6x36 G.H5 E 382 G.H5.24
Van-der-waals TM6 K 570 6x36 G.H5 E 382 G.H5.24
Aromatic TM3 R 464 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 464 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 D 475 - G.hns1 A 39 G.hns1.03
Polar ICL3 N 555 - G.H5 R 375 G.H5.17
Van-der-waals ICL3 N 555 - G.H5 R 375 G.H5.17
Hydrophobic TM6 I 567 6x33 G.H5 L 384 G.H5.26
Van-der-waals TM6 I 567 6x33 G.H5 L 384 G.H5.26
Hydrophobic ICL2 I 472 - G.H5 C 369 G.H5.11
Hydrophobic ICL2 A 471 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 A 471 - G.H5 I 373 G.H5.15
Van-der-waals TM4 R 479 4x38 G.hns1 R 38 G.hns1.02
Polar ICL3 N 555 - G.H5 D 371 G.H5.13
Hydrophobic ICL3 N 555 - G.H5 D 371 G.H5.13
Van-der-waals ICL3 N 555 - G.H5 D 371 G.H5.13
Hydrophobic ICL2 A 471 - G.H5 Q 374 G.H5.16
Van-der-waals ICL2 A 471 - G.H5 Q 374 G.H5.16