LH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide - Allosteric agonist pubchem ,

Choriogonadotropin beta - Agonist gtoplig ,

Glycoprotein alpha - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

LH, hCG



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
Q16R17G.H5GproteinN-T3x55GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H5GPCR segments:TM3ICL3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x543x554x385x615x656x296x336x366x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.S6.02G.h4s6.20G.S3.03G.S3.01G.S1.02G.hns1.03G.hns1.02Res. Pos.LH (7FIH)- (7FIH)----------------PERTITRIVKIKMTKPERTITRIVKIKMTKIYQHLRLLYEFCRDIRHVFYA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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