CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.0 Å

REFERENCE

PUBLICATION DATE

May 26, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CHEMBL216166 - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

CCK-58, CCK-39, CCK-8, CCK-4, gastrin-17, CCK-33, desulfated cholecystokinin-8



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 147 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 146 34x50 G.H5 Q 384 G.H5.16
Polar H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic H8 K 375 8x48 G.H5 L 393 G.H5.25
Van-der-waals H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Polar H8 R 378 8x51 G.H5 L 393 G.H5.25
Van-der-waals H8 R 378 8x51 G.H5 L 393 G.H5.25
Polar ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.S3 F 219 G.S3.03
Polar ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 S 301 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic H8 R 376 8x49 G.H5 R 389 G.H5.21
Polar TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Polar ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Ionic TM5 E 235 5x64 G.H5 R 380 G.H5.12
Polar TM5 E 235 5x64 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM7 M 373 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 M 373 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM6 M 314 6x36 G.H5 L 393 G.H5.25
Polar ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Polar ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM6 K 308 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 146 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 146 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM6 V 311 6x33 G.H5 L 388 G.H5.20
Hydrophobic H8 K 375 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL2 R 150 34x54 G.H5 I 383 G.H5.15
Van-der-waals H8 N 374 8x47 G.H5 E 392 G.H5.24
Polar TM3 C 144 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 144 3x55 G.H5 R 380 G.H5.12
Polar H8 N 374 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 374 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 Q 390 G.H5.22
Polar H8 K 375 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 375 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 375 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 147 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 147 34x51 G.H5 C 379 G.H5.11
Polar ICL3 S 301 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 S 301 - G.h4s6 G 355 G.h4s6.11