MC4 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7PIU

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41422-021-00569-8

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

setmelanotide - Agonist pubchem gtoplig drug_central chembl_ligand drugbank

ENDOGENOUS LIGANDS

agouti-related protein, β-MSH, α-MSH, γ-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 215 5x61 G.H5 L 379 G.H5.25
Van-der-waals TM5 M 215 5x61 G.H5 L 379 G.H5.25
Hydrophobic TM5 M 218 5x64 G.H5 Q 370 G.H5.16
Hydrophobic TM5 F 216 5x62 G.H5 L 379 G.H5.25
Van-der-waals TM5 F 216 5x62 G.H5 L 379 G.H5.25
Hydrophobic ICL2 N 159 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 N 159 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 H 158 34x54 G.hns1 A 39 G.hns1.03
Polar TM2 Y 80 2x40 G.H5 Q 376 G.H5.22
Hydrophobic TM5 H 222 5x68 G.H5 L 374 G.H5.20
Van-der-waals TM5 H 222 5x68 G.H5 L 374 G.H5.20
Hydrophobic TM5 A 219 5x65 G.H5 L 380 G.H5.26
Van-der-waals TM5 A 219 5x65 G.H5 L 380 G.H5.26
Hydrophobic TM4 T 162 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 162 4x38 G.HN Q 35 G.HN.52
Ionic TM5 R 225 5x71 G.H5 D 367 G.H5.13
Polar TM5 R 225 5x71 G.H5 D 367 G.H5.13
Hydrophobic TM5 R 225 5x71 G.H5 D 367 G.H5.13
Van-der-waals TM5 R 225 5x71 G.H5 D 367 G.H5.13
Polar ICL3 P 230 - G.h4s6 T 336 G.h4s6.03
Van-der-waals ICL3 P 230 - G.h4s6 T 336 G.h4s6.03
Hydrophobic ICL2 L 155 34x51 G.H5 I 369 G.H5.15
Hydrophobic TM5 I 226 5x72 G.H5 R 371 G.H5.17
Van-der-waals TM5 I 226 5x72 G.H5 R 371 G.H5.17
Hydrophobic ICL3 L 229 - G.H4 L 332 G.H4.16
Hydrophobic TM5 I 226 5x72 G.H5 L 380 G.H5.26
Hydrophobic TM6 L 247 6x37 G.H5 L 379 G.H5.25
Hydrophobic ICL2 L 155 34x51 G.H5 R 366 G.H5.12
Polar TM6 T 246 6x36 G.H5 Y 377 G.H5.23
Polar TM5 H 222 5x68 G.H5 R 371 G.H5.17
Hydrophobic TM5 H 222 5x68 G.H5 R 371 G.H5.17
Hydrophobic TM5 H 222 5x68 G.H5 L 380 G.H5.26
Hydrophobic ICL2 A 154 34x50 G.H5 R 366 G.H5.12
Hydrophobic TM3 I 151 3x54 G.H5 H 373 G.H5.19
Hydrophobic TM6 T 246 6x36 G.H5 L 379 G.H5.25
Hydrophobic TM5 I 226 5x72 G.h4s6 Y 344 G.h4s6.20
Van-der-waals TM5 I 226 5x72 G.h4s6 Y 344 G.h4s6.20
Hydrophobic TM3 I 151 3x54 G.H5 L 374 G.H5.20
Hydrophobic ICL2 A 154 34x50 G.H5 Q 370 G.H5.16
Polar TM3 T 150 3x53 G.H5 Y 377 G.H5.23
Van-der-waals TM3 T 150 3x53 G.H5 Y 377 G.H5.23
Hydrophobic TM6 T 246 6x36 G.H5 E 378 G.H5.24
Van-der-waals TM6 T 246 6x36 G.H5 E 378 G.H5.24
Polar TM3 I 151 3x54 G.H5 Q 370 G.H5.16
Hydrophobic TM3 I 151 3x54 G.H5 Q 370 G.H5.16
Van-der-waals TM3 I 151 3x54 G.H5 Q 370 G.H5.16
Hydrophobic ICL3 L 229 - G.h4s6 T 336 G.h4s6.03
Hydrophobic TM2 M 79 2x39 G.H5 Y 377 G.H5.23
Van-der-waals TM2 M 79 2x39 G.H5 Y 377 G.H5.23
Hydrophobic TM6 K 242 6x32 G.H5 E 378 G.H5.24
Hydrophobic TM5 A 219 5x65 G.H5 L 379 G.H5.25
Hydrophobic TM3 I 151 3x54 G.H5 Y 377 G.H5.23
Van-der-waals TM3 I 151 3x54 G.H5 Y 377 G.H5.23
Aromatic TM3 R 147 3x50 G.H5 Y 377 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 Y 377 G.H5.23
Polar TM6 G 243 6x33 G.H5 L 379 G.H5.25
Hydrophobic TM6 G 243 6x33 G.H5 L 379 G.H5.25
Van-der-waals TM6 G 243 6x33 G.H5 L 379 G.H5.25
Hydrophobic ICL2 A 154 34x50 G.H5 I 369 G.H5.15
Van-der-waals ICL2 A 154 34x50 G.H5 I 369 G.H5.15
Hydrophobic ICL2 L 155 34x51 G.S3 V 203 G.S3.01
Hydrophobic ICL3 P 230 - G.H4 D 329 G.H4.13
Hydrophobic ICL3 P 230 - G.H4 L 332 G.H4.16
Van-der-waals ICL3 P 230 - G.H4 L 332 G.H4.16
Hydrophobic TM3 T 150 3x53 G.H5 H 373 G.H5.19
Hydrophobic ICL2 Q 156 34x52 G.S3 V 203 G.S3.01
Hydrophobic TM5 A 219 5x65 G.H5 L 374 G.H5.20
Hydrophobic TM5 H 222 5x68 G.H5 D 367 G.H5.13
Ionic TM7 R 305 7x56 G.H5 E 378 G.H5.24
Polar TM7 R 305 7x56 G.H5 E 378 G.H5.24
Hydrophobic TM7 R 305 7x56 G.H5 E 378 G.H5.24
Van-der-waals TM7 R 305 7x56 G.H5 E 378 G.H5.24
Polar ICL2 L 155 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 155 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 155 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 H 158 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 158 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 M 218 5x64 G.H5 L 374 G.H5.20
Hydrophobic ICL2 L 155 34x51 G.H5 F 362 G.H5.08
Van-der-waals ICL2 L 155 34x51 G.H5 F 362 G.H5.08
Polar TM5 H 222 5x68 G.H5 Q 370 G.H5.16
Hydrophobic TM5 H 222 5x68 G.H5 Q 370 G.H5.16
Van-der-waals TM5 H 222 5x68 G.H5 Q 370 G.H5.16
Hydrophobic TM5 I 223 5x69 G.H5 L 380 G.H5.26
Van-der-waals TM5 I 223 5x69 G.H5 L 380 G.H5.26
Hydrophobic ICL2 L 155 34x51 G.H5 C 365 G.H5.11