US28 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Human cytomegalovirus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

Jan. 26, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Fractalkine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 M 136 - G.hns1 A 30 G.hns1.01
Hydrophobic TM5 V 217 5x67 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 Y 135 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic H8 K 297 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 K 297 8x49 G.H5 F 354 G.H5.26
Polar ICL2 Y 138 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 Y 138 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 138 - G.H5 D 350 G.H5.22
Hydrophobic H8 G 295 8x47 G.H5 L 353 G.H5.25
Van-der-waals H8 G 295 8x47 G.H5 L 353 G.H5.25
Hydrophobic TM3 Y 135 3x56 G.HN G 27 G.HN.51
Polar H8 T 296 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 T 296 8x48 G.H5 L 353 G.H5.25
Polar H8 K 297 8x49 G.H5 G 352 G.H5.24
Hydrophobic H8 K 297 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 K 297 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 132 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 A 132 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM7 V 294 7x56 G.H5 L 353 G.H5.25
Polar TM3 V 134 3x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 215 5x65 G.H5 N 347 G.H5.19
Polar TM3 Y 135 3x56 G.HN R 24 G.HN.48
Ionic TM5 R 210 5x60 G.HN E 28 G.HN.52
Polar TM5 R 210 5x60 G.HN E 28 G.HN.52
Van-der-waals TM5 R 210 5x60 G.HN E 28 G.HN.52
Hydrophobic TM6 R 225 6x32 G.H5 L 353 G.H5.25
Van-der-waals ICL2 M 136 - G.S1 K 35 G.S1.03
Hydrophobic TM3 Y 135 3x56 G.HN E 28 G.HN.52
Van-der-waals TM3 Y 135 3x56 G.HN E 28 G.HN.52
Hydrophobic TM3 I 133 3x54 G.H5 N 347 G.H5.19
Hydrophobic H8 K 297 8x49 G.H5 K 349 G.H5.21
Polar H8 K 297 8x49 G.H5 L 353 G.H5.25
Van-der-waals H8 K 297 8x49 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 134 3x55 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 V 134 3x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 S 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 229 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 136 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 M 136 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 Q 219 - G.H5 F 336 G.H5.08
Van-der-waals ICL3 Q 219 - G.H5 F 336 G.H5.08
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 C 351 G.H5.23
Polar H8 T 296 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 T 296 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 T 296 8x48 G.H5 F 354 G.H5.26
Polar TM3 I 133 3x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 133 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 133 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 214 5x64 G.hns1 R 32 G.hns1.03
Van-der-waals TM5 I 214 5x64 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 Q 219 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL3 Q 219 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 I 226 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 I 226 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 226 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 223 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM6 H 222 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 222 6x29 G.H5 I 344 G.H5.16
Hydrophobic H8 F 298 8x50 G.H5 G 352 G.H5.24
Van-der-waals H8 F 298 8x50 G.H5 G 352 G.H5.24
Hydrophobic ICL3 S 220 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 S 220 - G.H5 I 344 G.H5.16