NK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Nov. 3, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

substance P - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

PHYSIOLOGICAL LIGANDS

neuropeptide-γ, hemokinin 1, neurokinin A, neuropeptide K, neurokinin B, substance P



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
H02G.S1R12H19G.H5GproteinP-I3x55L-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S1G.H5GPCR segments:ICL2TM3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x403x493x503x533x543x555x656x296x336x367x568x478x50G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.11G.H5.08G.h4s6.20G.S3.03G.S3.01G.S1.02Res. Pos.NK1 (7RMH)- (7RMH)---------------TNDRAIILAVMLNFTNDRAIILAVMLNFLYELQLRLFCIRHHVFY

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.