OT receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

O

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

March 9, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

vasopressin, oxytocin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM2 L 74 2x39 G.H5 Y 1243 G.H5.23
Hydrophobic ICL2 L 145 - G.H5 K 1232 G.H5.12
Van-der-waals ICL2 L 145 - G.H5 K 1232 G.H5.12
Polar TM7 F 332 7x56 G.H5 N 1244 G.H5.24
Van-der-waals TM7 F 332 7x56 G.H5 N 1244 G.H5.24
Hydrophobic ICL2 P 144 - G.H5 L 1236 G.H5.16
Polar TM6 R 272 6x32 G.H5 N 1244 G.H5.24
Van-der-waals TM6 R 272 6x32 G.H5 N 1244 G.H5.24
Hydrophobic TM3 A 140 3x53 G.H5 Y 1243 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 Y 1243 G.H5.23
Hydrophobic TM3 I 141 3x54 G.H5 L 1245 G.H5.25
Van-der-waals TM3 I 141 3x54 G.H5 L 1245 G.H5.25
Hydrophobic ICL2 L 145 - G.H5 F 1228 G.H5.08
Van-der-waals ICL2 L 145 - G.H5 F 1228 G.H5.08
Hydrophobic ICL1 R 73 - G.H5 Y 1243 G.H5.23
Hydrophobic TM5 I 227 5x65 G.H5 L 1245 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 L 1240 G.H5.20
Hydrophobic TM6 M 276 6x36 G.H5 L 1245 G.H5.25
Hydrophobic ICL2 P 144 - G.H5 I 1235 G.H5.15
Hydrophobic TM5 I 227 5x65 G.H5 L 1240 G.H5.20
Polar TM3 A 140 3x53 G.H5 N 1239 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 1239 G.H5.19
Polar TM5 N 230 5x68 G.H5 Q 1237 G.H5.17
Van-der-waals TM5 N 230 5x68 G.H5 Q 1237 G.H5.17
Polar TM3 R 137 3x50 G.H5 Y 1243 G.H5.23
Hydrophobic ICL2 L 145 - G.H5 I 1235 G.H5.15
Van-der-waals ICL2 L 145 - G.H5 I 1235 G.H5.15
Hydrophobic TM5 I 223 5x61 G.H5 L 1245 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 1245 G.H5.25
Van-der-waals H8 T 333 8x47 G.H5 N 1244 G.H5.24