MRGPRX2 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.5 Å

REFERENCE

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Cortistatin 14 - Agonist pubchem

ENDOGENOUS LIGANDS

PAMP-20



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 R 127 3x50 G.H5 L 245 G.H5.25
Polar ICL2 R 138 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 R 138 34x54 G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 135 34x51 G.H5 K 232 G.H5.12
Van-der-waals ICL2 I 135 34x51 G.H5 K 232 G.H5.12
Hydrophobic ICL2 I 135 34x51 G.H5 I 235 G.H5.15
Polar TM3 E 126 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 126 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 E 126 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 C 139 34x55 G.S1 L 34 G.S1.02
Polar ICL2 R 141 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 141 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 138 34x54 G.H5 I 235 G.H5.15
Polar ICL2 C 139 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 139 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 R 220 6x32 G.H5 L 245 G.H5.25
Van-der-waals TM6 R 220 6x32 G.H5 L 245 G.H5.25
Polar TM6 L 221 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 L 221 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 221 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 135 34x51 G.H5 F 228 G.H5.08
Hydrophobic TM7 G 283 7x57 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 134 34x50 G.H5 L 236 G.H5.16
Polar ICL2 R 138 34x54 G.H5 M 238 G.H5.18
Hydrophobic ICL2 R 138 34x54 G.H5 M 238 G.H5.18
Van-der-waals ICL2 R 138 34x54 G.H5 M 238 G.H5.18
Hydrophobic TM3 V 131 3x54 G.H5 L 240 G.H5.20
Polar ICL2 R 138 34x54 G.hns1 R 31 G.hns1.02
Polar TM6 R 220 6x32 G.H5 N 244 G.H5.24
Hydrophobic TM6 T 224 6x36 G.H5 L 245 G.H5.25
Polar TM3 S 130 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 P 134 34x50 G.H5 I 235 G.H5.15
Polar ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 140 34x56 G.hns1 R 32 G.hns1.03
Aromatic TM2 F 64 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM2 F 64 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 F 64 2x39 G.H5 Y 243 G.H5.23
Polar ICL2 P 134 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 134 34x50 G.H5 N 239 G.H5.19
Polar ICL2 Y 137 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 137 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 Y 137 34x53 G.H5 Y 243 G.H5.23