μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SCG

RESOLUTION

3.0 Å

REFERENCE

10.1002/ANIE.202200269

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

31 interactions (Click to see)

LIGANDS

(2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide - Agonist pubchem

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 176 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 168 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 103 2x39 G.H5 C 351 G.H5.23
Polar ICL3 R 263 - G.S6 I 319 G.S6.01
Hydrophobic H8 E 341 8x48 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 264 - G.H5 V 342 G.H5.14
Polar TM3 A 168 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 168 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 168 3x53 G.H5 N 347 G.H5.19
Hydrophobic H8 E 341 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 341 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 173 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 165 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM4 R 182 4x40 G.HN R 24 G.HN.48
Hydrophobic TM5 R 258 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 258 5x64 G.H5 I 344 G.H5.16
Polar ICL3 R 263 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 264 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 264 - G.H5 K 345 G.H5.17
Hydrophobic TM6 I 278 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 173 34x51 G.S3 L 194 G.S3.01
Polar H8 N 342 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 176 34x54 G.S3 L 194 G.S3.01
Polar TM2 T 103 2x39 G.H5 D 350 G.H5.22
Ionic ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 176 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 265 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 265 - G.H5 F 354 G.H5.26
Polar TM6 R 277 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 172 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 172 34x50 G.H5 I 343 G.H5.15
Polar ICL2 R 179 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 179 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 179 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 169 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 169 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 D 340 8x47 G.H5 G 352 G.H5.24
Polar H8 E 341 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 341 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 341 8x48 G.H5 G 352 G.H5.24
Aromatic ICL3 R 263 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 263 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 172 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 172 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 165 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 165 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 281 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 281 6x36 G.H5 L 353 G.H5.25
Polar ICL3 S 268 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 V 262 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 265 - G.H5 L 348 G.H5.20
Hydrophobic TM5 L 259 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 172 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 E 270 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 270 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 M 255 5x61 G.H5 L 353 G.H5.25