GPR183 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7TUZ

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.STR.2022.04.006

PUBLICATION DATE

April 13, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

(2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol - Agonist pubchem

ENDOGENOUS LIGANDS

7α,25-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β, 27-dihydroxycholesterol, 7β, 25-dihydroxycholesterol, 7α-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 7β-hydroxycholesterol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 232 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 232 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 L 232 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 232 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 L 137 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM7 A 311 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 A 311 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 238 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 238 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 141 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 141 34x55 G.HN E 28 G.HN.52
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 133 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 133 3x54 G.H5 C 351 G.H5.23
Polar TM2 N 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 N 230 5x72 G.H5 T 340 G.H5.12
Polar C-term K 313 - G.H5 F 354 G.H5.26
Hydrophobic C-term K 313 - G.H5 F 354 G.H5.26
Van-der-waals C-term K 313 - G.H5 F 354 G.H5.26
Polar TM6 T 245 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM4 R 144 4x38 G.HN R 24 G.HN.48
Polar TM3 A 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 129 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 129 3x50 G.H5 L 353 G.H5.25
Aromatic TM6 K 241 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 241 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 232 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 L 232 - G.H5 A 338 G.H5.10
Hydrophobic TM3 A 132 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 T 226 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 226 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 249 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL3 P 231 - G.H5 D 337 G.H5.09
Hydrophobic TM7 A 311 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 A 311 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Polar C-term C 312 - G.H5 G 352 G.H5.24
Van-der-waals C-term C 312 - G.H5 G 352 G.H5.24
Ionic TM4 R 144 4x38 G.HN E 28 G.HN.52
Polar TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 144 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 I 219 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 133 3x54 G.H5 L 348 G.H5.20
Polar ICL3 T 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 233 - G.H5 D 341 G.H5.13
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 246 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 246 6x37 G.H5 L 353 G.H5.25
Polar TM7 A 311 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 A 311 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 242 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 232 - G.S6 Y 320 G.S6.02
Polar TM5 N 230 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 N 230 5x72 G.H5 D 337 G.H5.09
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 C 351 G.H5.23