GPR139 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VUJ

RESOLUTION

3.8 Å

REFERENCE

10.1038/S41422-021-00591-W

PUBLICATION DATE

Dec. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

JNJ-63533054 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

L-phenylalanine, L-tryptophan



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 A 143 4x40 G.HN Q 31 G.HN.48
Hydrophobic ICL3 F 216 - G.S6 Y 350 G.S6.02
Polar TM3 D 125 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 381 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 P 133 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 133 34x50 G.H5 I 373 G.H5.15
Hydrophobic ICL3 L 218 - G.h4s6 T 340 G.h4s6.03
Van-der-waals ICL3 L 218 - G.h4s6 T 340 G.h4s6.03
Hydrophobic TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM2 V 62 2x39 G.H5 E 380 G.H5.22
Van-der-waals TM2 V 62 2x39 G.H5 E 380 G.H5.22
Hydrophobic ICL3 R 219 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 R 219 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 K 135 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM3 A 129 3x53 G.H5 Y 381 G.H5.23
Polar ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Polar H8 R 291 8x49 G.H5 R 379 G.H5.21
Hydrophobic ICL2 P 133 34x50 G.H5 L 374 G.H5.16
Van-der-waals ICL2 P 133 34x50 G.H5 L 374 G.H5.16
Hydrophobic ICL2 L 134 34x51 G.H5 C 369 G.H5.11
Van-der-waals ICL2 L 134 34x51 G.H5 C 369 G.H5.11
Hydrophobic ICL2 P 133 34x50 G.H5 K 370 G.H5.12
Van-der-waals TM4 P 142 4x39 G.HN K 34 G.HN.51
Hydrophobic TM3 V 130 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 378 G.H5.20
Aromatic ICL3 F 216 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL3 F 216 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 F 216 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM3 V 130 3x54 G.H5 L 383 G.H5.25
Polar TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Polar TM3 A 129 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 377 G.H5.19
Van-der-waals ICL3 F 216 - G.S6 C 349 G.S6.01
Polar ICL3 R 219 - G.H5 V 384 G.H5.26
Hydrophobic TM6 L 230 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 230 6x37 G.H5 L 383 G.H5.25
Ionic H8 R 291 8x49 G.H5 E 380 G.H5.22
Polar H8 R 291 8x49 G.H5 E 380 G.H5.22
Van-der-waals H8 R 291 8x49 G.H5 E 380 G.H5.22
Hydrophobic ICL2 L 134 34x51 G.H5 K 370 G.H5.12
Polar H8 R 291 8x49 G.H5 Y 381 G.H5.23
Hydrophobic TM6 I 229 6x36 G.H5 N 382 G.H5.24
Polar ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Polar TM7 Y 285 7x53 G.H5 N 382 G.H5.24
Van-der-waals TM7 Y 285 7x53 G.H5 N 382 G.H5.24
Polar ICL3 L 218 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 L 218 - G.h4s6 Y 348 G.h4s6.20
Polar TM6 T 226 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM4 Y 141 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 Y 141 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 134 34x51 G.H5 I 373 G.H5.15
Hydrophobic ICL2 L 134 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 134 34x51 G.H5 F 366 G.H5.08
Hydrophobic TM6 I 229 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM3 R 126 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 383 G.H5.25
Hydrophobic TM2 V 62 2x39 G.H5 Y 381 G.H5.23
Polar H8 S 289 8x47 G.H5 N 382 G.H5.24
Hydrophobic H8 S 289 8x47 G.H5 N 382 G.H5.24
Van-der-waals H8 S 289 8x47 G.H5 N 382 G.H5.24
Ionic ICL1 K 60 - G.H5 E 380 G.H5.22
Polar ICL1 K 60 - G.H5 E 380 G.H5.22
Hydrophobic ICL1 K 60 - G.H5 E 380 G.H5.22
Van-der-waals ICL1 K 60 - G.H5 E 380 G.H5.22
Hydrophobic TM6 K 225 6x32 G.H5 V 384 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 V 384 G.H5.26