SST2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WIG

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41422-022-00669-Z

PUBLICATION DATE

June 1, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 78 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 78 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 S 250 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 148 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 148 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Polar H8 N 318 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM5 V 242 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 242 5x72 G.S6 Y 320 G.S6.02
Hydrophobic H8 S 316 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 244 - G.S6 Y 320 G.S6.02
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 152 34x55 G.hns1 R 32 G.hns1.03
Polar H8 S 316 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 S 316 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 151 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 148 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL3 K 246 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM5 V 242 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 V 235 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 234 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 253 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 258 6x37 G.H5 L 353 G.H5.25
Ionic TM5 R 241 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 241 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 241 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 M 257 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 242 5x72 G.H5 A 338 G.H5.10
Polar ICL3 S 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 254 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 235 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 235 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 S 238 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 238 5x68 G.H5 I 344 G.H5.16
Ionic ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 241 5x71 G.H5 T 340 G.H5.12
Hydrophobic TM6 V 254 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM4 R 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 V 242 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 253 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 253 6x32 G.H5 L 353 G.H5.25