GAL2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

galanin, galanin-like peptide, spexin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 R 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Polar ICL2 R 137 34x57 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 R 137 34x57 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 R 137 34x57 G.H5 Y 243 G.H5.23
Hydrophobic TM6 V 234 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM3 I 127 3x54 G.H5 L 236 G.H5.16
Hydrophobic H8 S 296 8x47 G.H5 V 246 G.H5.26
Hydrophobic H8 F 299 8x50 G.H5 N 244 G.H5.24
Van-der-waals H8 F 299 8x50 G.H5 N 244 G.H5.24
Polar TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Polar ICL2 R 134 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 131 34x51 G.S1 L 34 G.S1.02
Polar TM2 T 60 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 E 242 G.H5.22
Polar ICL2 H 132 34x52 G.s2s3 D 77 G.s2s3.01
Aromatic H8 H 298 8x49 G.H5 R 241 G.H5.21
Hydrophobic H8 H 298 8x49 G.H5 R 241 G.H5.21
Van-der-waals H8 H 298 8x49 G.H5 R 241 G.H5.21
Hydrophobic ICL2 L 131 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 228 G.H5.08
Polar TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM2 T 60 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 243 G.H5.23
Polar TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM6 K 233 6x32 G.H5 V 246 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 V 246 G.H5.26
Hydrophobic ICL2 L 131 34x51 G.H5 K 232 G.H5.12
Polar TM7 Y 292 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 127 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM4 T 138 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 138 4x38 G.hns1 R 31 G.hns1.02
Polar ICL2 E 135 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 235 G.H5.15
Hydrophobic TM3 R 123 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 131 34x51 G.S3 V 79 G.S3.01
Hydrophobic TM6 A 230 6x29 G.H5 V 246 G.H5.26
Polar TM6 V 234 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 V 234 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 V 234 6x33 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 K 232 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 232 G.H5.12
Polar H8 S 296 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 S 296 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 S 296 8x47 G.H5 N 244 G.H5.24
Hydrophobic ICL2 L 131 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 235 G.H5.15