ADGRD1 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WU2

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41586-022-04580-W

PUBLICATION DATE

April 27, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 664 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 664 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 665 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 665 - G.H5 R 380 G.H5.12
Polar TM3 H 656 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 656 3x53 G.H5 Y 391 G.H5.23
Polar TM3 I 662 3x59 G.H5 Q 384 G.H5.16
Ionic TM5 D 744 5x67 G.H5 R 385 G.H5.17
Polar TM5 D 744 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 D 744 5x67 G.H5 R 385 G.H5.17
Aromatic ICL2 F 665 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 665 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 V 664 - G.H5 H 387 G.H5.19
Hydrophobic TM6 L 757 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 665 - G.S3 F 219 G.S3.03
Hydrophobic TM3 M 660 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 660 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 S 667 - G.H5 H 387 G.H5.19
Hydrophobic TM5 I 741 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL3 I 748 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 V 661 3x58 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 661 3x58 G.H5 Y 391 G.H5.23
Polar TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 660 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 657 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM3 M 660 3x57 G.H5 Q 390 G.H5.22
Van-der-waals TM3 M 660 3x57 G.H5 Q 390 G.H5.22
Aromatic ICL2 F 665 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 665 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 665 - G.S1 H 41 G.S1.02
Hydrophobic TM6 A 761 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 761 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 661 3x58 G.H5 L 388 G.H5.20
Polar TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 V 664 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 664 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 665 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 665 - G.S3 V 217 G.S3.01
Hydrophobic TM5 I 738 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 738 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 738 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 734 5x57 G.H5 L 393 G.H5.25
Polar TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 664 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 741 5x64 G.H5 L 394 G.H5.26
Polar H8 S 811 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 811 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 811 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 665 - G.H5 I 383 G.H5.15
Polar TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 765 6x45 G.H5 L 393 G.H5.25
Hydrophobic H8 N 810 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 810 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 764 6x44 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 764 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 665 - G.H5 C 379 G.H5.11