ADGRG4 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WUJ

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-022-04590-8

PUBLICATION DATE

April 27, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 K 2990 7x61 G.H5 E 392 G.H5.24
Van-der-waals TM7 K 2990 7x61 G.H5 E 392 G.H5.24
Polar TM3 V 2839 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 2839 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 N 2843 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 N 2843 - G.S3 V 217 G.S3.01
Hydrophobic TM5 V 2923 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 2923 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 2945 6x45 G.H5 L 393 G.H5.25
Polar TM3 H 2833 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 2833 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 2833 3x53 G.H5 Y 391 G.H5.23
Polar TM3 A 2837 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 2837 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 2837 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 N 2843 - G.hns1 A 39 G.hns1.03
Polar TM3 E 2830 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 2830 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 2830 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 2841 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 2841 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 2842 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 2842 - G.S3 V 217 G.S3.01
Hydrophobic TM5 V 2916 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 2916 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 2920 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 2920 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM2 P 2776 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 P 2776 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 2842 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 2842 - G.S3 F 219 G.S3.03
Hydrophobic TM5 V 2923 5x64 G.H5 L 394 G.H5.26
Polar TM7 K 2990 7x61 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 2920 5x61 G.H5 L 388 G.H5.20
Polar ICL1 D 2774 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 D 2774 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 D 2774 - G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 2948 6x48 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 2845 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 2845 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 I 2844 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 I 2844 - G.H5 H 387 G.H5.19
Hydrophobic TM3 L 2838 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 2838 3x58 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 2842 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 2842 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 2842 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 2838 3x58 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 2838 3x58 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 2842 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 2842 - G.H5 C 379 G.H5.11
Aromatic ICL2 F 2842 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 2842 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 2842 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 2838 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 2838 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 2842 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 2842 - G.H5 F 376 G.H5.08
Hydrophobic TM6 G 2941 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 2941 6x41 G.H5 L 393 G.H5.25
Polar ICL2 Y 2845 - G.HN K 34 G.HN.51
Hydrophobic ICL2 Y 2845 - G.HN K 34 G.HN.51
Van-der-waals ICL2 Y 2845 - G.HN K 34 G.HN.51
Polar ICL2 N 2843 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 V 2841 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 2841 - G.H5 I 383 G.H5.15
Hydrophobic TM5 V 2923 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 2923 5x64 G.H5 R 385 G.H5.17
Polar TM5 Q 2919 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 2919 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 2919 5x60 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 2847 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 P 2847 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 Y 2845 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 2845 - G.HN Q 35 G.HN.52
Hydrophobic TM3 L 2838 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 2838 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 2920 5x61 G.H5 L 393 G.H5.25
Polar TM7 H 2986 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM7 H 2986 7x57 G.H5 Y 391 G.H5.23
Van-der-waals TM7 H 2986 7x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 2841 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 2841 - G.H5 Q 384 G.H5.16
Polar TM6 H 2937 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 H 2937 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 H 2937 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 M 2834 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 2834 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 2842 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 2842 - G.H5 I 383 G.H5.15
Hydrophobic TM2 P 2776 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 2776 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM7 K 2990 7x61 G.H5 Y 391 G.H5.23