GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XZ6

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41594-022-00816-5

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

65 interactions (Click to see)

LIGANDS

APD668 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

N-palmitoylethanolamine, anandamide, N-oleoylethanolamide, SEA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Aromatic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM3 A 106 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 106 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 199 5x73 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 202 5x76 G.H4 R 342 G.H4.12
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 192 5x66 G.H5 L 393 G.H5.25
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Van-der-waals ICL2 K 115 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Ionic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 222 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL4 W 282 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 W 282 - G.H5 E 392 G.H5.24
Polar TM4 S 118 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 118 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 G 206 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM5 G 210 5x84 G.H4 R 347 G.H4.17
Van-der-waals TM5 G 210 5x84 G.H4 R 347 G.H4.17
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 113 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 205 5x79 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 205 5x79 G.H4 D 343 G.H4.13
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 209 5x83 G.hgh4 Y 318 G.hgh4.08
Van-der-waals TM5 A 209 5x83 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 I 191 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 209 5x83 G.H4 D 343 G.H4.13
Ionic ICL1 D 37 - G.hns1 R 38 G.hns1.02
Polar ICL1 D 37 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 D 37 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 191 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 192 5x66 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 205 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 A 205 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM5 S 196 5x70 G.H5 L 394 G.H5.26
Van-der-waals TM5 S 196 5x70 G.H5 L 394 G.H5.26
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals TM5 A 205 5x79 G.H4 R 342 G.H4.12
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 T 226 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 226 6x36 G.H5 L 393 G.H5.25
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Polar ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic ICL1 D 37 - G.HN K 34 G.HN.51
Van-der-waals ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 M 202 5x76 G.H4 L 346 G.H4.16
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 114 34x54 G.H5 I 383 G.H5.15
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Polar TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 209 5x83 G.H4 R 347 G.H4.17
Van-der-waals TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 195 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM5 G 206 5x80 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 G 206 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Polar TM6 K 222 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 222 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 Y 391 G.H5.23
Van-der-waals TM5 A 192 5x66 G.H5 L 394 G.H5.26